Therapeutic trial of interferon-gamma in patients with epidemic Kaposi's sarcoma. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Therapeutic trial of interferon-gamma in patients with epidemic Kaposi's sarcoma.

J Biol Response Mod. 1985 Aug;4(4):358-64. Unique Identifier : AIDSLINE MED/85291924
Krigel RL; Odajnyk CM; Laubenstein LJ; Ostreicher R; Wernz J; Vilcek J; Rubinstein P; Friedman-Kien AE

Abstract: An epidemic form of Kaposi's sarcoma associated with the acquired immune deficiency syndrome has been recently described. Seven homosexual men with biopsy-documented epidemic Kaposi's sarcoma were treated with a human interferon-gamma preparation. All patients had generalized disease. Only one patient had received prior chemotherapy, and one other patient had recovered from a prior opportunistic infection. Interferon-gamma was administered in a dose of 500,000 U intramuscularly daily, with two 10-day induction courses, separated by a 2-week medication-free period. This was followed by maintenance therapy in the same dose twice weekly. Toxicities consisted of a flu-like illness with high fevers, shaking chills, myalgias, and arthralgias. There were no complete or partial responses. All patients exhibited disease progression, with a rapid progression of previously stable disease necessitating discontinuation of therapy in three patients. We conclude that low doses of this human interferon-gamma preparation are ineffective in epidemic Kaposi's sarcoma.
Keywords: Adult Antibodies/ANALYSIS Clinical Trials Comparative Study Homosexuality Human Interferon Type II/IMMUNOLOGY/*THERAPEUTIC USE Male Middle Age Sarcoma, Kaposi's/IMMUNOLOGY/*THERAPY Skin Tests Support, U.S. Gov't, P.H.S. CLINICAL TRIAL JOURNAL ARTICLE

KWDadultantibodies/analysisclinicaltrialscomparativestudyhomosexualityhumaninterferontypeii/immunology/KWDtherapeuticusemalemiddleagesarcoma,kaposi's/immunology/KWDtherapyskintestssupport,uKWDsKWDgov't,pKWDhKWDsKWDclinicaltrialjournalarticle
851230
M85C0128

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