Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS.

Science. 1984 Oct 26;226(4673):453-6. Unique Identifier : AIDSLINE MED/85040343
Brun-Vezinet F; Rouzioux C; Montagnier L; Chamaret S; Gruest J; Barre-Sinoussi F; Geroldi D; Chermann JC; McCormick J; Mitchell S; et al

Abstract: The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Antibodies, Viral/*ANALYSIS Enzyme-Linked Immunosorbent Assay Female Human Lymphatic Diseases/*MICROBIOLOGY Male Radioimmunoassay Retroviridae/*IMMUNOLOGY T-Lymphocytes, Helper-Inducer/CYTOLOGY T-Lymphocytes, Suppressor-Effector/CYTOLOGY Zaire JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyantibodies,viral/KWDanalysisenzyme-linkedimmunosorbentassayfemalehumanlymphaticdiseases/KWDmicrobiologymaleradioimmunoassayretroviridae/KWDimmunologyt-lymphocytes,helper-inducer/cytologyt-lymphocytes,suppressor-effector/cytologyzairejournalarticle
850228
M8520062

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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