Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
LYMPHOMAS IN PERSONS WITH NATURALLY OCCURRING IMMUNODEFICIENCY DISORDERS
Prog Cancer Res Ther; 27:225-34 1984. Unique Identifier : AIDSLINE ICDB/85603736 Filipovich AH; Zerbe D; Spector BD; Kersey JH; Immunodeficiency Cancer Registry, University of Minnesota; Hospitals, Minneapolis, MN 55455
Abstract:
This chapter presents descriptive data regarding host and tumor characteristics for cases of lymphomas occurring in immunodeficient patients reported to the Immunodeficiency Cancer Registry (ICR) and to the Denver Tumor Transplant Registry (DTTR). The study covers 385 cases of cancer in naturally immunodeficient patients from the ICR and 1,275 patients from the DTTR, 98% of whom were renal transplants who received immunosuppressive therapy. The natural immunodeficiencies include ataxia telangiectasia (AT) (133 cases of cancer), Wiscott-Aldrich syndrome (WAS) (59 cases), common variable immunodeficiency disease (CVID) (88 cases), severe combined immunodeficiency disease (SCID) (24 cases) and others, covering 81 cancer cases. Non-Hodgkin's lymphoma (NHL) comprised the majority of cancers in patients with AT (42%), WAS (70%) and SCID (50%). In patients with CVID, carcinomas were the most common cancer (44%) with NHL comprising 42%. Other cancers that were fairly common with these conditions were leukemias and Hodgkin's disease. Some mention is made of more rare types of immunodeficiencies and cancers. Of the 1,354 tumors in the DTTR, 252 were solid lymphomas, 131 of which were histiocytic lymphomas. All of the immunodeficient patients shared a number of characteristics. (1) Histiocytic or large cell NHL predominates. (2) The central nervous system is a major primary site. (3) Lymphomas occur in younger patients than nonlymphoid tumors and have a shorter latency period after the onset of immunosuppression. (4) Transitional or hyperplastic premalignant lesions and polyclonal tumors that are clinically aggressive are observed. (5) A frequent association with Epstein-Barr virus and possibly other viruses is seen in lymphoproliferative disorders associated with immunodeficiencies. (25 Refs)
Keywords: Adolescence Adult Age Factors Aged Ataxia Telangiectasia/COMPLICATIONS Child Child, Preschool Comparative Study Female Hodgkin's Disease/COMPLICATIONS Human Immunologic Deficiency Syndromes/*COMPLICATIONS/EPIDEMIOLOGY Infant Kidney/TRANSPLANTATION Kidney Transplantation Leukemia, Lymphocytic/COMPLICATIONS Lymphoma/*COMPLICATIONS/EPIDEMIOLOGY Male Middle Age Minnesota Retrospective Studies Sex Factors United States Wiskott-Aldrich Syndrome/COMPLICATIONS MEETING PAPER
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Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
