Prog Cancer Res Ther; 27:225-34 1984. Unique Identifier : AIDSLINE ICDB/85603736
Filipovich AH; Zerbe D; Spector BD; Kersey JH; Immunodeficiency Cancer Registry, University of Minnesota; Hospitals, Minneapolis, MN 55455
This chapter presents descriptive data regarding host and tumor characteristics for cases of lymphomas occurring in immunodeficient patients reported to the Immunodeficiency Cancer Registry (ICR) and to the Denver Tumor Transplant Registry (DTTR). The study covers 385 cases of cancer in naturally immunodeficient patie
Prog Cancer Res Ther; 27:235-57 1984. Unique Identifier : AIDSLINE ICDB/85603737
Purtilo D; Harada S; Bechtold T; Yetz J; Rogers G; Seshi B; Department of Pathology, University of Nebraska Medical Center,; Omaha, NB 68105
Inherited and acquired immunodeficiencies are postulated to be involved in a number of diseases produced by Epstein-Barr Virus (EBV), especially B-cell malignant lymphomas. The X-linked lymphoproliferative syndrome (XLP) predisposes patients to EBV infections, possibly by suppressing or destroying certain T-cell popul
The effect of serum from patients with acquired immune deficiency syndrome (AIDS) on cultures of normal human peripheral blood mononuclear cells stimulated with phytohemagglutinin (PHA) has been studied. It has been found that AIDS sera are inhibitory when compared with control sera from healthy individuals. The inhib
Increased use of open lung biopsy in the search for a treatable etiology of acute interstitial pneumonitis (AIP) in immunocompromised patients is based on the assumption that examination and cultures from biopsy specimens will yield significant information leading to beneficial treatment of the condition. To assess th
Bone marrow biopsy findings in 32 homosexual patients with the acquired immunodeficiency syndrome (AIDS) or prodromal AIDS are described. A high incidence (38 per cent) of nonparatrabecular lymphohistiocytic infiltrations containing irregular small lymphocytes was observed, as well as the presence of diffuse bone marr
Isospora belli, like Cryptosporidium sp., a sporozoan parasite of the small intestine, has been isolated from both immunodeficient and immunologically normal persons. In immunocompetent persons the infection may be asymptomatic; it frequently causes mild and self-limited diarrhea. The spectrum of the disease in person
A new biphasic medium consisting of a 7H11 agar slant and brain heart infusion broth liquid phase has been used for the past 10 months at the University of California at Los Angeles for isolation of Mycobacterium avium complex from blood. In 12 patients whose blood cultures were grown on this medium, the median time f
An epidemic of disseminated Kaposi s sarcoma in male homosexuals has recently been described. Forty-one evaluable patients with epidemic Kaposi s sarcoma were treated with etoposide. The majority of these patients had early stage disease, no prior opportunistic infections, and no prior therapy. Twelve patients (30%) a
Med Hypotheses. 1984 Aug;14(4):347-51. Unique Identifier : AIDSLINE MED/85035934
Kelly TA
AIDS could be caused by a mutant hepatitis B virus or even a prion-like agent. Hepatitis B, as a retro-like virus, might induce cancerous cells, which, like other malignant cells, could produce substances that inhibit macrophages and their activation of T-cells. Hepatitis B, by reverse transcription, might become a pr
Vogt M; Luthy R; Oelz O; Ferber T; Bettex JD; Joller H; Joller P; Frick P; Siegenthaler W
Observations of 12 patients with AIDS at this institution from March 1981 to April 1984 are reported. Ten patients were homosexuals and two were bisexual. The majority had travelled abroad (USA, Haiti ) and reported multiple anonymous sexual contracts. Eleven patients reported sympto
Am J Med. 1984 Oct 30;77(4D):28-33. Unique Identifier : AIDSLINE MED/85043891
Dreizen S
