Bronchoalveolar lavage cells and proteins in patients with the acquired immunodeficiency syndrome. An immunologic analysis. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Bronchoalveolar lavage cells and proteins in patients with the acquired immunodeficiency syndrome. An immunologic analysis.

Ann Intern Med. 1985 Oct;103(4):522-33. Unique Identifier : AIDSLINE MED/85305195
Young KR Jr; Rankin JA; Naegel GP; Paul ES; Reynolds HY

Abstract: Several components of cellular and humoral immunity were examined in bronchoalveolar lavage fluid and blood of 15 patients with the acquired immunodeficiency syndrome, and the results were compared to data from 25 healthy controls (including 5 asymptomatic homosexual men). Compared with that of controls, bronchoalveolar lavage fluid from patients tended to have more lymphocytes and significantly more neutrophils; a lower OKT4/OKT8 ratio, due to an increase in total OKT8 cells; and normal total OKT4 cell counts, despite a significant decrease in numbers of OKT4 cells in peripheral blood. Patients also had significantly more IgG-releasing cells and higher IgG levels than controls in lavage fluid. These data show that, in the lung lining fluid of patients with the acquired immunodeficiency syndrome, significant alterations in cellular and humoral immunity exist that differ in several important respects from immunity in controls and from corresponding changes in patients' peripheral blood.
Keywords: Acquired Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY/METABOLISM/ PATHOLOGY Adult Albumins/ANALYSIS Antibody Formation Blood Proteins/ANALYSIS Bronchi/ANALYSIS/*IMMUNOLOGY/PATHOLOGY Cell Count Female Human Immunity, Cellular Immunoglobulins/METABOLISM Irrigation Leukocyte Count Macrophages Male Middle Age Proteins/ANALYSIS Pulmonary Alveoli/ANALYSIS/*IMMUNOLOGY/PATHOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. T-Lymphocytes/CLASSIFICATION JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/blood/KWDimmunology/metabolism/pathologyadultalbumins/analysisantibodyformationbloodproteins/analysisbronchi/analysis/KWDimmunology/pathologycellcountfemalehumanimmunity,cellularimmunoglobulins/metabolismirrigationleukocytecountmacrophagesmalemiddleageproteins/analysispulmonaryalveoli/analysis/KWDimmunology/pathologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,non-pKWDhKWDsKWDsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/classificationjournalarticle
851230
M85C0141

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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