Antibody seronegative human T-lymphotropic virus type III (HTLV-III)-infected patients with acquired immunodeficiency syndrome or related disorders. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Antibody seronegative human T-lymphotropic virus type III (HTLV-III)-infected patients with acquired immunodeficiency syndrome or related disorders.

Blood. 1985 Sep;66(3):742-4. Unique Identifier : AIDSLINE MED/85280868
Groopman JE; Hartzband PI; Shulman L; Salahuddin SZ; Sarngadharan MG; McLane MF; Essex M; Gallo R

Abstract: The human T-lymphotropic virus type III (HTLV-III) is the primary cause of the acquired immunodeficiency syndrome (AIDS) and related disorders (ARC). Prior studies have reported that nearly all symptomatic patients with AIDS or ARC manifest antibody to HTLV-III. This observation has engendered efforts to screen for HTLV-III, especially prior to blood donation, with assays for antibody to HTLV-III. We report the first two cases, one with AIDS and one with ARC, that are HTLV-III virus positive but antibody negative. Accurate diagnosis of HTLV-III infection in some cases may require direct virus culture or tests for antigen. In addition, lack of HTLV-III antibody may indicate an atypical clinical course of AIDS.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adult Antibodies, Viral/*ANALYSIS Case Report Human HTLV-BLV Viruses/*IMMUNOLOGY/ISOLATION & PURIF Leukopenia/IMMUNOLOGY Lymphatic Diseases/IMMUNOLOGY Male Middle Age Retroviridae Infections/*IMMUNOLOGY Sarcoma, Kaposi's/IMMUNOLOGY Support, Non-U.S. Gov't Thrombocytopenia/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyadultantibodies,viral/KWDanalysiscasereporthumanhtlv-blvviruses/KWDimmunology/isolation&purifleukopenia/immunologylymphaticdiseases/immunologymalemiddleageretroviridaeinfections/KWDimmunologysarcoma,kaposi's/immunologysupport,non-uKWDsKWDgov'tthrombocytopenia/immunologyjournalarticle
851230
M85C0115

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