Candidiasis is, by far, the most common mycotic infection of the human oral cavity. The usually manifested clinical expression of oral candidiasis at all ages from the newborn to the elderly is thrush . Other forms that affect the mouth include acute atrophic candidiasis associa
Am J Med. 1984 Nov;77(5):797-804. Unique Identifier : AIDSLINE MED/85043903
Schran HF; Hassel AE; Raskova J; Raska K Jr
It has been postulated that the acquired immune deficiency syndrome (AIDS) may be a result of the systemic presence of an immunosuppressive cyclosporine-like molecule released in chronic fungal infections. This possibility was examined by analysis of blood, plasma, or serum samples obtained from AIDS patients, from su
Am J Med. 1984 Nov;77(5):957-60. Unique Identifier : AIDSLINE MED/85043929
Schlanger G; Lutwick LI; Kurzman M; Hoch B; Chandler FW
A patient with the acquired immune deficiency syndrome and Legionella pneumophila infection of the maxillary sinus is described. The organism was identified by direct immunofluorescence staining of sinus tissue. Because the Legionella species are intracellular pathogens, it is not surprising that this patient with a c
Am J Ophthalmol. 1984 Nov;98(5):590-601. Unique Identifier : AIDSLINE MED/85044044
Newsome DA; Green WR; Miller ED; Kiessling LA; Morgan B; Jabs DA; Polk BF
Twelve of 13 patients with the acquired immune deficiency syndrome exhibited ophthalmoscopically detectable retinal findings, including cotton-wool spots, hemorrhages, Roth spots, and microvascular changes. When we used fluorescein angiography, we detected focal nonperfusion and microvascular changes in all 13 of our
Merl S; Kloster B; Moore J; Hubbell C; Tomar R; Davey F; Kalinowski D; Planas A; Ehrlich G; Clark D; et al
Modifying previously reported techniques, we attempted to increase the efficiency of human T cell leukemia-lymphoma virus (HTLV) transformation of human T lymphocytes. Lethally irradiated donor cells (DCs) were cultured with target mononuclear cells (TMCs). DCs included ten HTLV+ T cell lines with varying degrees of v
Low levels of serum complement subcomponent C1q may accompany primary humoral immunodeficiency diseases such as sex-linked agammaglobulinemia, severe combined immunodeficiency, and common varied immunodeficiency. This selective depression of C1q is proportional to the degree of hypogammaglobulinemia, and is corrected
During the past three years, an epidemic of acquired immunodeficiency syndromes (AIDS) involving the presence of specific forms of cancer (notably Kaposi s sarcoma) and infection (e.g., pneumocystis carinii) ordinarily seen only in severely immunosuppressed hosts has occurred among active homosexuals, Haitian immigran
Valone FH; Payan DG; Abrams DI; Dohlman JG; Goetzl EJ
The possibility that cyclooxygenase products of arachidonic acid might contribute to the defective T lymphocyte function of homosexual men with the reactive lymph node syndrome was examined in vitro. T lymphocyte proliferation, assessed by the uptake of [3H]thymidine after the addition of phytohemagglutin, was 72,870
Pass HI; Potter DA; Macher AM; Reichert C; Shelhammer JH; Masur H; Ognibene F; Gelmann E; Lane HC; Fauci A; et al
The acquired immune deficiency syndrome is characterized by the development of multiple recurrent opportunistic infections or unusual neoplasms in individuals with no prior history of immune suppression. This report summarizes the thoracic diseases encountered in such patients before after death and the role of diagno
The acquired immune deficiency syndrome (AIDS) is characterized by the development of Kaposi s sarcoma and several opportunistic infections including pneumonia caused by Pneumocystis carinii. As a staining method for Pneumocystis carinii, the methenamine-silver nitrate method has been used routinely. Most of fungi can
Am J Med. 1984 Oct 30;77(4D):1-12. Unique Identifier : AIDSLINE MED/85043888
Kirkpatrick CH
