REGULATION OF HEMATOPOIETIC DIFFERENTIATION AND ITS DISRUPTION NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


REGULATION OF HEMATOPOIETIC DIFFERENTIATION AND ITS DISRUPTION

Life Sci Res Rep; 30:251-60 1985. Unique Identifier : AIDSLINE ICDB/85615784
Fathman CG; Ganser A; Iscove NN; Karpowicz M; Kishimoto T; Klein E; Krammer PH; Lilly F; Melchers F; Metcalf D; et al; Dept. of Medicine, S102A, Stanford Univ. Medical Sch., Stanford,; CA 94305

Abstract: Discussions from a workshop on the regulation of hematopoietic differentiation are summarized in this report. Basic questions concerning normal pathways of hematopoietic growth and differentiation consist of the following: what are the normal pathways of hematopoietic differentiation, and are growth factors involved in autocrine function in leukemia? The current status of hematopoietic factor characterization based on sequencing data and studies involving antibodies and monoclonal antibodies is reviewed. Leukemogenesis appears to be a multi-step process resulting in apparent maturational arrest and uninhibited proliferation of cells. It is not possible yet to understand either the number or the sequence of 'preleukemic' events. Several technical and methodological achievements will be necessary for studies of the sequence of normal lymphoid and hematopoietic differentiation and for studies of 'preleukemic' events. Among these needed achievements are the following: monoclonals and/or markers that can select lineage-specific progenitor cells and repopulating cells; cloned growth and maturation factors; cloned cells of myeloid and lymphoid lineages; an assay of c-myc translocations among non-transformed cells; systems for transfection of normal human hematopoietic cells; and knowledge of intracellular signals following growth factor receptor interactions. (4 Refs)
Keywords: Animal Growth Substances/*PHYSIOLOGY *Hematopoiesis Hematopoietic Stem Cells/*PHYSIOLOGY Human HTLV-BLV Viruses/GENETICS Leukemia/PHYSIOPATHOLOGY Oncogenes Retroviridae Infections/PHYSIOPATHOLOGY MEETING PAPER

KWDanimalgrowthsubstances/KWDphysiologyKWDhematopoiesishematopoieticstemcells/KWDphysiologyhumanhtlv-blvviruses/geneticsleukemia/physiopathologyoncogenesretroviridaeinfections/physiopathologymeetingpaper
851230
M85C0206

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1985. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .