Boston : Nijhoff ; Hingham, MA : Distributors for North America, Kluwer Academic, c1985 xx, 409 p. : ill (Developments in oncology ; DION 28) Unique Identifier : AIDSLINE CAT/8412702
Cancer. 1984 Oct 15;54(8):1582-5. Unique Identifier : AIDSLINE MED/85001751
Varsano S; Manor Y; Steiner Z; Griffel B; Klajman A
Kaposi s sarcoma (KS) and angioimmunoblastic lymphadenopathy (AILD) are exceptionally rare neoplastic diseases, although the former has recently been more frequently reported among certain populations, and is lately a topic for extensive medical and investigational interest. This case is unique in that it describes an
Cell Immunol. 1984 Oct 1;88(1):222-7. Unique Identifier : AIDSLINE MED/85002053
Kim BS
Intravenous transfer of BALB/c spleen cells (1-10 X 10(6] immunized against semi-allogeneic hybrid cells bearing H-2k antigens into BALB/c mice resulted in splenomegaly (2- to 6-fold). As few as 2 X 10(4) spleen cells could transfer splenomegaly. A significant spleen enlargement was seen from 2 weeks after cell transf
Kaposi s sarcoma frequently develops in patients with the acquired immunodeficiency syndrome (AIDS), and in most cases cutaneous lesions herald the disease. Although the lungs are often involved when the neoplasm becomes disseminated, it is rare for the initial diagnosis to be made by lung biopsy. This report describe
Clinically uninvolved skin in a homosexual patient with acquired immunodeficiency syndrome and Kaposi s sarcoma showed abnormal vascular proliferation (pre-Kaposi s sarcoma). The diagnostic and therapeutic implications of this finding are discussed.
Radiographs and clinical records of 100 patients with tuberculosis or mycobacteriosis and six patients infected with Bacillus Calmette-Guerin (BCG) or methanol extraction residue of BCG (MER) were reviewed. Radiographic presentations were categorized. Tuberculosis or mycobacteriosis simulated pulmonary neoplasm in 64
The interferon system has been implicated in the diagnosis and potential treatment of acquired immune deficiency syndrome (AIDS). In our study of AIDS patients we have identified the presence of circulating serum interferon inactivator(s). These interferon inactivators were not detected in AIDS prodrome patients or in
Soc Work Health Care. 1984 Summer;9(4):45-62. Unique Identifier : AIDSLINE MED/85017066
Furstenberg AL; Olson MM
AIDS (Acquired Immune Deficiency Syndrome) is a new contagious disease for which no cause or cure is known at present. The majority of people who have contracted AIDS is gay men. This paper examines individual and societal responses to this illness and to homosexuality that create issues for social work practice. Thes
Because of reports that acquired immune deficiency syndrome (AIDS) might be transmissible by blood transfusion, we studied potential surrogate tests that could be used for screening donors. Male donors at one volunteer blood center and two plasma centers were screened for total lymphocyte count, OKT3, OKT4, OKT8, OKT1
Am J Med. 1984 Oct;77(4):760-4. Unique Identifier : AIDSLINE MED/85020139
Milligan SA; Katz MS; Craven PC; Strandberg DA; Russell IJ; Becker RA
A 57-year-old man with a prior episode of lymphatic toxoplasmosis presented with signs of anterior panhypopituitarism, which was confirmed by standard endocrinologic evaluation. The diagnosis of central nervous system toxoplasmosis was established by brain biopsy after nondiagnostic serologic and radiographic studies.
