THE PRELEUKEMIC STATE IN VIRUS-INDUCED LEUKEMIA NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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THE PRELEUKEMIC STATE IN VIRUS-INDUCED LEUKEMIA

Life Sci Res Rep; 30:223-34 1985. Unique Identifier : AIDSLINE ICDB/85615782
Essex M; Dept. of Cancer Biology, Harvard Univ., Sch. of Public Health,; Boston, MA 02115

Abstract: Feline leukemia, bovine leukemia, and human adult T-cell leukemia are reviewed, with particular reference to the existence of a preleukemic state. The retroviruses associated with these naturally occurring leukemias share common features such as the following: they are horizontally acquired; most infected individuals do not develop leukemia; when leukemia (or lymphoma) does occur, it is only after a prolonged and variable induction period; the tumors that develop are monoclonal; and, despite the low rate of leukemia incidence in infected animals, most or all develop persistent latent infections in a limited population of hematopoietic cells. Clear differences among these viral systems also exist. For example, in the feline leukemia virus (FeLV) system, high levels of free virus are present in the circulatory system, which is not the case in bovine leukemia virus (BLV)-infected cattle or human adult T-cell leukemia virus (HTLV)-infected persons. In cattle the BLV-associated tumors are of B-cell type, but in humans and cats the retrovirus-associated tumors are primarily of T-cell type. In FeLV-infected cats and in humans infected with HTLV, there are indications of immunosuppression, which has not been reported for BLV-infected cattle. (35 Refs)
Keywords: Animal Cats Cattle Cell Line Human HTLV-BLV Viruses Leukemia Virus, Bovine Leukemia Virus, Feline Leukemia, Experimental/ETIOLOGY Preleukemia/ETIOLOGY *Retroviridae Infections MEETING PAPER

KWDanimalcatscattlecelllinehumanhtlv-blvvirusesleukemiavirus,bovineleukemiavirus,felineleukemia,experimental/etiologypreleukemia/etiologyKWDretroviridaeinfectionsmeetingpaper
851230
M85C0208

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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