Reversal of T-cell unresponsiveness by T-cell-conditioned medium in retrovirus MAV-2-O-induced immunosuppression in chickens. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Reversal of T-cell unresponsiveness by T-cell-conditioned medium in retrovirus MAV-2-O-induced immunosuppression in chickens.

Cancer Res. 1985 Oct;45(10):4871-5. Unique Identifier : AIDSLINE MED/85282211
Boni-Schnetzler M; Boni J; Franklin RM

Abstract: Polyclonal activation of T-cells with concanavalin A has been used as an in vitro test system to study immunosuppression induced by the avian retrovirus MAV-2-O. The mitogenic responsiveness of peripheral blood lymphocytes from infected chickens was only weakly suppressed, that of spleen lymphocytes was highly suppressed. Addition of conditioned media rich in T-cell growth factor (TCGF) activity to cultures of infected birds resulted in a reconstitution of the suppressed mitogenic responsiveness up to the level found in lymphocyte cultures from normal chickens. This indicates that the defect of the observed immunopathology is not at the level of responding T-cells. Measurements of TCGF production always showed reduced TCGF levels in the suppressed cultures suggesting that there is a defect at the TCGF production level. This is further supported by the failure to reconstitute the suppressed mitogenic response with normal macrophages, which are involved in activation of TCGF producer T-cells.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY Animal Avian Leukosis/*IMMUNOLOGY Chickens Culture Media Human *Immune Tolerance Interleukin-2/ANALYSIS/BIOSYNTHESIS Lymphocyte Transformation Lymphocytes/ANALYSIS Macrophages/IMMUNOLOGY Spleen/ANALYSIS Support, Non-U.S. Gov't T-Lymphocytes/*IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/immunologyanimalavianleukosis/KWDimmunologychickensculturemediahumanKWDimmunetoleranceinterleukin-2/analysis/biosynthesislymphocytetransformationlymphocytes/analysismacrophages/immunologyspleen/analysissupport,non-uKWDsKWDgov'tt-lymphocytes/KWDimmunologyjournalarticle
851230
M85C0148

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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