VIRUSES IN HUMAN LEUKAEMIA NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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VIRUSES IN HUMAN LEUKAEMIA

The Role of Viruses in Human Cancer. Volume II. Giraldo G, Beth E, eds. New York, Elsevier Science Publishers, p. 345-63, 1984.. Unique Identifier : AIDSLINE ICDB/85610766
Karpas A; Dept. of Hematological Medicine, Cambridge Univ. Medical Sch.,; Hills Road, Cambridge, UK

Abstract: Adult T-cell leukemia (ATL) is an endemic malignancy of southwest Japan which has been closely associated with a retrovirus, ATLV, in serologic, epidemiologic, virological, and molecular studies. All criteria for a causal relationship have been met. Mycosis fungoides (MF) and the Sezary syndrome (SS) are T-cell lymphomas in which isolation of the human T-cell leukemia virus (HTLV) has been reported, but serologic, virological, and molecular studies have been inconsistent. Adult T-cell leukemia/lymphoma (ATLL) is a malignancy of helper T-cells; it resembles Japanese ATL but occurs in blacks. In a study of fresh leukemic cells from children with acute lymphoid leukemia, inclusion bodies containing virus-like particles (VLP) were observed in 12 of 28 patients, and VLP were also expressed in leukemic cell lines. The author concludes that ATLV is a causative agent of ATL; that ATLV is not associated with MF or SS; that reports associating HTLV with MF or SS probably misdiagnosed these diseases for ATLL; that ATLV and HTLV are related but not identical; and that VLP may represent the expression of viral structural proteins. (76 Refs)
Keywords: Adult Animal Antibodies, Viral/ANALYSIS Antigens, Viral, Tumor/IMMUNOLOGY Base Sequence Burkitt's Lymphoma/MICROBIOLOGY DNA, Viral/ANALYSIS Herpesvirus 4, Human/IMMUNOLOGY/PATHOGENICITY Human HTLV-BLV Viruses/IMMUNOLOGY/PATHOGENICITY Inclusion Bodies, Viral Leukemia/IMMUNOLOGY/*MICROBIOLOGY Mycosis Fungoides/MICROBIOLOGY Retroviridae Infections/IMMUNOLOGY/*MICROBIOLOGY Sezary Syndrome/MICROBIOLOGY Tumor Virus Infections/IMMUNOLOGY/*MICROBIOLOGY Virulence MEETING PAPER REVIEW


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Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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