The immune system contains multiple components that provide protection against specific groups of microorganisms. The degree of specialization of function is clearly illustrated in patients with immunodeficiency syndromes in whom the nature of the defect determines the sites of the infections and the susceptibility to
Ann Intern Med. 1984 Dec;101(6):757-63. Unique Identifier : AIDSLINE MED/85045132
Pahwa SG; Quilop MT; Lange M; Pahwa RN; Grieco MH
Patients with the acquired immunodeficiency syndrome manifest a wide spectrum of immunologic abnormalities. Polyclonal and antigen-specific differentiation of B lymphocytes into immunoglobulin- and antibody-secreting cells was studied in vitro in three groups of homosexual volunteers: asymptomatic men; men who were sy
Pneumonia unresponsive to antibacterial agents in patients with acquired immune deficiency syndrome (AIDS) has become a new indication for lung biopsy. In 14 patients, transbronchial or open-lung biopsy demonstrated Pneumocystis carinii. An additional 12 patients, who were immunosuppressed after renal transplantation,
We measured serum interferon (IFN) levels and leukocyte IFN production in vitro in homosexual men with AIDS or generalized lymphadenopathy and in asymptomatic homosexual or heterosexual men. Acid-labile interferon alpha was detected in the serum of two patients with AIDS and in three out of nine patients with lymphade
Five children presented with focal seizures and neurological deficits that progressed over a span of months to years. Three had temporal lobectomy to control seizures, one underwent temporal lobe biopsy, and the fifth, who suffered from immunodeficiency, had an occipital lobectomy to remove a mass. Two of the children
Thirty patients with acquired immunodeficiency syndrome were examined by computed tomography. In addition to systemic disease, these patients had a variety of neurologic symptoms and signs. Cerebral toxoplasmosis (six cases) was generally manifested by ring-enhancing lesions with surrounding decreased attenuation. Lym
Med Hypotheses. 1984 Aug;14(4):423-33. Unique Identifier : AIDSLINE MED/85035944
Cathcart RF 3d
My previous experience with the utilization of ascorbic acid in the treatment of viral diseases led me to hypothesize that ascorbate would be of value in the treatment of AIDS (acquired immune deficiency syndrome). Preliminary clinical evidence is that massive doses of ascorbate (50-200 grams per 24 hours) can suppres
The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36
5 Nucleotidase (5 NT) is an ectoenzyme associated with the plasma membrane of most mammalian cells. Low 5 NT activity has been observed in peripheral blood lymphocytes from patients with immunodeficiency states. 5 NT activity was measured in null and T-enriched lymphocytes from asymptomatic homosexual men and from 20
Adult T-cell leukemia-associated antigen (ATLA), a human retrovirus-associated antigen, and anti-ATLA antibodies were examined in 52 cases of T-cell malignancies in the Nagasaki district in southwestern Japan , which is known to be an ATL endemic area. These T-cell malignancies inclu
Simian sarcoma virus-transformed NIH 3T3 (SSV-NIH 3T3) and SSV-NRK cells secrete a potent growth-promoting activity identical with the platelet-derived growth factor (PDGF) in mitogenic assays. The secreted activity is blocked by anti-PDGF antisera and competes with 125I-PDGF for receptor binding, suggesting that the
The human sis proto-oncogene contains the coding sequence for one of two polypeptide chains present in preparations of biologically active human platelet-derived growth factor (PDGF). A human clone, c-sis clone 8, which contains all of the v-sis-related sequences present in human DNA, was transcriptionally inactive wh
Clinical trials using interleukin 2 as a therapeutic immunomodulating agent in patients with acquired immunodeficiency syndrome have recently begun. In this article we present data from studies which indicate the ability of interleukin 2 in vitro to augment clinically important cytotoxic immune responses in lymphocyte