Juxta-centromeric fragility of chromosomes 1, 2, 9, 16, has been described at least thrice in unrelated patients in association with combined immunodeficiency. This association has been confirmed by our findings in both immunodeficient and cancer patients. In our opinion, both the fragility and the immunodeficiency ar
A 22-year-old homosexual man had persistent systemic lymphadenopathy and a three-week history of rapid swelling and induration of his right upper eyelid. Acquired immune deficiency leading to the development of lymphoma was suspected. A biopsy specimen of the mass revealed Burkitt s lymphoma and treatment with systemi
Moskowitz LB; Hensley GT; Chan JC; Gregorios J; Conley FK
We reviewed the neuropathologic characteristics of 52 cases of acquired immune deficiency syndrome (AIDS) at autopsy. Histologically significant neuropathologic lesions were found in 38 cases. We believed that infection was the predominant pathologic process in 26 cases; occasionally, multiple infectious agents were p
Arch Sex Behav. 1984 Aug;13(4):291-300. Unique Identifier : AIDSLINE MED/85021941
Ebbesen P; Melbye M; Biggar RJ
Interviewed to obtain the first quantitative data from Scandinavia on lifestyle factors of possible importance for their health were 259 Danish male homosexuals. The frequency of various sex acts, frequency of change in partner, visits to the United States , sexual contacts with victims
Green TL; Beckstead JH; Lozada-Nur F; Silverman S Jr; Hansen LS
There has been a striking increase in the incidence of oral Kaposi s sarcoma in association with acquired immunodeficiency syndrome (AIDS). Oral lesions are seen in approximately 50% of AIDS patients with Kaposi s sarcoma. Lesions may appear as a flat or raised pigmented area, often resembling a benign vascular lesion
Natural Killer (NK) cell activity of peripheral blood mononuclear cells (PBMC) against K562 myeloid cells was studied in six normal heterosexual men and six patients with acquired immune deficiency syndrome (AIDS). The mean NK cell activity in six patients with AIDS was 28.74 +/- 6.82% (SEM) compared with 47.24 +/- 7.
The courses of 19 patients with Pneumocystis carinii pneumonia complicating the acquired immune deficiency syndrome (AIDS) were reviewed. Compared with previous reviews of Pneumocystis pneumonia in patients without AIDS, Pneumocystis pneumonia in patients with AIDS often has a more prolonged clinical prodrome, with pu
Ann Intern Med. 1984 Nov;101(5):617-23. Unique Identifier : AIDSLINE MED/85020948
Chamberland ME; Castro KG; Haverkos HW; Miller BI; Thomas PA; Reiss R; Walker J; Spira TJ; Jaffe HW; Curran JW
From 1 June 1981 through 31 January 1984, 201 cases of the acquired immunodeficiency syndrome were reported involving persons who could not be classified into a group identified to be at increased risk for this syndrome. Thirty-five had received transfusions of single-donor blood components in the 5 years preceding di
Ann Intern Med. 1984 Nov;101(5):641-5. Unique Identifier : AIDSLINE MED/85020955
Pitchenik AE; Cole C; Russell BW; Fischl MA; Spira TJ; Snider DE Jr
To study the association between mycobacterial disease and the acquired immunodeficiency syndrome, we reviewed the records of all cases of tuberculosis and all cases of the syndrome reported in Dade County, Florida, from January 1980 through June 1983. Tuberculosis was diagnosed in 27 of 45 Haitians with the syndrome,
Ten patients with clinical and laboratory features of acquired immune deficiency syndrome (AIDS) underwent renal ultrasonography prior to biopsy because of proteinuria, azotemia, or uremia. Four patients had a history of intravenous heroin abuse and were considered separately so as to exclude it as a cause of nephropa
We have examined the primary immune response, the numbers of the total T (T-11+) cells, T-helper (T4+) cells, T-suppressor (T8+) cells, NK cells (Leu7+) and the level of serum IgG in 83 healthy male heterosexuals and compared the data to those obtained from 12 clinically diagnosed AIDS patients and 92 asymptomatic mal
Gluckman JC; Cavaille-Coll M; Klatzmann D; Messiah A; Rozenbaum W; Lachiver D; Kernbaum S; Debre P; Brisson E; Chapuis F
