THE RELATIONSHIP OF CYTOMEGALOVIRUS TO KAPOSI'S SARCOMA NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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THE RELATIONSHIP OF CYTOMEGALOVIRUS TO KAPOSI'S SARCOMA

AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 329-36, 1984.. Unique Identifier : AIDSLINE ICDB/85610706
Fenoglio CM; McDougall JK; Albuquerque VA Medical Center, Albuquerque, NM 87107

Abstract: Tumor cells from a homosexual man with Kaposi's sarcoma (KS) and testicular carcinoma were studied for evidence of the presence of cytomegalovirus (CMV) nucleic acids. The patient (pt) was a 35-yr-old white Jewish male who underwent left radical orchiectomy for embryonal carcinoma of the testis; one retroperitoneal lymph node was positive for metastasis. The pt was treated with vinblastine, actinomycin D, bleomycin, and chlorambucil. After 2 yr, there was no evidence of recurrent carcinoma, but a rectal lesion was noted that was diagnosed by biopsy as KS. In the subsequent month, the pt developed skin and mucosal lesions and generalized lymphadenopathy. Sections of a skin nodule were studied by an in situ hybridization technique, using viral DNA probes for CMV and herpes simplex virus Type 2 (HSV-2). Staining of the tumor cells was positive for CMV but negative for HSV-2, while all normal tissues were negative for both viruses. The authors concluded that CMV was present in this sample of KS tumor tissue, and they speculate that CMV may be an etiologic factor in the Acquired Immune Deficiency Syndrome. (52 Refs)
Keywords: Adult Case Report Cytomegalovirus/*GENETICS DNA, Viral/ANALYSIS *Genes, Viral Human Male Nucleic Acid Hybridization RNA, Viral/ANALYSIS Sarcoma, Kaposi's/*MICROBIOLOGY/PATHOLOGY Skin Neoplasms/*MICROBIOLOGY/PATHOLOGY MEETING PAPER

KWDadultcasereportcytomegalovirus/KWDgeneticsdna,viral/analysisKWDgenes,viralhumanmalenucleicacidhybridizationrna,viral/analysissarcoma,kaposi's/KWDmicrobiology/pathologyskinneoplasms/KWDmicrobiology/pathologymeetingpaper
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Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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