Natural antibodies to human T-cell leukemia/lymphoma virus in healthy Venezuelan populations. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Natural antibodies to human T-cell leukemia/lymphoma virus in healthy Venezuelan populations.

Int J Cancer. 1984 Oct 15;34(4):501-6. Unique Identifier : AIDSLINE MED/85029460
Merino F; Robert-Guroff M; Clark J; Biondo-Bracho M; Blattner WA; Gallo RC

Abstract: Serum samples of 769 healthy Venezuelan donors were assayed for natural antibodies to HTLV-I by the ELISA technique. Specific HTLV-I antibody prevalence was 6.8% but varied from 1% in Caracas to 13.7% in the Amazonas region and the State of Zulia. Adults infected with Trypanosoma cruzi had the highest HTLV-I antibody prevalence of 15%. Areas of high antibody prevalence were correlated most strongly with the presence of arthropod-borne diseases and to a lesser extent with socio-economic factors. Genetic factors were not correlated with antibody prevalence. Antibodies were seen in children as young as 3 years of age in the most endemic areas. Antibody titers increased with age, suggesting continuous exposure to the virus. The data provide clues for elucidation of the geographic variation in HTLV-I antibody prevalence seen Venezuela and other HTLV-I endemic areas. In addition, they further confirm the Caribbean region as being endemic for HTLV-I and extend this region to inland areas of South America.
Keywords: Adolescence Adult Age Factors Antibodies, Viral/*ANALYSIS Child Enzyme-Linked Immunosorbent Assay Female Human HTLV-BLV Viruses/*IMMUNOLOGY Indians, South American Male Rural Population Socioeconomic Factors Urban Population Venezuela JOURNAL ARTICLE

KWDadolescenceadultagefactorsantibodies,viral/KWDanalysischildenzyme-linkedimmunosorbentassayfemalehumanhtlv-blvviruses/KWDimmunologyindians,southamericanmaleruralpopulationsocioeconomicfactorsurbanpopulationvenezuelajournalarticle
850228
M8520050

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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