Bone marrow biopsies in patients with the acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Bone marrow biopsies in patients with the acquired immunodeficiency syndrome.

Hum Pathol. 1984 Nov;15(11):1048-53. Unique Identifier : AIDSLINE MED/85028991
Osborne BM; Guarda LA; Butler JJ

Abstract: Bone marrow biopsy findings in 32 homosexual patients with the acquired immunodeficiency syndrome (AIDS) or prodromal AIDS are described. A high incidence (38 per cent) of nonparatrabecular lymphohistiocytic infiltrations containing irregular small lymphocytes was observed, as well as the presence of diffuse bone marrow damage with plasmacytosis (22 per cent), decreased or absent stainable iron (50 per cent), and histologically identifiable pathogenic organisms (6 per cent). Morphologically, the lymphohistiocytic infiltrations are indistinguishable from bone marrow involvement by peripheral T-cell lymphoma, which may cause confusion, especially when a concurrent lymph node biopsy is difficult to interpret. On deeper sectioning, a specimen from one patient assumed a more granulomatous appearance. Specimens from two patients with small, poorly formed noncaseating granulomas contained demonstrable organisms.
Keywords: Acquired Immunodeficiency Syndrome/*PATHOLOGY Adult Antibodies, Viral/ANALYSIS Biopsy Bone Marrow/CYTOLOGY/IMMUNOLOGY/*PATHOLOGY Histiocytes/PATHOLOGY Human Lymph Nodes/PATHOLOGY Lymphocytes/PATHOLOGY Middle Age Plasma Cells/PATHOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDpathologyadultantibodies,viral/analysisbiopsybonemarrow/cytology/immunology/KWDpathologyhistiocytes/pathologyhumanlymphnodes/pathologylymphocytes/pathologymiddleageplasmacells/pathologyjournalarticle
850228
M8520119

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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