Recovery and inactivation of infectious retroviruses from factor VIII concentration. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Recovery and inactivation of infectious retroviruses from factor VIII concentration.

Lancet. 1984 Sep 29;2(8405):722-3. Unique Identifier : AIDSLINE MED/85011552
Levy JA; Mitra G; Mozen MM

Abstract: The ability of infectious retroviruses to withstand the procedures used for factor VIII concentration was investigated. Mouse retroviruses added to human plasma survived these procedures and remained infectious in lyophilised samples of factor VIII. Lyophilised material had to be heated at 68 degrees C for several hours before substantial quantities of infectious virus became inactivated. These findings support the possible role of retroviruses in AIDS, and indicate that factor VIII concentrates must be heated to inactivate these infectious viruses.
Keywords: Animal Drug Contamination *Factor VIII Heat Hemophilia/DRUG THERAPY Human Mice Retroviridae/*ISOLATION & PURIF Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDanimaldrugcontaminationKWDfactorviiiheathemophilia/drugtherapyhumanmiceretroviridae/KWDisolation&purifsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
850130
M8510006

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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