Int J Cancer. 1984 Oct 15;34(4):501-6. Unique Identifier : AIDSLINE MED/85029460
Merino F; Robert-Guroff M; Clark J; Biondo-Bracho M; Blattner WA; Gallo RC
Serum samples of 769 healthy Venezuelan donors were assayed for natural antibodies to HTLV-I by the ELISA technique. Specific HTLV-I antibody prevalence was 6.8% but varied from 1% in Caracas to 13.7% in the Amazonas region and the State of Zulia. Adults infected with Trypanosoma cruzi had the highest HTLV-I antibody
Int J Cancer. 1984 Oct 15;34(4):513-7. Unique Identifier : AIDSLINE MED/85029462
Hoshino H; Tanaka H; Shimotohno K; Miwa M; Nagai M; Shimoyama M; Sugimura T
Peripheral blood lymphocytes of domestic cats were co-cultivated with lethally irradiated MT-2 cells, which produced human T-cell leukemia virus type 1 (HTLV-I). Two cat lymphoid cell lines, CaL-1 and CaL-2, established and maintained without exogenously added T-cell growth factor, were characterized after more than 6
Health care personnel are exposed to infectious diseases in the community as well as in the health care setting when they care for patients with transmissible conditions. Pregnant nurses, physicians and others face an additional risk--that of exposing their unborn children to some of these infections. Risk factors var
Alpha- and gamma-interferon (IFN) production by peripheral blood mononuclear cells (PBMC) from 18 patients affected by primary immunodeficiency syndromes was examined and compared with that of 20 normal donors. Patients included 8 with common variable immunodeficiency (CVI), 2 with congenital agammaglobulinemia, 4 wit
The acquired immunodeficiency syndrome (AIDS) is a devastating disease which continues to claim the lives of most of its victims. Despite the media s silence, AIDS has in no way disappeared. Over 4,400 cases have been reported thus far and many more new cases are reported each week nationwide. The ocular manifestation
An adult T-cell leukemia virus (ATLV) producer cell line (TL-Su) derived from a healthy ATLV-carrier, was used for virus-induced transformation of normal human T-cells. The transformation was carried out on microplates by co-cultivation of a limiting number of normal peripheral blood leukocytes (PBL) as transformed ta
Koyanagi Y; Yamamoto N; Kobayashi N; Hirai K; Konishi H; Takeuchi K; Tanaka Y; Hatanaka M; Hinuma Y
Human B-cell lines, designated ATLB cell lines, were spontaneously established from peripheral blood of adult T-cell leukaemia (ATL) patients. The cell lines consistently expressed ATL-associated antigen (ATLA) and Epstein-Barr virus-associated nuclear antigen (EBNA). A cloned ATLB line, designated ATLB 2, showed that
Letvin NL; Daniel MD; Sehgal PK; Chalifoux LV; King NW; Hunt RD; Aldrich WR; Holley K; Schmidt DK; Desrosiers RC
The naturally occurring immunodeficiency syndrome of macaque monkeys is an important animal model for the acquired immunodeficiency syndrome in humans. A new type D retrovirus, distinct from Mason- Pfizer monkey virus, has been isolated from affected animals at the New Engl
Med Hypotheses. 1984 Sep;15(1):39-46. Unique Identifier : AIDSLINE MED/85035950
Marcus SG
This hypothesis suggests that repeated viral infections disrupt the biosynthesis of P.G.E. 1 and nullify a major system by which t lymphocytes are regulated. It is hypothesized that a breakdown of P.G.E. 1 synthesis is responsible for the acquired immunodeficiency syndrome and the frequently associated Kaposi s sarcom
Med J Aust. 1984 Oct 27;141(9):569-73. Unique Identifier : AIDSLINE MED/85036005
The frequency of specific clinical, epidemiological, and immunological characteristics associated with the possible development of AIDS was established in a cohort of homosexual men living in metropolitan Sydney. During a six-month period, 289 subjects were enrolled into a prospective study. The initial findings in th
