Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
Lymphadenopathy-associated viral antibody in AIDS. Immune correlations and definition of a carrier state.
N Engl J Med. 1984 Nov 15;311(20):1269-73. Unique Identifier : AIDSLINE MED/85036508 Laurence J; Brun-Vezinet F; Schutzer SE; Rouzioux C; Klatzmann D; Barre-Sinoussi F; Chermann JC; Montagnier L
Abstract:
We investigated whether serologic evidence of lymphadenopathy-associated virus (LAV), an exogenous human T-cell lymphotropic and cytopathic retrovirus, correlated with the acquisition and transmission of the acquired immunodeficiency syndrome (AIDS). Serum from 17 of 25 patients with AIDS contained circulating IgG anti-LAV antibody (all of 5 adults with cancer and 6 of 12 adults and 6 of 8 children with opportunistic infections, with or without Kaposi's sarcoma). All of eight homosexual men with generalized lymphadenopathy or the AIDS-related complex and five homosexual men with AIDS prodromes who subsequently had AIDS were also seropositive. The anti-LAV antibody was not found in 99 of 100 healthy blood donors or in 23 patients with genetic immunodeficiencies, supporting the contention that LAV is unlikely to represent simply another opportunistic microorganism. An AIDS carrier state was indicated by the probable transfer of LAV from asymptomatic, immunologically competent mothers to their offspring. These data offer a basis for the hypotheses that LAV is a marker for AIDS, may be carried and transmitted in the absence of clinical findings or in vitro T-cell abnormalities, and is probably an etiologically important agent in AIDS and its prodromes.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/TRANSMISSION Adult Antibodies, Viral/*ANALYSIS Blood Donors Candidiasis/IMMUNOLOGY Carrier State/*IMMUNOLOGY Child Female Homosexuality Human HTLV-BLV Viruses/*IMMUNOLOGY Infant Lymphatic Diseases/IMMUNOLOGY/*MICROBIOLOGY Male Pneumonia, Pneumocystis carinii/IMMUNOLOGY Sarcoma, Kaposi's/IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.
AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.
Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
