LYMPHOCYTE EFFECTOR FUNCTION IN VITRO IN THE ACQUIRED IMMUNE DEFICIENCY SYNDROME

Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

LYMPHOCYTE EFFECTOR FUNCTION IN VITRO IN THE ACQUIRED IMMUNE DEFICIENCY SYNDROME

AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 153-9, 1984.. Unique Identifier : AIDSLINE ICDB/85610700
Cunningham-Rundles S; Safai B; Metroka C; Krown SE; Rubin BY; Stahl WM; Sloan-Kettering Inst., Clinical Cellular Immunology Lab.,; Memorial Sloan-Kettering Cancer Center, New York, NY 10021

Abstract: Results of experiments assessing in vitro T-cell functions in patients (pts) with the Acquired Immune Deficiency Syndrome (AIDS) are reported. Natural killer (NK) activity was assayed, both with and without interferon augmentation, by measuring lysis of K562 target cells. Pts with opportunistic infections had poorer endogenous NK activity than pts presenting with Kaposi's sarcoma (KS). NK activity inducible by interferon was absent in about 40% of AIDS-KS pts and in more than three-fourths of lymphadenopathic pts. Spontaneous return of inducible NK activity was observed in follow-up of three pts with the lymphadenopathy. The proliferative response to phytohemagglutinin was lower in AIDS lymphocytes than in normal control lymphocytes, while inhibition by concanavalin A-amplified suppressor cells ranged from 8.7 to 69.3% in the AIDS group and from 27.3 to 50.2% in the control group. When lymphocytes of three AIDS pts were assayed in an autologous mixed lymphocyte culture reaction, the response was normal for one patient, reduced for one and complex for one. Analysis of supernatants from the mixed cultures indicated a correlation between cytotoxicity and the generation of interferon. The authors conclude that NK activity is more frequently normal for the AIDS-KS subgroup of pts than for others AIDS subgroups and that suppressor cell function may be enhanced in AIDS. (14 Refs)

Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adult *Cytotoxicity, Immunologic Human Infection/COMPLICATIONS Interferon Type I/*PHARMACOLOGY Killer Cells, Natural/*IMMUNOLOGY Lymphatic Diseases/IMMUNOLOGY Lymphocyte Culture Test, Mixed Lymphocyte Transformation Male Sarcoma, Kaposi's/COMPLICATIONS T-Lymphocytes/IMMUNOLOGY T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY MEETING PAPER

850830
M8580179

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1985. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .