Immunologic studies of the acquired immune deficiency syndrome: relationship of immunodeficiency to extent of disease. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Immunologic studies of the acquired immune deficiency syndrome: relationship of immunodeficiency to extent of disease.

Ann N Y Acad Sci. 1984;437:364-72. Unique Identifier : AIDSLINE MED/85197372
Hersh EM; Reuben JM; Mansell PW; Rios A; Gutterman JU; Munn G; Murray JL; Spector SP; Goldstein AL; Newell GR

Abstract: Immunologic and conventional laboratory studies were done in 135 previously untreated subjects including 28 (20.7%) symptom-free homosexuals and 74 (54.8%) with ARC and 33 (24.5%) with AIDS. More than half of all patients had abnormal percentages of lymphocytes, percentages of T3+ cells, percentage and absolute number of T4+ cells, percentage of T8+ cells, T4/T8 ratio, monocyte adherence, and serum thymosin alpha 1. Most immune variables worsened with progressive disease. Low lymphocyte 5'nucleotidase increased suppressor cell activity, and impaired IL-2 and alpha interferon production and response suggest diminished mature and increased immature peripheral blood and tissue T cells. These findings suggest approaches to staging, prognostication, and treatment for AIDS.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Analysis of Variance Antigens, Surface/IMMUNOLOGY Blood Cell Count Comparative Study *Homosexuality Human Interleukin-2 Killer Cells, Natural/IMMUNOLOGY Lymphocyte Transformation Male Nucleosidases/IMMUNOLOGY Skin Tests Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes, Helper-Inducer/IMMUNOLOGY T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyanalysisofvarianceantigens,surface/immunologybloodcellcountcomparativestudyKWDhomosexualityhumaninterleukin-2killercells,natural/immunologylymphocytetransformationmalenucleosidases/immunologyskintestssupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes,helper-inducer/immunologyt-lymphocytes,suppressor-effector/immunologyjournalarticle
850830
M8580125

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1985. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .