Pediatric acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Pediatric acquired immunodeficiency syndrome.

Ann N Y Acad Sci. 1984;437:340-9. Unique Identifier : AIDSLINE MED/85197370
Ammann AJ; Wara DW; Cowan MJ

Abstract: Approximately 40 to 50 infants and children with similar epidemiologic, clinical, and laboratory features of AIDS have been described. The occurrence of significant numbers of patients with PAIDS in geographic areas that are associated with similar risk factors and clinical features of AIDS suggests a common cause. Immunologic evaluation reveals hypergammaglobulinemia, decreased or absent antibody responses after immunization, normal to decreased T-cell numbers, decreased helper/suppressor cell ratios, and abnormal results of functional studies of T-cells. None of the patients described has the clinical or laboratory features of well-established congenital immunodeficiency disorders. No consistent viral agent has been documented except for antibody to ARV and HTLV III. The frequent finding of T-cell abnormalities in the mothers of infants with PAIDS is in contrast to the absence of such abnormalities in the mothers of infants with congenital immunodeficiency disorders. Future studies in PAIDS should be directed toward uncovering the etiology and risk factors as well as determining the response to treatment with various methods of immunologic reconstitution.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/*DIAGNOSIS/ IMMUNOLOGY/PHYSIOPATHOLOGY Child, Preschool Diagnosis, Differential Human Infant Infant, Newborn T-Lymphocytes/IMMUNOLOGY T-Lymphocytes, Helper-Inducer T-Lymphocytes, Suppressor-Effector Virus Diseases/COMPLICATIONS JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complications/KWDdiagnosis/immunology/physiopathologychild,preschooldiagnosis,differentialhumaninfantinfant,newbornt-lymphocytes/immunologyt-lymphocytes,helper-inducert-lymphocytes,suppressor-effectorvirusdiseases/complicationsjournalarticle
850830
M8580126

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1985. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .