THE SIGNIFICANCE OF INTERFERON IN SERUM OF PATIENTS WITH ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS) AND OF PERSONS AT RISK NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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THE SIGNIFICANCE OF INTERFERON IN SERUM OF PATIENTS WITH ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS) AND OF PERSONS AT RISK

The Role of Viruses in Human Cancer. Volume II. Giraldo G, Beth E, eds. New York, Elsevier Science Publishers, p. 195-200, 1984.. Unique Identifier : AIDSLINE ICDB/85610755
Buimovici-Klein E; Lange M; Klein RJ; Grieco MH; Cooper LZ; St. Luke's-Roosevelt Hosp. Center, Dept. of Pediatrics, New York,; NY 10019

Abstract: As tests for premonitory signs of risk of acquired immune deficiency syndrome (AIDS), serum levels of interferon-alpha (IFN) were measured in 25 AIDS patients (pts), 76 healthy homosexual males, and 24 healthy heterosexual males. The method of measurement involved treating trisomy 21 fibroblast cultures with serial dilutions of serum, then challenging the cells with encephalomyelitis virus. The IFN was detected in all of the AIDS pts, in 52 of the homosexual controls and in 1 of the heterosexual controls. The mean IFN titer was 4 units for healthy heterosexuals, 31 for healthy homosexuals, 123 for pts with AIDS and opportunistic infection, and 262 for pts with AIDS and Kaposi's sarcoma. Five healthy homosexual controls who had the highest IFN titers all developed AIDS within 17 mo. The authors conclude that IFN is associated with AIDS and that high IFN titers in homosexuals at risk may predict the development of AIDS. IFN is hypothesized to be a product induced by the AIDS agent, or a consequence of autoimmune phenomena. (8 Refs)
Keywords: Acquired Immunodeficiency Syndrome/DIAGNOSIS/*IMMUNOLOGY Hemophilia/BLOOD Homosexuality Human Interferon Type I/BLOOD Interferon Type II/BLOOD Interferons/BLOOD Male Pneumonia, Pneumocystis carinii/BLOOD Risk Sarcoma, Kaposi's/BLOOD MEETING PAPER

KWDacquiredimmunodeficiencysyndrome/diagnosis/KWDimmunologyhemophilia/bloodhomosexualityhumaninterferontypei/bloodinterferontypeii/bloodinterferons/bloodmalepneumonia,pneumocystiscarinii/bloodrisksarcoma,kaposi's/bloodmeetingpaper
850830
M8580172

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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