AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 1-351, 1984.. Unique Identifier : AIDSLINE ICDB/85610683
Anonymous; No affiliation given
This vol is based, in large part, on a symposium on the Acquired Immune Deficiency Syndrome (AIDS), held at the New York University Medical Center in March 1983. Principal topics include the epidemiology of AIDS and Kaposi s sarcoma (KS), clinical features of these diseases, immunologic abnormalities, possible etiolog
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 7-21, 1984.. Unique Identifier : AIDSLINE ICDB/85610684
Levine AS; National Inst. of Child Health and Human Development, NIH,; Bethesda, MD 20205
The roles of immunologic dysfunction and viral infections in the development of the Acquired Immune Deficiency Syndrome (AIDS) are discussed in this article. The weight of the evidence favors the hypothesis that a single transmissible viral agent causes the immune dysfunction of AIDS. This dysfunction is characterized
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 22-34, 1984.. Unique Identifier : AIDSLINE ICDB/85610685
Friedman-Kien AE; Ostreicher R; New York Univ. Medical Center New York, NY 10016
Epidemiologic and clinical aspects of Kaposi s sarcoma (KS) are reviewed, and the classic form of the disease is compared with the epidemic form. Classic KS is a rare, benign, indolent tumor of elderly white men who are of Eastern European Jewish or Italian origin, characterized by multifocal discolored nodules and oc
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 41-4, 1984.. Unique Identifier : AIDSLINE ICDB/85610687
Harwood AR; The Princess Margaret Hosp., Toronto, Ontario, Canada M4X 1K9
Clinical aspects of the Kaposi s sarcoma (KS) that is associated with renal transplant (RT) are reviewed. KS is reported in approx 0.4% of RT recipients, an incidence 150-200 times that of the general population. To date, 23 cases have been reported in detail; the mean age was 42, the male:female ratio was 1.6:1, the
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 51-5, 1984.. Unique Identifier : AIDSLINE ICDB/85610689
Laubenstein L; Div. of Hematology, Dept. of Medicine, New York Univ. Medical; Center, New York, NY 10016
Kaposi s sarcoma (KS) is classified as Stage I when cutaneous and locally indolent, Stage II when cutaneous and locally aggressive, Stage III when mucocutaneous or when lymph node involvement is generalized, and Stage IV when visceral. The disease is subtyped as A when systemic signs or symptoms are absent and as B wh
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 63-7, 1984.. Unique Identifier : AIDSLINE ICDB/85610691
Volberding P; Univ. of California at San Francisco, San Francisco, CA 94110
Ten patients (pts) with Kaposi s sarcoma (KS) in the Acquired Immune Deficiency Syndrome (AIDS) were randomized to undergo treatment with alpha-2-interferon (a-2-IF). Five pts received low-dose therapy, using 1,000,000 units/m2/day sc for 5 days on alternate wk for 2 mo; and five received high-dose therapy, using 50,0
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 69-72, 1984.. Unique Identifier : AIDSLINE ICDB/85610692
Krigel RL; Dept. of Hematology, New York Univ. Medical Center, New York, NY; 10016
In a study of 86 patients (pts) with epidemic Kaposi s sarcoma, the estimated probability of survival (EPS) at 28 mo was 45% for all pts, 80% for those without an opportunistic infection (OI), and 20% for those with OI. The EPS at 18 mo was 100% for Stage I, 86% for Stage IIIA, 75% for Stage IVA, 33% for Stage IIIB, 1
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 81-8, 1984.. Unique Identifier : AIDSLINE ICDB/85610694
Abrams DI; Cancer Res. Inst., Univ. of California at San Francisco, San; Francisco, CA 94110
In a study of the relation of lymphadenopathy to the Acquired Immune Deficiency Syndrome (AIDS), 70 homosexual or bisexual men from San Francisco were evaluated by history, physical examination, and laboratory studies. All patients (pts) had lymphadenopathy for at least 6 mo. Sixty pts were white, 6 were Hispanic, and
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 101-10, 1984.. Unique Identifier : AIDSLINE ICDB/85610695
Pagano JS; Cancer Res. Center, Univ. of North Carolina, Chapel Hill, NC; 27514
Evidence and hypotheses regarding viral etiologies of Kaposi s sarcoma (KS) and the Acquired Immune Deficiency Syndrome (AIDS) are discussed. Viruses implicated (with varying degrees of certainty) in human tumors include human T-cell leukemia viruses, papillomavirus, papova viruses, adenovirus, herpes simplex II,
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 111-26, 1984.. Unique Identifier : AIDSLINE ICDB/85610696
Huang ES; Dept. of Medicine, Cancer Res. Center, Univ. of North Carolina at; Chapel Hill, Chapel Hill, NC 27514
Cytomegalovirus ( CMV ) infection occurs at an extremely high frequency among Acquired Immune Deficiency Syndrome (AIDS) patients (pts) and has been hypothesized to be a cause or a result of the disease. Kaposi s sarcoma (KS) also frequently occurs in AIDS pts; th
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 127-133, 1984.. Unique Identifier : AIDSLINE ICDB/85610697
Two cases are reported in which a human T-cell leukemia virus (HTLV) was associated with the Acquired Immune Deficiency Syndrome (AIDS). It is noted that HTLV is tropic for human T-cells and is endemic in the West Indies. Because HTLV is a retrovirus, evidence of cell infection is elusive. The HTLV has been identified
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 147-52, 1984.. Unique Identifier : AIDSLINE ICDB/85610699
Lane HC; Fauci AS; Natl. Inst. of Allergy and Infectious Diseases, NIH, Bethesda, MD; 20205
The Acquired Immune Deficiency Syndrome (AIDS) constitutes a dysfunction of cellular immunity due to a selective depletion of T-helper cells; lymphopenia is the result primarily of this depletion. Impairment of T-cell function in vivo is demonstrated by anergy and by increased susceptibility to neoplasms and to opport
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 153-9, 1984.. Unique Identifier : AIDSLINE ICDB/85610700
Cunningham-Rundles S; Safai B; Metroka C; Krown SE; Rubin BY; Stahl WM; Sloan-Kettering Inst., Clinical Cellular Immunology Lab.,; Memorial Sloan-Kettering Cancer Center, New York, NY 10021
Results of experiments assessing in vitro T-cell functions in patients (pts) with the Acquired Immune Deficiency Syndrome (AIDS) are reported. Natural killer (NK) activity was assayed, both with and without interferon augmentation, by measuring lysis of K562 target cells. Pts with opportunistic infections had poorer e
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 161-8, 1984.. Unique Identifier : AIDSLINE ICDB/85610701
Zolla-Pazner S; Sidhu G; Dept. of Pathology, New York Univ. Medical Center, New York, NY; 10016
Hypotheses regarding B-cell hyperactivity in the Acquired Immune Deficiency Syndrome (AIDS) are discussed. B-cell hyperactivity in AIDS is suggested by an increased incidence of B-cell lymphomas; by polyclonal hypergammaglobulinemia in 90% of cases; by follicular hyperplasia; by effacement of follicular architecture i
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 199-205, 1984.. Unique Identifier : AIDSLINE ICDB/85610702
Welte K; Ciobanu N; Kruger G; Venuta S; Feldman SP; Sternberg C; Palladino MA; Koziner B; Gold J; Safai B; et al; Dept. of Hematology, Memorial Sloan-Kettering Cancer Center, New; York, NY 10021
To elucidate the decreased responsiveness to mitogen stimulation in patients (pts) with the Acquired Immune Deficiency Syndrome (AIDS), peripheral blood lymphocytes (PBLs) from 21 homosexual males were studied for response to OKT3 antibody and to phytohemagglutinin (PHA); for production of interleukin-2 (
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 235-9, 1984.. Unique Identifier : AIDSLINE ICDB/85610703
Horowitz L; Stern JO; Segarra S; New York Univ. Medical Center, New York, NY 10016
Visceral involvement occurs in 10% of patients (pts) with classic Kaposi s sarcoma (KS), and up to 66% of these have gastrointestinal (GI) involvement. Most GI involvement is asymptomatic, but mucosal ulceration, GI hemorrhage, obstruction, perforation, pain, diarrhea, and protein-losing enteropathy have been reported
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p.291-6, 1984.. Unique Identifier : AIDSLINE ICDB/85610705
Marmor M; Lab. of Bio-Statistics and Epidemiology, Inst. of Environmental; Medicine, New York Univ. Medical Center, New York, NY 10010
In a demographic analysis of risk factors for Kaposi s sarcoma (KS) among homosexual men, 20 of the first 21 men with biopsy-proven KS seen at the New York University Medical Center were compared with 40 age- and race-matched homosexual controls. The subjects were interviewed by questionnaire regarding sexual practice
AIDS. The Epidemic of Kaposi's Sarcoma and Opportunistic Infections. Friedman-Kien AE, Laubenstein LJ, eds. New York, Masson, p. 329-36, 1984.. Unique Identifier : AIDSLINE ICDB/85610706
Fenoglio CM; McDougall JK; Albuquerque VA Medical Center, Albuquerque, NM 87107
Tumor cells from a homosexual man with Kaposi s sarcoma (KS) and testicular carcinoma were studied for evidence of the presence of cytomegalovirus ( CMV ) nucleic acids. The patient (pt) was a 35-yr-old white Jewish male who un
The Role of Viruses in Human Cancer. Volume II. Giraldo G, Beth E, eds. New York, Elsevier Science Publishers, p. 119-36, 1984.. Unique Identifier : AIDSLINE ICDB/85610751
Purtilo DT; Dept. of Pathology, Univ. of Nebraska Medical Center, 42nd and; Dewey Ave., Omaha, NE 68105
Epstein-Barr virus (EBV) isolated from patients (pts) with infectious mononucleosis (IM), Burkitt s lymphoma (BL), or nasopharyngeal carcinoma appears to constitute one strain, implying that host immune response, cofactors, and cytogenetic events govern the outcome of infection. Host defense against EBV includes natur
The Role of Viruses in Human Cancer. Volume II. Giraldo G, Beth E, eds. New York, Elsevier Science Publishers, p. 195-200, 1984.. Unique Identifier : AIDSLINE ICDB/85610755
Buimovici-Klein E; Lange M; Klein RJ; Grieco MH; Cooper LZ; St. Luke's-Roosevelt Hosp. Center, Dept. of Pediatrics, New York,; NY 10019
As tests for premonitory signs of risk of acquired immune deficiency syndrome (AIDS), serum levels of interferon-alpha (IFN) were measured in 25 AIDS patients (pts), 76 healthy homosexual males, and 24 healthy heterosexual males. The method of measurement involved treating trisomy 21 fibroblast cultures with serial di
The Role of Viruses in Human Cancer. Volume II. Giraldo G, Beth E, eds. New York, Elsevier Science Publishers, p. 331-43, 1984.. Unique Identifier : AIDSLINE ICDB/85610765
Adult T-cell leukemia (ATL) is a new disease entity that is endemic in southwest Japan . A retrovirus, ATL virus (ATLV), has been isolated from ATL-related cell lines and detected in fresh ATL cells. The DNAs of leukemic cells from all ATL patients (pts) tested were shown to contain
The Role of Viruses in Human Cancer. Volume II. Giraldo G, Beth E, eds. New York, Elsevier Science Publishers, p. 345-63, 1984.. Unique Identifier : AIDSLINE ICDB/85610766
Karpas A; Dept. of Hematological Medicine, Cambridge Univ. Medical Sch.,; Hills Road, Cambridge, UK
Adult T-cell leukemia (ATL) is an endemic malignancy of southwest Japan which has been closely associated with a retrovirus, ATLV, in serologic, epidemiologic, virological, and molecular studies. All criteria for a causal relationship have been met. Mycosis fungoides (MF) and the Se
In this review, studies are summarized that have led to identification of the first normal cellular function of a proto-oncogene, and evidence is presented which suggests how this gene may be involved in certain kinds of human cancer. Also described are investigations of another family of proto-oncogenes that have bee
Ann N Y Acad Sci. 1984;437:493-502. Unique Identifier : AIDSLINE MED/85197391
Davis AE Jr
Histologic study of the thymus glands from patients who have died of AIDS reveals changes consistent with an organ-specific immune complex attack by polyclonal immunoglobulins directed against the thymic epithelial cells, Hassall s corpuscles, and certain subsets of thymocytes. This results in marked architectural alt
We have examined the numbers of the total T (T11+) cells, T-helper (T4+) cells, T-suppressor (T8+) cells, NK cells (Leu7+), and the functional integrity of T, B, and NK cells in healthy male heterosexuals and compared the data to those obtained from AIDS patients and male homosexuals at risk. The absolute number of to