In order to assess the actual value of the in vitro tests of cellular immunity performed to provide diagnostic evidence for acquired immune deficiency syndrome (AIDS) or related syndromes, we have evaluated T-lymphocyte subsets and in vitro proliferative responses. The respective profiles of 44 symptom-free homosexual
Kaltoft K; Thestrup-Pedersen K; Jensen JR; Bisballe S; Zachariae H
Eighteen patients with mycosis fungoides were studied in order to establish cell lines that might be associated with the human T cell leukaemia-lymphoma virus (HTLV). Three T cell lines were established, two from affected skin and one from a lymph node showing dermatopathic lymphadenopathy. The T cells expressed OKT3
Can Med Assoc J. 1984 Sep 15;131(6):595-600. Unique Identifier : AIDSLINE MED/85001668
Amato D; Fernandes BJ; Klein M
A black, West Indian woman with adult T-cell leukemia-lymphoma (ATLL), hypercalcemia, peripheral and retroperitoneal lymphadenopathy, and serum antibodies to human T-lymphotropic virus (HTLV) was found to have massive mediastinal adenopathy, a feature not previously reported in patients with ATLL. In addition, she had
Cancer Lett. 1984 Sep;24(2):129-39. Unique Identifier : AIDSLINE MED/85001842
Nakao Y; Matsuda S; Matsui T; Nakagawa T; Fujita T; Uchiyama T; Maeda S; Okamoto Y; Masaoka T; Ito Y
We assayed the capacity of tumor promoters to induce human T-cell leukemia/lymphoma virus (HTLV) structural proteins p19 and p24 from the HTLV genome-carrying adult T-cell leukemia (ATL) cell lines, MT-1 and KH-2Lo, and fresh ATL cells. Among the tested substances, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 12-hexad
Screening of sixty-six asymptomatic homosexual men from Copenhagen revealed significantly lower Leu-3a/Leu-2a ratios as compared to controls. Ten (15%) of the homosexuals had a ratio less than or equal to 1.0. The low Leu-3a/Leu-2a ratios were the result of an increase in the absolute number of Leu-2a cells. Homosexua
Gardner M; Marx P; Maul D; Osborn K; Henrickson R; Lerche N; Munn B; Bencken B; Bryant M
This paper reviews the major features of a simian model of acquired immunodeficiency ( SAIDS ), SAIDS occurs endemically in colonies of macaque monkeys in the United States and resembles AIDS in humans in overall clinical manifestations, pathology, and immune deficiency. An infectious
In order to study the genetical susceptibility to infection by adult T-cell leukemia virus (ATLV), which is considered to be a main causative agent of adult T-cell leukemia (ATL), the HLA profile of persons with antibody against ATLV-associated antigen (anti-ATLA) was compared with that of antibody-negative persons in
Shikano T; Ueno N; Matsumoto T; Ohkawa M; Tono-Oka T; Okano M; Yano S; Osato T
A 6-year-old girl was admitted for cervical lymphadenopathy. She was diagnosed histologically as having Burkitt s lymphoma with partial involvement of follicles. Immunological study of a biopsy specimen demonstrated that many cells were surface immunoglobulin (lambda light chain)-positive, and chromosomal analysis rev
Chromosome abnormalities were studied in primary cultures and in established T-cell lines from patients with human T-cell leukemia virus (HTLV)-positive leukemia or lymphoma. The present findings, and data from other laboratories, indicated that primary cultures of the HTLV-positive neoplastic cells nearly always show
Nature. 1984 Oct 18-24;311(5987):626-31. Unique Identifier : AIDSLINE GENBANK/X01402
Leonard WJ; Depper JM; Crabtree GR; Rudikoff S; Pumphrey J; Robb RJ; Kronke M; Svetlik PB; Peffer NJ; Waldmann TA; et al
We have purified the human T-cell growth factor (interleukin-2) receptor and have cloned, sequenced and expressed cDNAs corresponding to this receptor. We identify one gene, but two interleukin-2 receptor mRNAs which differ in their polyadenylation signals. We have isolated an additional cDNA that may correspond to an
Proc Natl Acad Sci U S A. 1984 Oct;81(19):6202-6. Unique Identifier : AIDSLINE MED/85014934
Kiyokawa T; Yoshikura H; Hattori S; Seiki M; Yoshida M
The DNA fragments of the 5 and 3 halves of the putative env gene predicted from the DNA sequence of human T-cell leukemia virus (HTLV) provirus were inserted into expression vectors pORF2 and pORF1, respectively, and two hybrid proteins composed of env polypeptides and beta-galactosidase were efficiently produced in
Proc Natl Acad Sci U S A. 1984 Oct;81(19):6207-11. Unique Identifier : AIDSLINE MED/85014935
Franchini G; Wong-Staal F; Gallo RC
We examined the DNA and RNA of fresh leukemic cells (five patients) and long-term cultured T lymphocytes (four patients) from patients with adult T-cell leukemia for the presence of human T-cell leukemia virus (HTLV-I) sequences. In all cases HTLV-I provirus was found and several species of viral mRNAs were observed i
Science. 1984 Oct 12;226(4671):172-4. Unique Identifier : AIDSLINE MED/85016654
Mitsuya H; Popovic M; Yarchoan R; Matsushita S; Gallo RC; Broder S
A recently discovered member of the human T-cell leukemia virus (HTLV) family of retroviruses has been etiologically linked to the acquired immune deficiency syndrome (AIDS). This virus, which has been designated HTLV-III, is tropic for OKT4-bearing (helper-inducer) T cells. Moreover, the virus is cytopathic for these
Science. 1984 Oct 12;226(4671):177-9. Unique Identifier : AIDSLINE MED/85016656
Wachsman W; Shimotohno K; Clark SC; Golde DW; Chen IS
Human T-cell leukemia viruses (HTLV) are closely associated with some human T-cell leukemias and lymphomas. A unique 3 region of the HTLV genome is believed to be involved in HTLV-induced cellular transformation, although the function of this region has yet to be determined. A subgenomic messenger RNA transcribed fro
Am J Med Sci. 1984 Oct;288(3):109-13. Unique Identifier : AIDSLINE MED/85020173
Sherertz RJ; Peacock JE Jr; Sixbey JW; Folds JD; Bowdre JH; Huang ES; Hamilton JD; McDowell DL
Twenty asymptomatic male homosexuals living in North Carolina were evaluated looking at epidemiologic, immunologic and virologic characteristics. In ten subjects selected for inhalant nitrite use a significantly higher frequency of multiple drug abuse and a trend toward greater sexual promiscuity was found in comparis
The effectiveness of fiberoptic bronchoscopy with the addition of bronchoalveolar lavage (BAL) was evaluated in 72 patients with the acquired immune deficiency syndrome (AIDS) and parenchymal pulmonary disease. The diagnostic yield varied for different pathogens and was 94% (45/48 cases) for Pneumocystis carinii, 67%
We observed three cases of cytomegalovirus ( CMV ) infection of the nervous system in association with acquired immune deficiency syndrome. The first patient had demyelinating lesions in the spinal cord with relative preservati
Pneumocystis carinii organisms can be identified in routine cytologic smears stained by the Papanicolaou method and viewed under ultraviolet light in a fluorescence microscope. The organisms can be identified easily in thin, well-preserved cytologic smears. No false-positive results were obtained when 55 Papanicolaou
Goedert JJ; Sarngadharan MG; Biggar RJ; Weiss SH; Winn DM; Grossman RJ; Greene MH; Bodner AJ; Mann DL; Strong DM; et al
A cohort of homosexual men at high risk of the acquired immunodeficiency syndrome (AIDS) was monitored to examine the relation between lifestyle, clinical conditions, T-lymphocyte subsets, and antibody to the AIDS-associated human retrovirus, human T-cell leukaemia virus III (HTLV-III). HTLV-III antibodies were presen
The ability of infectious retroviruses to withstand the procedures used for factor VIII concentration was investigated. Mouse retroviruses added to human plasma survived these procedures and remained infectious in lyophilised samples of factor VIII. Lyophilised material had to be heated at 68 degrees C for several hou
Lancet. 1984 Oct 13;2(8407):831-4. Unique Identifier : AIDSLINE MED/85011653
Greenspan D; Greenspan JS; Conant M; Petersen V; Silverman S Jr; de Souza Y
An outbreak of a new form of oral leucoplakia, found principally on the lateral borders of the tongue, is reported in male homosexuals in the San Francisco area. Many of the patients showed evidence of immunosuppression, and candida was often found in the lesions. The characteristic histology is similar to that of the
Reverse transcriptase activity of lymphadenopathy associated virus was assayed after exposure to various standard chemical disinfectants. 25% ethanol or 1% glutaraldehyde should prove sufficient to disinfect medical instruments, and 0.2% sodium hypochlorite for cleaning floors and benches. 0.1% formalin is too slow to
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