Breakdown of P.G.E. 1 synthesis is responsible for the acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Breakdown of P.G.E. 1 synthesis is responsible for the acquired immunodeficiency syndrome.

Med Hypotheses. 1984 Sep;15(1):39-46. Unique Identifier : AIDSLINE MED/85035950
Marcus SG

Abstract: This hypothesis suggests that repeated viral infections disrupt the biosynthesis of P.G.E. 1 and nullify a major system by which t lymphocytes are regulated. It is hypothesized that a breakdown of P.G.E. 1 synthesis is responsible for the acquired immunodeficiency syndrome and the frequently associated Kaposi's sarcoma. A means of restoring P.G.E. 1 synthesis and reversing the immunodeficiency is proposed.
Keywords: Acquired Immunodeficiency Syndrome/*ETIOLOGY/PREVENTION & CONTROL Adenyl Cyclase/METABOLISM Comparative Study Cyclic AMP/METABOLISM Human *Models, Biological Prostaglandins E/*BIOSYNTHESIS Sarcoma, Kaposi's/PREVENTION & CONTROL T-Lymphocytes/IMMUNOLOGY Virus Diseases/COMPLICATIONS/IMMUNOLOGY/METABOLISM JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDetiology/prevention&controladenylcyclase/metabolismcomparativestudycyclicamp/metabolismhumanKWDmodels,biologicalprostaglandinse/KWDbiosynthesissarcoma,kaposi's/prevention&controlt-lymphocytes/immunologyvirusdiseases/complications/immunology/metabolismjournalarticle
850228
M8520040

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