Soluble factors inhibitory for T-cell-dependent immune responses in patients with the acquired immune deficiency syndrome and its prodromes. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Soluble factors inhibitory for T-cell-dependent immune responses in patients with the acquired immune deficiency syndrome and its prodromes.

Ann N Y Acad Sci. 1984;437:518-25. Unique Identifier : AIDSLINE MED/85197395
Laurence J; Gottlieb AB; Kunkel HG

Abstract: Supernatants from PBMC obtained from certain patients with AIDS or its prodrome were capable of depressing pokeweed mitogen-driven immunoglobulin production and the proliferative response of T cells to specific antigen. These soluble suppressor factors (SSF) were present in uniquely high concentrations, and were the product of an interaction of T lymphocytes with adherent cells. T-cell independent functions were not modified by soluble suppressor factors. Restoration of immunoglobulin synthesis in SSF-treated cultures was realized by addition of reducing agents such as 2-mercaptoethanol, suggesting inhibitory mechanisms possibly related to that of Con A-induced soluble immune response suppression, and perhaps offering clues to clinically applicable substances capable of modifying such responses. A relationship between SSF-AIDS and a human retrovirus LAV/HTLV III, linked etiologically to AIDS and its prodromes, is suggested by studies of SSF-like substances released by human T-T cell hybridomas derived from LAV+ patients.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adult Cell Survival Cells, Cultured Female Homosexuality Human Interleukin-2/*IMMUNOLOGY Lymphoma/IMMUNOLOGY Male Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes, Helper-Inducer T-Lymphocytes, Suppressor-Effector/*IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyadultcellsurvivalcells,culturedfemalehomosexualityhumaninterleukin-2/KWDimmunologylymphoma/immunologymalesupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes,helper-inducert-lymphocytes,suppressor-effector/KWDimmunologyjournalarticle
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M8580121

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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