Characterization of the acquired immune deficiency syndrome at the cellular and molecular level. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Characterization of the acquired immune deficiency syndrome at the cellular and molecular level.

Mol Cell Biochem. 1984 Aug;63(1):3-11. Unique Identifier : AIDSLINE MED/85036250
Barrett DJ

Abstract: The acquired immunodeficiency syndrome (AIDS) is a new disease characterized by severe dysfunction of both the T cell and B cell systems, occurring in previously healthy individuals. Affected individuals may have recurrent and chronic opportunistic infections and/or Kaposi's sarcoma or other malignancy. Analysis of the cellular and subcellular components of immunity demonstrates a profound depression in the number and function of helper/inducer T cells bearing the OKT4 (Leu 3) differentiation antigen and a concomitant defect in the synthesis of the immuno-enhancing soluble growth factor, interleukin 2 (IL-2). Hypotheses to explain the etiology of the immunological dysfunction and implications for future therapy of AIDS are discussed.
Keywords: Acquired Immunodeficiency Syndrome/*ETIOLOGY/IMMUNOLOGY/THERAPY B-Lymphocytes/IMMUNOLOGY Comparative Study Human HTLV-BLV Viruses/ISOLATION & PURIF Immune Tolerance Interleukin-2/BIOSYNTHESIS Male Support, U.S. Gov't, P.H.S. T-Lymphocytes/IMMUNOLOGY JOURNAL ARTICLE REVIEW

KWDacquiredimmunodeficiencysyndrome/KWDetiology/immunology/therapyb-lymphocytes/immunologycomparativestudyhumanhtlv-blvviruses/isolation&purifimmunetoleranceinterleukin-2/biosynthesismalesupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/immunologyjournalarticlereview
850228
M8520032

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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