THE RECEPTOR-MEDIATED LEUKEMOGENESIS HYPOTHESIS: A MODEL OF RETROVIRAL ONCOGENESIS BY VIRAL STIMULATION OF CELL-SURFACE RECEPTORS NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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THE RECEPTOR-MEDIATED LEUKEMOGENESIS HYPOTHESIS: A MODEL OF RETROVIRAL ONCOGENESIS BY VIRAL STIMULATION OF CELL-SURFACE RECEPTORS

Life Sci Res Rep; 30:235-49 1985. Unique Identifier : AIDSLINE ICDB/85615783
Weissman IL; McGrath MS; Tamura G; Lab. of Experimental Oncology, Dept. of Pathology, Stanford Univ.; Sch. of Medicine, Stanford, CA 94305

Abstract: Slowly-transforming retroviruses, models for their oncogenic action, and the receptor-mediated leukemogenesis hypothesis are first described. Results of experiments testing various predictions inherent in the receptor-mediated leukemogenesis hypothesis were as follows: each T cell lymphoma expresses surface receptors highly specific for the virus that is produced by it; the virus receptor is a marker for leukemia cells and distinguishes such cells from preleukemic cells in the same thymus; and virus receptor binding may regulate lymphoma proliferation. Virus receptors on B cell lymphomas in mice (BCL1) and chickens (bursal lymphoma lines) have been demonstrated. Preliminary experiments demonstrated possible human T-cell leukemia virus (HTLV)-specific receptors on HTLV-producing cells. Problems remain with the receptor-mediated leukemogenesis hypothesis. The critical test that is needed is to determine whether the isolated virus receptor from tumor models like murine T-cell lymphoma (C6VL) is the antigen-specific T cell (or interleukin-2) receptor, and whether transfection of receptor structures to normal T cell clones will endow these cells with the property of leukemic transformation in the presence of the virus from the transfection donor cell. (21 Refs)
Keywords: Animal B-Lymphocytes/IMMUNOLOGY Cell Transformation, Neoplastic Chickens Human Leukemia/*PHYSIOPATHOLOGY Mice Mice, Inbred BALB C Receptors, Antigen/PHYSIOLOGY Receptors, Cell Surface/*PHYSIOLOGY Retroviridae Infections/*PHYSIOPATHOLOGY Slow Virus Diseases/PHYSIOPATHOLOGY T-Lymphocytes/IMMUNOLOGY MEETING PAPER

KWDanimalb-lymphocytes/immunologycelltransformation,neoplasticchickenshumanleukemia/KWDphysiopathologymicemice,inbredbalbcreceptors,antigen/physiologyreceptors,cellsurface/KWDphysiologyretroviridaeinfections/KWDphysiopathologyslowvirusdiseases/physiopathologyt-lymphocytes/immunologymeetingpaper
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M85C0207

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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