HLA-A,B,C and DR antigen frequencies in acquired immunodeficiency syndrome (AIDS) patients with opportunistic infections. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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HLA-A,B,C and DR antigen frequencies in acquired immunodeficiency syndrome (AIDS) patients with opportunistic infections.

Hum Immunol. 1984 Oct;11(2):99-103. Unique Identifier : AIDSLINE MED/85029910
Pollack MS; Gold J; Metroka CE; Safai B; Dupont B

Abstract: During the past three years, an epidemic of acquired immunodeficiency syndromes (AIDS) involving the presence of specific forms of cancer (notably Kaposi's sarcoma) and infection (e.g., pneumocystis carinii) ordinarily seen only in severely immunosuppressed hosts has occurred among active homosexuals, Haitian immigrants, drug users, and hemophiliacs in large cities in the United States and elsewhere. An as yet unidentified viral agent is presumably the cause of the initial immunodeficiency and host genetic factors may influence the subsequent development of different clinical symptoms in different patients. We have previously reported that the HLA antigens DR5 and DR2 are associated with susceptibility to Kaposi's sarcoma (KS) in different Caucasian subpopulations. We now have also noted that AIDS patients with opportunistic infections have a normal frequency of DR2 and DR5 and a significantly increased frequency of DR3 and that the ultimate clinical expression of AIDS in patients with unexplained lymphadenopathy may depend upon genetic factors associated with these particular DR types.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/GENETICS/ *IMMUNOLOGY Comparative Study Female Gene Frequency Histocompatibility Antigens Class II/*GENETICS Human HLA Antigens/*GENETICS Infection/COMPLICATIONS Male Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complications/genetics/KWDimmunologycomparativestudyfemalegenefrequencyhistocompatibilityantigensclassii/KWDgeneticshumanhlaantigens/KWDgeneticsinfection/complicationsmalesupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
850228
M8520089

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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