Division New York : AMA Membership Publications Division, American Management Association, c1985 81 p (AMA management briefing) Unique Identifier : AIDSLINE CAT/8509624
Chicago : Year Book Medical Publishers, c1985 39 p. : ill., port (Current problems in cancer, ISSN 0147-0272 ; v. 9, no. 1 (Jan. 1985)) Unique Identifier : AIDSLINE CAT/8508678
Genetic and Phenotypic Markers of Tumors. Aaronson SA, Frati L, Verna R, eds. New York, Plenum Press, p. 337-44, 1984.. Unique Identifier : AIDSLINE ICDB/85615482
Human T-cell leukemia/lymphoma virus (HTLV) is a family of related, human T-cell tropic retroviruses, consisting of at least two distinct subgroups, HTLV-I and HTLV-II. Molecular biological studies on HTLV are presented, focusing on a molecular epidemiological survey of human leukemias using cloned HTLV probes and on
Genetic and Phenotypic Markers of Tumors. Aaronson SA, Frati L, Verna R, eds. New York, Plenum Press, p. 345-55, 1984.. Unique Identifier : AIDSLINE ICDB/85615483
Fazio VM; Manzari V; Frati L; Franchini G; Wong-Staal F; Gallo RC; Istituto di Patologia Generale, Policlinico Umberto I, Universita; degli Studi di Roma, Italy
The transcription of human T lymphocytes infected by human T-cell leukemia/lymphoma virus (HTLV) was analyzed to investigate the influence of HTLV integration in neoplastic transformation and proliferation of T-cells and to detect gene(s) expressed at high levels in these cells. Messenger RNA (mRNA) was extracted and
Genetic and Phenotypic Markers of Tumors. Aaronson SA, Frati L, Verna R, eds. New York, Plenum Press, p. 357-72, 1984.. Unique Identifier : AIDSLINE ICDB/85615484
Certain clinical and laboratory features of the adult T-cell leukemia/lymphoma (ATLL) syndrome and human T-cell leukemia/lymphoma virus (HTLV) are summarized. A case history of a patient (pt) with the ATLL syndrome is presented. The pt, a 23-yr-old black woman, had a 2-mo history of wt loss, fatigue and lymphadenopath
Life Sci Res Rep; 30:223-34 1985. Unique Identifier : AIDSLINE ICDB/85615782
Essex M; Dept. of Cancer Biology, Harvard Univ., Sch. of Public Health,; Boston, MA 02115
Feline leukemia, bovine leukemia, and human adult T-cell leukemia are reviewed, with particular reference to the existence of a preleukemic state. The retroviruses associated with these naturally occurring leukemias share common features such as the following: they are horizontally acquired; most infected individuals
Life Sci Res Rep; 30:235-49 1985. Unique Identifier : AIDSLINE ICDB/85615783
Weissman IL; McGrath MS; Tamura G; Lab. of Experimental Oncology, Dept. of Pathology, Stanford Univ.; Sch. of Medicine, Stanford, CA 94305
Slowly-transforming retroviruses, models for their oncogenic action, and the receptor-mediated leukemogenesis hypothesis are first described. Results of experiments testing various predictions inherent in the receptor-mediated leukemogenesis hypothesis were as follows: each T cell lymphoma expresses surface receptors
Life Sci Res Rep; 30:251-60 1985. Unique Identifier : AIDSLINE ICDB/85615784
Fathman CG; Ganser A; Iscove NN; Karpowicz M; Kishimoto T; Klein E; Krammer PH; Lilly F; Melchers F; Metcalf D; et al; Dept. of Medicine, S102A, Stanford Univ. Medical Sch., Stanford,; CA 94305
Discussions from a workshop on the regulation of hematopoietic differentiation are summarized in this report. Basic questions concerning normal pathways of hematopoietic growth and differentiation consist of the following: what are the normal pathways of hematopoietic differentiation, and are growth factors involved i
Facchetti F; Zorzi M; Tardanico R; Salvi A; Zuccato F; Franceschini F; Cattaneo R; Callea F
Lymphocyte subsets were analyzed in peripheral blood and lymph nodes from a drug-addict with acquired immunodeficiency syndrome (AIDS) presenting with disseminated lymphadenopathic and oropharyngeal Kaposi s sarcoma. At the onset of disease, hypergammaglobulinemia, increase of OKT8+ T cell subset and reversal of OKT4/
Sera from 68 patients with acquired immunodeficiency syndrome and 135 controls were used to evaluate the indirect immunofluorescence and enzyme-linked immunosorbent assays for detection of antibodies to Pneumocystis carinii and a counterimmunoelectrophoresis assay for detection of circulating Pneumocystis antigen. Non
Kalter SP; Riggs SA; Cabanillas F; Butler JJ; Hagemeister FB; Mansell PW; Newell GR; Velasquez WS; Salvador P; Barlogie B; et al
During the period from 1981 through 1984, 14 immunocompromised homosexual males with intermediate or high-grade non-Hodgkin s lymphoma were seen at University of Texas M.D. Anderson Hospital and Tumor Institute. Six patients had diffuse large-cell lymphoma, seven had diffuse undiff
White DA; Gellene RA; Gupta S; Cunningham-Rundles C; Stover DE
Bronchoalveolar lavage (BAL) cell populations were determined in 47 immunosuppressed patients during episodes of pulmonary disease. Thirty six patients had AIDS and 11 had conventional causes of immunosuppression. Pulmonary disease was due to a variety of infectious and noninfectious causes and was similar in both gro
Das S; Bhattacharya S; Mukherjee K; Roychowdhury J
Two placental hormones (human chorionic gonadotropin and human chorionic somatotropin) were assayed in serum of patients bearing a wide variety of malignant tumours. The incidences of these hormones were found to be higher among female patients. Further studies revealed that the incidence was high in patients with mal
Sperm antigenicity is demonstrated by the formation of sperm antibodies following vasectomy and by the possible occurrence of hypersensitivity reactions in women to seminal fluid. It may be that immunosuppressor factors in seminal plasma, as well as certain placental hormones, could explain the fact that sperm are not
Specific antibody production was assessed in six young children with the acquired immune deficiency syndrome (AIDS). All patients were immunized with bacteriophage phi X 174, a T cell-dependent neoantigen. In addition, antibody responses to pneumococcal vaccine and tetanus toxoid, lymphocyte responses to mitogens, and
The authors report 3 cases of AIDS in children 10 and 11 years of age. These cases fulfill the definition of AIDS such as established by C.D.C. (Centers for Disease Control, Atlanta, Georgia U.S.A.) As opportunistic infections, the first case had oral moniliasis, the second case presented with ganglionic form of Kapos
Two cases of soft-tissue infection resulting from antibiotic therapy given AIDS patients are presented. Operative treatment resulted in a closed wound in one patient. In the other patient, who suffered from recurrent acute illnesses, nonoperative treatment resulted in slow wound contraction and epithelialization witho
Hulnick DH; Megibow AJ; Naidich DP; Hilton S; Cho KC; Balthazar EJ
The computed tomography (CT) scans of 27 patients with abdominal tuberculosis were reviewed retrospectively to determine the range of abdominal involvement. Most patients had been at increased risk because of intravenous drug abuse, alcoholism, acquired immunodeficiency syndrome (AIDS), cirrhosis, or steroid therapy.
S Afr Med J. 1985 Aug 31;68(5):327-30. Unique Identifier : AIDSLINE MED/85300886
Isaacs G; Miller D
The concerns of people affected by the current AIDS scare are discussed from a holistic point of view, incorporating medical, psychological and social factors. Parameters of homosexual experience are described fully. The medical practitioner is encouraged to obtain an extensive psychosexual history from concerned pa
S Afr Med J. 1985 Aug 31;68(5):330-1. Unique Identifier : AIDSLINE MED/85300887
Winters Z; Mannell A
A case of Kaposi s sarcoma of the oral cavity in a 54-year-old black man is reported. The possible association with acquired immune deficiency syndrome is emphasized and the diagnosis, treatment and prognosis of oral Kaposi s sarcoma are discussed.
Castella A; Croxson TS; Mildvan D; Witt DH; Zalusky R
During one year, 55 bone marrow biopsies from 49 patients with CDC-defined acquired immune deficiency syndrome (AIDS) were studied. Eighty-three percent were normocellular or hypercellular; 17% were hypocellular. Marrow plasma cells were increased in 83% of patients, most showing polyclonal hypergammaglobulinemia. For
Am J Gastroenterol. 1985 Sep;80(9):734-7. Unique Identifier : AIDSLINE MED/85304144
Bier SJ; Keller RJ; Krivisky BA; Liftin AJ
A previously unreported manifestation of esophageal moniliasis is described. Two patients with acquired immunodeficiency syndrome and Kaposi s sarcoma presented with solitary esophageal ulcers. Endoscopic biopsy confirmed the clinical diagnosis of esophageal moniliasis. The clinical and radiographic features of esopha
The use of chronic transfusions in patients with sickle cell disease is now the common practice after a stroke has occurred, in order to prevent the highly probable recurrence. Clinical studies show that chronic transfusion prevents the recurrence of a stroke. Review of the natural history of sickle cell disease indic
Ann Otolaryngol Chir Cervicofac. 1985;102(5):299-303. Unique Identifier : AIDSLINE MED/85305309
Marche C; Diebold J; Gehanno P; Bouton C; Neguesse Y
Histopathologic appearances of lymph nodes during acquired immune deficiency syndrome (AIDS) and related conditions are analyzed, with emphasis on the diagnostic and prognostic value of cervical gland biopsy at the lymphadenopathic stage. Details are given of the characteristics of the follicular hyperplasia of the ly
Am J Gastroenterol. 1985 Oct;80(10):774-8. Unique Identifier : AIDSLINE MED/85304110
Dworkin B; Wormser GP; Rosenthal WS; Heier SK; Braunstein M; Weiss L; Jankowski R; Levy D; Weiselberg S
Patients with acquired immunodeficiency syndrome (AIDS) frequently have diarrhea and weight loss. We prospectively examined the upper and lower gastrointestinal tracts in 22 AIDS patients, although severe medical problems often precluded full evaluation. Ninety-six percent (21 of 22) lost weight, and 55% (12 of 22) ha
Newell GR; Mansell PW; Wilson MB; Lynch HK; Spitz MR; Hersh EM
Responses to a lifestyle questionnaire among 13 patients with Kaposi s sarcoma and 18 with an opportunistic infection were compared with those of 29 symptom-free referred individuals. Odds ratios (OR) with 95% confidence limits were calculated as an estimate of risk. Significantly elevated odds ratios (P less than 0.0
Gan To Kagaku Ryoho. 1985 Sep;12(9):1749-54. Unique Identifier : AIDSLINE MED/85305777
Hayasaka K; Ishihara K
Kaposi s sarcoma (KS) is a very rare disease in Japan . The description by Moritz kaposi in 1872 of a multiple idiopathic pigment sarcoma of the skin stressed the multifocal lesions of the disease and its vascular nature, and it was renamed multiple idiopathic hemorrhagic sarcoma. Fo
Can Med Assoc J. 1985 Sep 1;133(5):401-6. Unique Identifier : AIDSLINE MED/85281877
Adrien A; Desrosiers M; Frappier-Davignon L; Spitzer WO; Dupuy JM
To investigate the occurrence of acquired immune deficiency syndrome in Haitians, a health status questionnaire was administered and selected studies of immune status done in a randomly chosen sample of 189 healthy adult Haitians living in Montreal. The study group was comparable to a large sample of Haitians in Montr
Cancer Res. 1985 Oct;45(10):4871-5. Unique Identifier : AIDSLINE MED/85282211
Boni-Schnetzler M; Boni J; Franklin RM
Polyclonal activation of T-cells with concanavalin A has been used as an in vitro test system to study immunosuppression induced by the avian retrovirus MAV-2-O. The mitogenic responsiveness of peripheral blood lymphocytes from infected chickens was only weakly suppressed, that of spleen lymphocytes was highly suppres
Vogt M; Luthy R; Bircher A; Furger F; Lang W; Maurer R; Siegenthaler W
A man who, only in 1979 and on a few occasions, had homosexual contacts, transmitted AIDS virus HTLV-III in 1980 and 1981 to two previously healthy women who did not belong to any AIDS risk group. One of them now has an early form of AIDS, while the other died of AIDS in its full form and her child, born in 1983, has
Rosen MJ; Tow TW; Teirstein AS; Chuang MT; Marchevsky A; Bottone EJ
Forty eight patients with the acquired immunedeficiency syndrome (AIDS) presented to the Mount Sinai Hospital in New York with persistent cough and dyspnoea or an abnormal chest radiograph, or both. Thirty two (67%) were found to have Pneumocystis carinii pneumonia, either alone or in combination with another pathogen
Ann Intern Med. 1985 Oct;103(4):522-33. Unique Identifier : AIDSLINE MED/85305195
Young KR Jr; Rankin JA; Naegel GP; Paul ES; Reynolds HY
Several components of cellular and humoral immunity were examined in bronchoalveolar lavage fluid and blood of 15 patients with the acquired immunodeficiency syndrome, and the results were compared to data from 25 healthy controls (including 5 asymptomatic homosexual men). Compared with that of controls, bronchoalveol
For 8 months we have studied the performance of the laser flow cytometry system Spectrum III (Ortho Diagnostic Systems). We have investigated problems caused by the setting and the calibration, assessment of the rhythm, the repetitiveness and the contamination, and compared the results obtained with the Spectrum III w
Clumeck N; Cran S; Van de Perre P; Mascart-Lemone F; Duchateau J; Bolla K
Three pilot studies testing thymopentin in AIDS patients are presented. One study included 5 patients with the full-blown syndrome, all treated with 50 mg thymopentin 3 times a week by intravenous slow infusion; no immunologically nor clinically positive results were observed, indicating that the T cell pool in such p
Am J Pathol. 1985 Sep;120(3):371-9. Unique Identifier : AIDSLINE MED/85304376
Wood GS; Burns BF; Dorfman RF; Warnke RA
The authors employed a panel of monoclonal antibodies to characterize B cells, histiocytes, and natural killer cells in lymph node biopsies obtained from 7 homosexual men with the acquired immune deficiency syndrome (AIDS) and 5 heterosexual controls. Six of the AIDS patients, each with cutaneous and/or nodal Kaposi s
Ann Intern Med. 1985 Oct;103(4):533-8. Unique Identifier : AIDSLINE MED/85305196
Kovacs JA; Kovacs AA; Polis M; Wright WC; Gill VJ; Tuazon CU; Gelmann EP; Lane HC; Longfield R; Overturf G; et al
The clinical course and response to therapy of 27 patients with cryptococcosis and the acquired immunodeficiency syndrome were reviewed. Cryptococcosis was the initial manifestation of the syndrome in 7 patients, and the initial opportunistic infection in an additional 7. Meningitis was the commonest clinical feature
Precautions used for dialysis patients who have acquired immunodeficiency syndrome or non-A, non-B hepatitis are based on infection control strategies developed for the control of hepatitis B in dialysis centers. Specifically, these recommendations include identifying infected patients; isolating (except for non-A, no
Murray HW; Gellene RA; Libby DM; Rothermel CD; Rubin BY
To test the hypothesis that tissue macrophages from AIDS patients have no intrinsic defects in either antimicrobial activity or in the capacity to respond to T cell-derived activating stimuli, alveolar macrophages from 11 patients were treated with crude lymphokines produced by healthy donors. After 72 hr of pretreatm
An epidemic form of Kaposi s sarcoma associated with the acquired immune deficiency syndrome has been recently described. Seven homosexual men with biopsy-documented epidemic Kaposi s sarcoma were treated with a human interferon-gamma preparation. All patients had generalized disease. Only one patient had received pri
Levin S; Hahn T; Handzel ZT; Galili-Wiesstub E; Bregman V; Myer R; Tinowitz M; Altman Y; Barzilai N; Brenner Y; et al
More than 50% of a group of healthy homosexuals in Israel were found to have an activated interferon (IFN) system as evidenced by markedly elevated blood IFN levels, increased in vitro production of IFN by unstimulated peripheral blood mononuclear cells and HuIFN-alpha and HuIFN-ga
Purified helper-inducer (T4+) and suppressor-cytotoxic (T8+) lymphocytes from eight patients with acquired immunodeficiency syndrome (AIDS) and eight healthy heterosexual donors were examined by limiting dilution analysis for their ability to be clonally expanded. It was demonstrated that viable T4+ and T8+ lymphocyte
Med Hypotheses. 1985 Jun;17(2):167-73. Unique Identifier : AIDSLINE MED/85295605
Mark AS; Mangkornkanok-Mark M
An immunologically oriented concept of the genesis of acquired immunodeficiency syndrome is presented in which the central event is the lack of cytotoxic T8 cells. An interlocking system wherein the T4 (helper) cells do not synthesize interleukin-2 to generate the cytotoxic cells due to the lack of functional thymosin
Natural antibody has been proposed as a mediator of T-independent (natural) resistance to tumors and microbial pathogens. In this article, it is argued that the priming of the B cell repertoire by ubiquitous microorganisms and autoantigens results in natural antibody production and this response offers a survival adva
Lawrence DN; Jason JM; Bouhasin JD; McDougal JS; Knutsen AP; Evatt BL; Joist JH
Thirty-four adult and pediatric hemophilia A and B patients and 50 nonhemophilic members belonging to 28 families were enrolled in August 1984 in a study of human T cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody status and T cell subpopulation numbers. All 50 household contac
Gjerset GF; McGrady G; Counts RB; Martin PJ; Jason J; Kennedy S; Evatt B; Hansen JA