Med J Aust. 1984 Oct 27;141(9):573-8. Unique Identifier : AIDSLINE MED/85036006
Hill AB; May W; Kaminsky LS; Levy JA; Penny R; Cooper DA
Fifty-six patients were referred in 1983 for assessment in connection with AIDS and related disorders. Clinical and immunological classification of patients was carried out according to the NHMRC criteria. The presence of antibodies to an AIDS-associated retrovirus (ARV) was determined in some patients. Of the 32 pati
Med J Aust. 1984 Oct 27;141(9):579-82. Unique Identifier : AIDSLINE MED/85036007
Cooper DA; Gold J; May W; Kaminsky LS; Penny R; Levy JA
The sexual contacts of a patient with acquired immune deficiency syndrome were traced, and clinical, immunological, and serological evidence was obtained and evaluated. It was determined that the patient acquired the disease from a homosexual man who had no symptoms, but in whom laboratory evidence of immunodeficiency
The acquired immunodeficiency syndrome (AIDS) is a new disease characterized by severe dysfunction of both the T cell and B cell systems, occurring in previously healthy individuals. Affected individuals may have recurrent and chronic opportunistic infections and/or Kaposi s sarcoma or other malignancy. Analysis of th
We investigated whether serologic evidence of lymphadenopathy-associated virus (LAV), an exogenous human T-cell lymphotropic and cytopathic retrovirus, correlated with the acquisition and transmission of the acquired immunodeficiency syndrome (AIDS). Serum from 17 of 25 patients with AIDS contained circulating IgG ant
Palestine AG; Rodrigues MM; Macher AM; Chan CC; Lane HC; Fauci AS; Masur H; Longo D; Reichert CM; Steis R; et al
Forty patients with acquired immunodeficiency syndrome (AIDS) were examined for ocular abnormalities. Twenty of these patients died and the eyes were obtained for culture and histopathologic examination. These patients have multiple opportunistic infections and neoplasms as the result of a severe depression of cellula
Chronic hepatitis occurring in patients with primary immunodeficiency disease is an uncommonly reported phenomenon. This study describes our experience with 3 patients with various immunologic abnormalities who developed chronic atypical lymphocytic infiltrates in the liver. There was a temporal relationship to Epstei
Proc Natl Acad Sci U S A. 1984 Nov;81(21):6657-61. Unique Identifier : AIDSLINE GENBANK/K02723
Shimotohno K; Wachsman W; Takahashi Y; Golde DW; Miwa M; Sugimura T; Chen IS
The nucleic acid sequence of the 3 region of human T-cell leukemia virus type II (HTLV-II) proviral DNA was determined using a HTLV-II proviral clone that could be recovered as infectious, transforming virus. The sequence data indicate a region of unknown function of approximately equal to 1.6 kilobase pairs in the 3
Peripheral blood leukocytes and saliva from 20 individuals, including four with the acquired immune deficiency syndrome (AIDS), ten with AIDS-related complex (ARC), and six healthy homosexual males at risk for AIDS, were compared as sources of transmissible human T-cell leukemia (lymphotropic) virus type III (HTLV-III
Science. 1984 Oct 26;226(4673):449-51. Unique Identifier : AIDSLINE MED/85040341
Zagury D; Bernard J; Leibowitch J; Safai B; Groopman JE; Feldman M; Sarngadharan MG; Gallo RC
Epidemiological results suggest that the etiological agent of the acquired immune deficiency syndrome (AIDS) is transmitted primarily through blood products, semen, and saliva. There is evidence that the human T-cell leukemia (lymphotropic) virus type III (HTLV-III) is this agent. HTLV-III has been isolated repeatedly
Science. 1984 Oct 26;226(4673):451-3. Unique Identifier : AIDSLINE MED/85040342
Ho DD; Schooley RT; Rota TR; Kaplan JC; Flynn T; Salahuddin SZ; Gonda MA; Hirsch MS
Human T-lymphotropic virus type III (HTLV-III) is the probable etiologic agent for the acquired immune deficiency syndrome (AIDS). HTLV-III was isolated from semen and blood of a healthy homosexual man whose serum contains antibodies to HTLV-III. The finding of virus in semen supports epidemiologic data that suggest t
