Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
Aggressive non-Hodgkin's lymphomas in immunocompromised homosexual males.
Blood. 1985 Sep;66(3):655-9. Unique Identifier : AIDSLINE MED/85280849 Kalter SP; Riggs SA; Cabanillas F; Butler JJ; Hagemeister FB; Mansell PW; Newell GR; Velasquez WS; Salvador P; Barlogie B; et al
Abstract:
During the period from 1981 through 1984, 14 immunocompromised homosexual males with intermediate or high-grade non-Hodgkin's lymphoma were seen at University of Texas M.D. Anderson Hospital and Tumor Institute. Six patients had diffuse large-cell lymphoma, seven had diffuse undifferentiated lymphoma, and one had unclassifiable lymphoma that suggested large-cell lymphoma. Eight patients had the acquired immunodeficiency syndrome (AIDS) and five had the AIDS-related complex. Kaposi's sarcoma was initially present in four patients and developed later in two others. The patients with diffuse large-cell lymphoma were characterized by more severely altered immune parameters, multicentric brain mass lesions, pretherapy opportunistic infections, lower performance status, poor response to therapy, and death in all within six months. The undifferentiated lymphoma group had preceding generalized reactive lymphadenopathy, less severe immune dysfunction, and excellent response to combination chemotherapy, with survival time greater than 19 months in three patients. Twelve of the patients had extranodal sites of lymphoma at presentation. There is a definite trend for the development of aggressive non-Hodgkin's lymphomas with unusual sites of extranodal involvement in immunocompromised homosexual males, with the potential for good tolerance to combination chemotherapy and improved survival in the subgroup without severe concomitant opportunistic infections.
Keywords: Abscess/ETIOLOGY Adult Bone Marrow/PATHOLOGY Brain/PATHOLOGY Candidiasis/ETIOLOGY *Homosexuality Human Immunity, Cellular Immunologic Deficiency Syndromes/*COMPLICATIONS Lymph Nodes/PATHOLOGY Lymphoma/ETIOLOGY/IMMUNOLOGY/*PATHOLOGY Male Middle Age Mycobacterium Infections/ETIOLOGY Neoplasm Invasiveness Support, U.S. Gov't, P.H.S. Toxoplasmosis/ETIOLOGY JOURNAL ARTICLE
AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.
AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.
Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.
