ADULT T-CELL LEUKEMIA VIRUS (ATLV): AN OUTLOOK NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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ADULT T-CELL LEUKEMIA VIRUS (ATLV): AN OUTLOOK

The Role of Viruses in Human Cancer. Volume II. Giraldo G, Beth E, eds. New York, Elsevier Science Publishers, p. 331-43, 1984.. Unique Identifier : AIDSLINE ICDB/85610765
Hinuma Y; Inst. for Virus Res., Kyoto Univ., Kyoto 606 (Japan)

Abstract: Adult T-cell leukemia (ATL) is a new disease entity that is endemic in southwest Japan. A retrovirus, ATL virus (ATLV), has been isolated from ATL-related cell lines and detected in fresh ATL cells. The DNAs of leukemic cells from all ATL patients (pts) tested were shown to contain integrated ATLV sequences, and virus particles have been seen budding from cultured cells. Normal lymphocytes can be transformed by ATLV only when it is associated with cells. Lymphocytes other than T-cells appear to be susceptible to infection. Ten proteins associated with ATLV have been detected and characterized. Antibodies to ATLV have been identified in infected pts and in some healthy persons who may be carriers. Leukemic T-cells in ATL contain the OKT-4 marker, but most ATL pts have impaired cellular immunity. Transmission is horizontal and has been documented to occur by blood transfusion. ATLV may be similar to human T-cell leukemia virus, although no evidence has associated ATLV with the Acquired Immune Deficiency Syndrome. (41 Refs)
Keywords: Adult Antibodies, Viral/ANALYSIS B-Lymphocytes/MICROBIOLOGY Cell Transformation, Neoplastic/ULTRASTRUCTURE Cell Transformation, Viral DNA, Viral/ANALYSIS Human HTLV-BLV Viruses/IMMUNOLOGY/PATHOGENICITY Inclusion Bodies, Viral/ULTRASTRUCTURE Leukemia/IMMUNOLOGY/*MICROBIOLOGY Microscopy, Electron Retroviridae Infections/IMMUNOLOGY/*MICROBIOLOGY T-Lymphocytes/MICROBIOLOGY Virulence Virus Replication MEETING PAPER


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Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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