Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
IMMUNOREGULATORY DEFECTS AND EPSTEIN-BARR VIRUS-ASSOCIATED LYMPHOID DISORDERS
Prog Cancer Res Ther; 27:235-57 1984. Unique Identifier : AIDSLINE ICDB/85603737 Purtilo D; Harada S; Bechtold T; Yetz J; Rogers G; Seshi B; Department of Pathology, University of Nebraska Medical Center,; Omaha, NB 68105
Abstract:
Inherited and acquired immunodeficiencies are postulated to be involved in a number of diseases produced by Epstein-Barr Virus (EBV), especially B-cell malignant lymphomas. The X-linked lymphoproliferative syndrome (XLP) predisposes patients to EBV infections, possibly by suppressing or destroying certain T-cell populations necessary for defense against EBV. These may be both natural killer T-cells and antibody memory T-cells. Males with XLP are especially vulnerable to EBV. Other primary immunodeficiency disorders that seem to predispose to EBV infection are severe combined immune deficiency, Wiskott-Aldrich syndrome, and ataxia telangiectasia. Familial Hodgkin's disease, Chediak-Higashi disease, Bloom's syndrome, rheumatoid arthritis, Sjogren's syndrome and autoimmune disturbances are discussed as possibly having immunoregulatory defects to EBV. Some rare disorders involving immunodeficiency cluster where Burkitt's lymphoma is prevalent in Africa. Allograft patients are also at increased risk for developing lymphoproliferative neoplasias which frequently carry EBV. Acquired immunodeficiency to EBV and malignant B-cell lymphomas can emerge in patients in remission from Hodgkin's disease and leukemia. Age, sex, immunocompetence and socioeconomic status are other factors discussed with respect to the outcome of EBV infections and possible malignant lymphomas. (95 Refs)
Keywords: Acquired Immunodeficiency Syndrome/ETIOLOGY Adolescence Adult Aged Animal B-Lymphocytes Burkitt's Lymphoma/ETIOLOGY Child Child, Preschool Comparative Study Female Herpesviridae Infections/*ETIOLOGY/GENETICS Herpesvirus 4, Human Human Immunologic Deficiency Syndromes/*ETIOLOGY Infant Leukemia/*ETIOLOGY/GENETICS Lymphoma/*ETIOLOGY/GENETICS Lymphoproliferative Disorders/*ETIOLOGY/GENETICS Male Middle Age Pregnancy Socioeconomic Factors T-Lymphocytes Transplantation, Homologous MEETING PAPER REVIEW
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Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
