KAPOSI'S SARCOMA IN RENAL TRANSPLANT PATIENTS NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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KAPOSI'S SARCOMA IN RENAL TRANSPLANT PATIENTS

AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 41-4, 1984.. Unique Identifier : AIDSLINE ICDB/85610687
Harwood AR; The Princess Margaret Hosp., Toronto, Ontario, Canada M4X 1K9

Abstract: Clinical aspects of the Kaposi's sarcoma (KS) that is associated with renal transplant (RT) are reviewed. KS is reported in approx 0.4% of RT recipients, an incidence 150-200 times that of the general population. To date, 23 cases have been reported in detail; the mean age was 42, the male:female ratio was 1.6:1, the predominant ethnic ancestry was Jewish, Mediterranean, or African, and the mean interval between RT and KS was 16 mo. Twenty-two patients (pts) received Imuran and steroids. Seven pts died of the KS; 4 died of renal failure and related causes; 2 are alive and well but without renal function; and 10 are alive and well with renal function and with KS in remission. Degree of immunosuppression was correlated with the KS. After immunosuppressive Imuran therapy for the RT was discontinued, complete remission with renal preservation was observed in 5 cases, complete remission without renal preservation in 2, and no response in 4. Radiotherapy was given in 15 cases and was successful for local control in 13. The author concludes that KS associated with RT is similar to the KS of the Acquired Immune Deficiency Syndrome or the KS of tropical Africa. He proposes that pts should receive full evaluation to exclude generalized disease, that localized disease should be treated with radiotherapy, and that generalized disease should be treated with chemotherapy and discontinuation of Imuran. (21 Refs)
Keywords: Adult Aged Canada Female Human Immunity, Cellular Kidney/*TRANSPLANTATION *Kidney Transplantation Male Postoperative Complications Sarcoma, Kaposi's/*EPIDEMIOLOGY/IMMUNOLOGY/THERAPY MEETING PAPER REVIEW

KWDadultagedcanadafemalehumanimmunity,cellularkidney/KWDtransplantationKWDkidneytransplantationmalepostoperativecomplicationssarcoma,kaposi's/KWDepidemiology/immunology/therapymeetingpaperreview
850830
M8580188

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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