Science. 1984 Oct 26;226(4673):459-62. Unique Identifier : AIDSLINE MED/85040344
Popovic M; Flomenberg N; Volkman DJ; Mann D; Fauci AS; Dupont B; Gallo RC
Two functionally different types of human T-cell clones, one with helper function and two with specific activity, were infected with different isolates of HTLV-I and HLTV-II. Both types of human T cells showed alterations in specific function after infection with either of the HTLV subgroups. Before HTLV infection, th
Science. 1984 Nov 2;226(4674):549-52. Unique Identifier : AIDSLINE MED/85040357
Alter HJ; Eichberg JW; Masur H; Saxinger WC; Gallo R; Macher AM; Lane HC; Fauci AS
Two of three chimpanzees given plasma from patients with acquired immune deficiency syndrome (AIDS) or pre-AIDS showed serum antibodies to type III human T-cell leukemia virus (HTLV-III) 10 to 12 weeks after transfusion. One animal also developed lymphadenopathy, transient depression of the ratio of T4 to T8 lymphocyt
Two regions of the gene for the human T-cell leukemia virus subgroup I (HTLV-I) envelope were expressed in Escherichia coli by use of the vector pJLA16. One corresponds to the carboxyl terminal region of the major envelope protein p46, and the other corresponds to the transmembrane protein p21E. Reactivity of the expr
We present data on 14 patients with chronic symptoms of disabling fatigue in association with serologic evidence of active Epstein-Barr virus (EBV) infection. Two thirds were women, and the average age at onset was 29.6 years. Forty-three percent were known to have had previous infectious mononucleosis, but the usual
The env gene of a bovine leukemia virus (BLV) tumor-derived proviral DNA clone has been located by comparison of the translated DNA sequence with amino acid sequence data on purified gp60 and p30env (A. M. Schultz, T. D. Copeland, and S. Oroszlan (1984) Virology 135, 417-427). There is a continuous open reading frame
Virology. 1984 Oct 30;138(2):373-8. Unique Identifier : AIDSLINE MED/85042094
Komuro A; Watanabe T; Miyoshi I; Hayami M; Tsujimoto H; Seiki M; Yoshida M
Lymphoid cell lines were established from five different species of monkeys which were positive in antibodies cross-reactive with human T-cell leukemia virus type I (HTLV-I) and were shown to contain provirus sequences homologous to HTLV-I. Gene-specific probes of HTLV-I, gag, pol, env, pX, and LTR, hybridized efficie
The hypothesis is presented that a human T-cell leukemia virus (HTLV) or a related agent produces a lytic response of T cells manifested by the acquired immune deficiency syndrome (AIDS) and a proliferative response represented by the adult leukemia/lymphoma (ATL) syndromes. The sequence or cascade of T-cell events fo
Cutaneous T-cell lymphomas (CTCL) are neoplasias of mature T-cells and comprise Sezary syndrome, mycosis fungoides and some cases of lymphomatoid papulosis. Clinically this group of disorders differ from the more aggressive neoplasias of mature T-cells known as adult T-cell leukemia/lymphoma and T-cell lymphosarcoma l
The cellular composition and T-lymphocyte subpopulations of bronchoalveolar lavage (BAL) fluid from 12 patients with acquired immunodeficiency syndrome (AIDS) and active pneumonitis were examined. Differential cell counts were performed on BAL specimens from each patient and from 25 normal subjects. The BAL and periph
Bonner JR; Alexander WJ; Dismukes WE; App W; Griffin FM; Little R; Shin MS
The ongoing epidemic of acquired immune deficiency syndrome (AIDS) has affected homosexual men, intravenous (IV) drug abusers, Haitians, hemophiliacs, and others. Defects in cell-mediated immunity place these patients at risk for opportunistic infections. We recently saw three men from Alabama with disseminated infect
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