Evidence for exposure to lymphadenopathy-associated virus (LAV) was investigated in 48 patients with hemophilia, 15 of whom had been treated exclusively with single-donor cryoprecipitate. The prevalence of antibodies to LAV in all patients was 53% in 1983 and 63% in 1984, while in patients treated only with cryoprecip
Groopman JE; Hartzband PI; Shulman L; Salahuddin SZ; Sarngadharan MG; McLane MF; Essex M; Gallo R
The human T-lymphotropic virus type III (HTLV-III) is the primary cause of the acquired immunodeficiency syndrome (AIDS) and related disorders (ARC). Prior studies have reported that nearly all symptomatic patients with AIDS or ARC manifest antibody to HTLV-III. This observation has engendered efforts to screen for HT
Hattori T; Robert-Guroff M; Chosa T; Matsuoka M; Yamaguchi K; Ishii T; Gallo RC; Takatsuki K
Seventy-one sera from Japanese individuals infected with human T cell leukemia virus type I (HTLV-I) were examined for the presence of antibodies to HTLV-III by an enzyme-linked immunosorbent assay (ELISA) and by a strip radioimmunoassay based on the Western blot technique. The sera were from 23 healthy carriers and f
Cancer. 1985 Oct 1;56(7):1688-90. Unique Identifier : AIDSLINE MED/85282036
Yamaguchi K; Yul LS; Shimizu T; Nozawa F; Takeya M; Takahashi K; Takatsuki K
Three sisters, ranging in age from 56 to 59 years, who developed lymphoma type adult T-cell leukemia (ATL) during a 19-month period are described. The patients were born in the Amakusa area of Kumamoto Prefecture, an area where the incidence of malignant lymphoma is high. The histologic diagnosis, made on the basis of
Cancer Lett. 1985 Aug;28(1):69-76. Unique Identifier : AIDSLINE MED/85282172
Renan MJ
Homologies in the control regions of 2 cellular oncogenes have been identified in this study. Both oncogenes (c-myc and c-fos) are known to be transiently induced by mitogens. We suggest that transcriptional activators bind to these putative control sequences, thus de-regulating gene expression in a coordinated and ce
Hybridization assays provide a sensitive and rapid means for studying the molecular biology of viral replication and for identifying viral nucleic acid in biological specimens. Such assays are attractive because the detection of virus does not require intact virions or concomitant viral protein synthesis, both of whic
Many patients with acquired immune deficiency syndrome (AIDS) and lymphadenopathy syndrome (LAS) have serum antilymphocyte antibodies. The targets of these antibodies are neither sex nor HLA directed. There is disagreement about the cell subset at risk. We examined the cellular specificity of antilymphocyte antibodies
EMBO J. 1985 Jun;4(6):1455-60. Unique Identifier : AIDSLINE MED/85284933
Kalyanaraman VS; Narayanan R; Feorino P; Ramsey RB; Palmer EL; Chorba T; McDougal S; Getchell JP; Holloway B; Harrison AK; et al
Human T cell leukemia virus (HTLV) type I has been isolated from the cultured T cells of several patients with adult T cell leukemia (ATL) and has been etiologically linked to ATL. However, HTLV-type II has been isolated only once, from the T cells of a patient with a T cell variant of hairy-cell leukemia. We report h
EMBO J. 1985 Jul;4(7):1783-92. Unique Identifier : AIDSLINE MED/85284969
Robbins KC; Leal F; Pierce JH; Aaronson SA
The v-sis transforming gene encodes the woolly monkey homologue of human platelet-derived growth factor (PDGF) polypeptide 2. After its synthesis on membrane bound polyribosomes, the glycosylated precursor dimerizes in the endoplasmic reticulum and travels through the Golgi apparatus. At the cell periphery, the precur
Immunol Lett. 1985;10(2):71-9. Unique Identifier : AIDSLINE MED/85287360
Zav'yalov VP; Denesyuk AI
Estimation of a content of secondary structures from amino acid composition of IL-2 (TCGF), PDGF and transforming protein p28sis of simian sarcoma virus by means of the previously suggested nomograms (V.P. Zav yalov and A.I. Denesyuk (1982) Immunol. Lett. 4, 7-14) allo
Kuo TT; Chan HL; Su IJ; Eimoto T; Maeda Y; Kikuchi M; Chen MJ; Kuan YZ; Chen WJ; Sun CF; et al
A serological survey of antibodies to the adult T-cell leukemia virus-associated antigen (HTLV-A) conducted in Taiwan revealed II seropositive individuals among 2,565 serum donors tested, which included 1,187 hospital or free clinic
Gazzolo L; Robert-Guroff M; Jennings A; Duc Dodon M; Najberg G; Peti MM; de-The G
Sera from 182 Zairians (99 females and 83 males), aged 5 to 71 years, including maternity and child care consultants, out-patients suffering from minor injuries and patients hospitalized for tuberculosis, malaria or trauma, were analyzed for specific antibodies to HTLV-I and HTLV-III. Following pre-screening by the EL
Uchiyama T; Hori T; Tsudo M; Wano Y; Umadome H; Tamori S; Yodoi J; Maeda M; Sawami H; Uchino H
We studied the expression of the interleukin-2 ( IL-2 ) receptor and the proliferative response to exogenous IL-2 of peripheral blood leukemic cells from patients with adult T cell leukemia (ATL) in order to see whether IL-2 receptor expressed on ATL cells is different f
McDougal JS; Martin LS; Cort SP; Mozen M; Heldebrant CM; Evatt BL
The virus that causes the acquired immunodeficiency syndrome (AIDS), human T lymphotropic virus/lymphadenopathy-associated virus (HTLV-III/LAV), was incubated at temperatures from 37 degrees to 60 degrees C and virus titer (ID-50) was determined over time by a microculture infectivity assay. The rate of thermal decay
An indirect immunofluorescence method was developed for the assay of antibodies to lymphadenopathy-associated virus (LAV) which is known to be associated with the aetiology of the acquired immunodeficiency syndrome (AIDS). Samples of serum or plasma from 1353 healthy volunteer blood donors, 53 homosexual males, 29 pat
Preble OT; Rook AH; Steis R; Silverman RH; Krause D; Quinnan GV; Masur H; Jacob J; Longo D; Gelmann EP
Titers of circulating interferon (IFN) and the activity of 2 -5 oligoadenylate (2-5A) synthetase, an enzyme specifically induced by IFN, were measured in 28 homosexual men with acquired immunodeficiency syndrome (AIDS) who received one- to six-month courses of antineoplastic therapy with IFN-alpha and in homosexual a
Read SE; Williams BR; Coates RA; Evans WK; Fanning MM; Garvey MB; Shepherd FA
The levels of the 2 -5 oligoadenylate enzyme synthetase in extracts of peripheral blood mononuclear cells from individuals with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) were measured and compared with synthetase levels in peripheral blood mononuclear cells (PBMs) from healthy heterosex
Bienzle U; Guggenmoos-Holzmann I; Zwingenberger K; Thommsen R; Ritter K; Uy A; Bayer H; Schneider J; Hunsmann G; Coester CH; et al
The study provides information on the epidemiology of HTLV-III infection and the lymphadenopathy syndrome (LAP) in 374 German homosexual men. Sexual contacts in the USA and rectal enemas before receptive anal intercourse are the main risk factors associated with virus transmission. HTLV-III seropositivity is significa
Twelve homosexual men had peripheral neuropathy with fever, night sweats, and lymphadenopathy. Sensory symptoms predominated, but there was also weakness and cranial nerve dysfunction. Manifestations were multifocal in nine and distal and symmetric in three. CSF was a
Minerva Med. 1985 Aug 25;76(32-33):1487-96. Unique Identifier : AIDSLINE MED/85296902
Papadia S; Grassi G; Zampetti A; Clementi F
Some toxic and infectious factors affecting pregnant drug addicts are analysed. Harmful effects on the foetus and the newborn are assessed. The problem of perinatal mortality as a result of maternal drug addiction is examined. A review of the literature reveals the mortality rate to be high.
Blood transfusion therapy confers an immunosuppressive effect on organ transplant recipients. The nonspecific immunosuppressive effect of third-party transfusions is useful for CAD transplantation, while donor transfusions improve the outcome of LRD grafts. Although there is evidence that erythrocytes, modified lympho
The biotechnology industry is thriving, and many predicted accomplishments have actually occurred during the last decade. Cloning and expression of genetic information is now simple and routine. Initial commercial products have been realized, but there is much yet to be accomplished in evaluating the clinical signific
Cytomegalovirus ( CMV ) causes serious illness in immunocompromised patients and congenitally infected neonates. Knowledge of the epidemiologic characteristics of CMV remains limited, but specific and practical measures can help prevent the transmission of infecti
49 french haemophiliacs (haemophilia A: 41 patients; haemophilia B: 8 patients) were serologicaly tested for LAV antibodies: 10 patients (20.4%) were seropositive including 9 (21.9%) with haemophilia A and 1 (12,5%) with haemophilia B. Between seronegative and seropositive patients total lymphocyte and T-lymphocyte su
Schupbach J; Vogt M; Bhushan R; Luthy R; Haller O; Joller H; Ferber T; Buchner S; Schuppli R; Schadelin J; et al
Acquired immune deficiency syndrome (AIDS) has been etiologically linked with the human T-cell lymphotropic virus HTLV-III. In a study on the prevalence of antibodies to this virus in Switzerland , sera from 941 individuals were collected in 5 major urban areas (Basel, Berne, G
Schweiz Med Wochenschr. 1985 Aug 17;115(33):1114-9. Unique Identifier : AIDSLINE MED/85300451
Joller-Jemelka HI; Wilhelm U; Steffen R; Grob PJ
In 1984 intravenous drug users accounted for 25% of all cases of acute hepatitis B and for 32% of all cases of non-A/non-B hepatitis recorded in the Canton of Zurich. Drug addicts also represented an important risk group for hepatitis A, which occurred in small epidemics. Among 141 healthy drug users, 10 (7%) individu
The reported incidence of acquired immune deficiency syndrome (AIDS) continues to increase in countries throughout the world. On the basis of a polynomial model for extrapolation, the cumulative number of cases diagnosed and reported since 1981 in the United States is expected to doubl
Rabson AB; Daugherty DF; Venkatesan S; Boulukos KE; Benn SI; Folks TM; Feorino P; Martin MA
The retrovirus frequently isolated from patients with the acquired immune deficiency syndrome (AIDS) has two novel open reading frames previously designated A and B. The A region was found to be specifically expressed as polyadenylated RNA s of 5.5 and 5.0 kilobases in infected cells. The B region was expressed as 1.8
Hoxie JA; Haggarty BS; Rackowski JL; Pillsbury N; Levy JA
Infection of normal peripheral blood T cells by the acquired immune deficiency syndrome (AIDS)-associated retrovirus (ARV) was evaluated in long-term cultures of helper-inducer T cells (T4 cells). Cells that were inoculated with ARV and maintained in medium supplemented with interleukin-2 remained productively infecte
Radiolabeled amino acid sequencing was used to characterize gp41, an antigen of HTLV-III/LAV, the virus believed to be the etiological agent of the acquired immune deficiency syndrome. This antigen is the one most commonly detected in immunoblot assays by sera of patients with AIDS or AIDS-related complex (ARC) and ot
Science. 1985 Oct 4;230(4721):71-3. Unique Identifier : AIDSLINE MED/85300530
Letvin NL; Daniel MD; Sehgal PK; Desrosiers RC; Hunt RD; Waldron LM; MacKey JJ; Schmidt DK; Chalifoux LV; King NW
The T-cell tropic retrovirus of macaque monkeys STLV-III has morphologic, growth, and antigenic properties indicating that it is related to HTLV-III/LAV, the etiologic agent of the acquired immune deficiency syndrome (AIDS) in humans. Four of six rhesus monkeys died within 160 days of STLV-III inoculation with a wasti
49 French haemophiliacs (haemophilia A: 41 patients; haemophilia B: 8 patients) were serologically testes for lymphadenopathy-AIDS virus antibodies: 10 patients (20.4%) were seropositive including 9 (21.9%) with haemophilia A and 1 (12.5%) with haemophilia B. Among haemophiliacs A, seropositive patients received signi
The newly identified human HTLV-III virus, the etiologic agent for AIDS, shares many of the biological and physicochemical properties common to a family of retroviruses named human T-cell leukemia (lymphotropic) viruses, or HTLV. Because of the similarities, and because of the uniform nomenclature for human T-cell leu
We have reviewed the biologic characteristics, immune responses, and diverse array of diseases occurring from Epstein-Barr virus infections in immune deficient patients. We have summarized possible roles of the virus in the risk groups for AIDS. Data is convincing that EBV is responsible for some of the cases of lymph
Peripheral blood lymphocyte subpopulations (PBLS) and HLA-DR phenotype have been evaluated in 30 IV drug users who were not affected by acquired immune deficiency syndrome (AIDS). A strongly significant reduction in helper/suppressor ratio was found in these subjects as compared to the control population. When the gro
This case report describes a case of chronic Epstein-Barr virus infection resulting in lymphadenopathy morphologically indistinguishable from Hodgkin s disease. Morphologic, immunologic, and virologic studies could be performed on three consecutive lymph nodes. For the first time in the literature, Epstein-Barr Nuclea
A 3-year-old girl, born to an intravenous-drug-dependent mother, had protracted diarrhea, failure to thrive, generalized lymphadenopathy, and recurrent fevers during the first six months of life. At 7 months of age, the Epstein-Barr virus (EBV) genome was detected in her saliva by DNA dot-blot hybridization using a cl
Am J Hematol. 1985 Oct;20(2):129-37. Unique Identifier : AIDSLINE MED/85304149
Jason JM; McDougal JS; Cabradilla C; Kalyanaraman VS; Evatt BL
Human T-cell leukemia virus (HTLV-I) is known to be associated with certain hematologic malignancies, and a related virus, HTLV-III/LAV, might be the cause of AIDS. Some persons with AIDS have had evidence of HTLV-I infection. Unrelated to these findings, it has been suggested that HTLV-I is transmitted via blood prod
Ann Intern Med. 1985 Oct;103(4):542-5. Unique Identifier : AIDSLINE MED/85305198
Walsh C; Krigel R; Lennette E; Karpatkin S
Thirty-three homosexual patients with thrombocytopenia (mean [+/- SE] platelet count, 50 000 +/- 7000/mm3; range, 7 to 135 000/mm3) have been followed for a mean period of 20 +/- 2 months. Six patients have developed the acquired immunodeficiency syndrome 1 to 37 months after the diagnosis of thrombocytopenia. Six pat
We present evidence of transmission of lymphadenopathy-associated virus (LAV)/human T-lymphotropic virus type III (HTLV-III) from a man to his wife, and a return to a normal number of T-helper lymphocytes and loss of antibody after discontinuing sexual exposure to LAV/HTLV-III. The man had hemophilia A, and developed
Ann Clin Res. 1985;17(2):81-5. Unique Identifier : AIDSLINE MED/85305424
Antonen J
In order to evaluate the immunological findings associated with HTLV-III virus infection, T-lymphocyte subpopulations and lymphocyte stimulation responses were studied in a voluntary group of 174 homosexual men living in Finland . An
Ann Neurol. 1985 Jul;18(1):74-9. Unique Identifier : AIDSLINE MED/85305581
Tucker T; Dix RD; Katzen C; Davis RL; Schmidley JW
Progressive ascending myelitis was the presenting feature of the acquired immune deficiency syndrome (AIDS) in a homosexual man who also had Kaposi s sarcoma, Pneumocystis pneumonia, and disseminated cytomegalovirus ( CMV ) inf
A Tac-positive B cell line termed K3B was established from a patient with adult T cell leukemia (ATL). This cell line had EBNA antigen and human T cell leukemic virus (HTLV) provirus besides B1 antigen and surface immunoglobulin. A cloned Tac-positive B cell line termed K3B01 was obtained from K3B by the limiting dilu
Lancet. 1985 Aug 24;2(8452):407-10. Unique Identifier : AIDSLINE MED/85294816
Gessain A; Barin F; Vernant JC; Gout O; Maurs L; Calender A; de The G
10 out of 17 (59%) patients with tropical spastic paraparesis (TSP) had antibodies to human T-lymphotropic virus-I (HTLV-I), as did 5 out of 5 TSP patients with systemic symptoms. Only 13 out of 303 (4%) controls, made up of blood donors, medical personnel, and other neurological patients, had such antibodies. These f
Biggar RJ; Gigase PL; Melbye M; Kestens L; Sarin PS; Bodner AJ; Demedts P; Stevens WJ; Paluku L; Delacollette C; et al
A serological survey of 250 outpatients in rural Zaire showed that the prevalence of antibody against HTLV-I, HTLV-II, and HTLV-III, as detected by enzyme-linked immunosorbent assay, correlated strongly with level of antibodies against Plasmodium falciparum. The age curve for the
Van de Perre P; Clumeck N; Carael M; Nzabihimana E; Robert-Guroff M; De Mol P; Freyens P; Butzler JP; Gallo RC; Kanyamupira JB
In July, 1984 33 female prostitutes in Rwanda and 25 male customers of prostitutes were assessed clinically and for their T-lymphocyte subsets and frequency of antibodies to human T-cell lymphotropic virus type III (HTLV-III). 27 healthy males who denied contact with prostitutes, 3
Human T-lymphotropic virus type III (HTLV-III) was isolated from the tears of 1 out of 7 patients with the acquired immunodeficiency syndrome (AIDS) or the AIDS-related complex. The tears from 5 healthy individuals did not show HTLV-III. The recovery of HTLV-III from tears suggests that they may harbour free virus or
The outbreak of the acquired immunodeficiency syndrome in the UK has great implications for health services, and predictions of future numbers of cases have been requested. There is not enough information to make a good estimate of the future epidemic curve, but the trend in new cases can be extrapolated and leads to
Four of eight recipients of artificial insemination (AI) with cryopreserved semen from a symptomless carrier of human T-cell lymphotropic virus type III (HTLV-III) were found to have antibody to the virus. One has generalised, persistent lymphadenopathy while the other three remain symptom free 3 years after inseminat
Levy JA; Shimabukuro J; Hollander H; Mills J; Kaminsky L
Acquired-immunodeficiency-syndrome (AIDS)-associated retroviruses (ARV) have been isolated from the cerebrospinal fluid and brain of homosexual men presenting with neurological symptoms. Most of these patients also met the clinical criteria for AIDS. The viruses grew readily in peripheral mononuclear cells and were id
Broder S; Yarchoan R; Collins JM; Lane HC; Markham PD; Klecker RW; Redfield RR; Mitsuya H; Hoth DF; Gelmann E; et al
Suramin was given to ten outpatients with acquired immunodeficiency syndrome (AIDS) presenting as Kaposi s sarcoma (KS) or as an AIDS-related complex (ARC). Side-effects associated with the administration of 6.2 g of suramin over 5 weeks included fevers, rashes, urinary abnormalities, and transient rises in hepatic am
Sixteen Italian patients with chronic T-cell lymphocytic leukaemia (T-CLL) and leukaemic T-helper phenotype lymphocytes (Thp-CLL) were investigated for serum antibodies against human T-cell leukaemia virus I (HTLV-I) or its integrated DNA sequences. Common features of this series of patients were an aggressive clinica
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