Oral hairy leucoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Oral hairy leucoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus.

Lancet. 1984 Oct 13;2(8407):831-4. Unique Identifier : AIDSLINE MED/85011653
Greenspan D; Greenspan JS; Conant M; Petersen V; Silverman S Jr; de Souza Y

Abstract: An outbreak of a new form of oral leucoplakia, found principally on the lateral borders of the tongue, is reported in male homosexuals in the San Francisco area. Many of the patients showed evidence of immunosuppression, and candida was often found in the lesions. The characteristic histology is similar to that of the flat wart of skin. There was immunocytochemical evidence of papillomavirus core antigen in 77% of 30 biopsy specimens, but no papillomaviruses were detected by electron microscopy in samples from 6 randomly selected patients. In 5 of these 6 patients there was evidence of a herpes-type virus. Pneumocystis carinii pneumonia has developed in 8 of 37 patients in a 33-month period. This leucoplakia may presage AIDS, may be associated with both papillomavirus and a herpes-type virus, and may offer clues to the pathogenesis of other forms of oral epithelial hyperplasia and dysplasia.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS Adult Antigens, Viral/ANALYSIS California Candida/ISOLATION & PURIF Disease Outbreaks/*EPIDEMIOLOGY Herpesviridae/*ISOLATION & PURIF *Homosexuality Human Hypersensitivity, Delayed Leukoplakia, Oral/COMPLICATIONS/EPIDEMIOLOGY/IMMUNOLOGY/ *MICROBIOLOGY/PATHOLOGY Male Middle Age Papillomavirus/*IMMUNOLOGY Skin Tests Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Tongue/MICROBIOLOGY/PATHOLOGY Tongue Neoplasms/COMPLICATIONS/EPIDEMIOLOGY/IMMUNOLOGY/ *MICROBIOLOGY/PATHOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complicationsadultantigens,viral/analysiscaliforniacandida/isolation&purifdiseaseoutbreaks/KWDepidemiologyherpesviridae/KWDisolation&purifKWDhomosexualityhumanhypersensitivity,delayedleukoplakia,oral/complications/epidemiology/immunology/KWDmicrobiology/pathologymalemiddleagepapillomavirus/KWDimmunologyskintestssupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDtongue/microbiology/pathologytongueneoplasms/complications/epidemiology/immunology/KWDmicrobiology/pathologyjournalarticle
850130
M8510004

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