Defective humoral immunity in pediatric acquired immune deficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Defective humoral immunity in pediatric acquired immune deficiency syndrome.

J Pediatr. 1985 Sep;107(3):352-7. Unique Identifier : AIDSLINE MED/85292354
Bernstein LJ; Ochs HD; Wedgwood RJ; Rubinstein A

Abstract: Specific antibody production was assessed in six young children with the acquired immune deficiency syndrome (AIDS). All patients were immunized with bacteriophage phi X 174, a T cell-dependent neoantigen. In addition, antibody responses to pneumococcal vaccine and tetanus toxoid, lymphocyte responses to mitogens, and serum immunoglobulin levels were determined. Polyclonal hypergammaglobulinemia was documented in three patients. Responses to bacteriophage phi X 174 were abnormal in all patients: primary responses were blunted, secondary responses were markedly decreased, and the class switch (IgM-IgG) was absent in five of six patients. Antibody formation to pneumococcal vaccine and tetanus toxoid was also diminished. Lymphocyte mitogenic responses to phytohemagglutinin, concanavalin A, pokeweed mitogen, and staphylococcal Cowan A were generally decreased. These findings confirm that pediatric patients with AIDS have significant abnormalities in humoral immunity. Dysfunction of both T cells and B cells plays a role in the resultant poor specific antibody production.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Antibodies, Bacterial/*BIOSYNTHESIS Antigens, Bacterial/IMMUNOLOGY Bacterial Vaccines/IMMUNOLOGY Case Report Child, Preschool Female Human IgG/BIOSYNTHESIS IgM/BIOSYNTHESIS Immunity, Cellular Infant Male Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Phages/IMMUNOLOGY Tetanus Toxoid/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyantibodies,bacterial/KWDbiosynthesisantigens,bacterial/immunologybacterialvaccines/immunologycasereportchild,preschoolfemalehumanigg/biosynthesisigm/biosynthesisimmunity,cellularinfantmalesupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-phages/immunologytetanustoxoid/immunologyjournalarticle
851230
M85C0185

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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