Acquired immune deficiency syndrome (AIDS) is a newly described syndrome in which patients are susceptible to certain malignancies and opportunistic infections (OI) usually found only in immunosuppressed individuals. Patients with AIDS have been found to have deficiencies of virtually all of their host defense systems
Clumeck N; van de Perre P; Mascart-Lemone F; Cran S; Bolla K; Duchateau J
In an open study, 10 African patients with AIDS were treated with thymopentin 50 mg i.v. 3 times a week for 2 consecutive months: 1 month by i.v. direct injections and 1 month by 30-min i.v. infusions. In group A there were 6 patients with AIDS-lymphadenopathy characterized by weight loss, chronic fever, generalized l
Ann N Y Acad Sci. 1984;437:264-9. Unique Identifier : AIDSLINE MED/85197359
Clumeck N; Sonnet J; Taelman H; Cran S; Henrivaux P
During the years from 1979 until 1983, 40 cases of CDC-defined AIDS were seen in Belgium . Only two patients were Belgian male homosexuals. The other patients were Central Africans who lived in Belgium or who had travelled to Belgium for medical care. There was no evidence of an un
Umiel T; Friedman E; Luria D; Cohen IJ; Kaplinsky H; Netzer L; Pecht M; Trainin N; Zaizov R
The immune function was assessed in 22 children, adolescents and young adults with asymptomatic hemophilia, and 15 with thalassemia, in Israel . Five patients with hemophilia and two with thalassemia were found to be severely abnormal, having cutaneous anergy, very low T-helper cell
Ann N Y Acad Sci. 1984;437:340-9. Unique Identifier : AIDSLINE MED/85197370
Ammann AJ; Wara DW; Cowan MJ
Approximately 40 to 50 infants and children with similar epidemiologic, clinical, and laboratory features of AIDS have been described. The occurrence of significant numbers of patients with PAIDS in geographic areas that are associated with similar risk factors and clinical features of AIDS suggests a common cause. Im
Immunologic and conventional laboratory studies were done in 135 previously untreated subjects including 28 (20.7%) symptom-free homosexuals and 74 (54.8%) with ARC and 33 (24.5%) with AIDS. More than half of all patients had abnormal percentages of lymphocytes, percentages of T3+ cells, percentage and absolute number
Ann N Y Acad Sci. 1984;437:518-25. Unique Identifier : AIDSLINE MED/85197395
Laurence J; Gottlieb AB; Kunkel HG
Supernatants from PBMC obtained from certain patients with AIDS or its prodrome were capable of depressing pokeweed mitogen-driven immunoglobulin production and the proliferative response of T cells to specific antigen. These soluble suppressor factors (SSF) were present in uniquely high concentrations, and were the p
Ann N Y Acad Sci. 1984;437:549-53. Unique Identifier : AIDSLINE MED/85197401
Handzel ZT; Galili-Weisstub E; Burstein R; Berner Y; Pecht M; Netzer L; Trainin N; Barzilai N; Levin S; Bentwich Z
We have described several immune derangements found in a clinically asymptomatic group of 117 male homosexuals (MHS) in Israel . These consisted of a marked decrease in TH and TS cells, decreased NK and allogeneic response, and increased levels of acid labile alpha-interferon and ci
A human T-lymphoblastoid cell line, TCL-Fuj, constitutively produced a large amount of human gamma interferon (IFN) in culture fluids and has sustained stable IFN production for more than two years. When cells were incubated in RPMI-1640 medium with 10% fetal calf serum for three days, IFN activity was detectable at a
By November 7, 1983, 24 cases of AIDS in the United Kingdom had been reported to the Communicable Disease Surveillance Centre. At the same time an increasing number of homosexual men with unexplained lymphadenopathy syndrome (LAS) have been seen in our department. Between December 1982
Ann N Y Acad Sci. 1984;437:383-93. Unique Identifier : AIDSLINE MED/85197374
Gold JW; Armstrong D
The cause of AIDS is unknown. In the absence of a specific etiologic agent or diagnostic test, a case can only be recognized when complications of the immune deficiency such as infection or Kaposi s sarcoma occur. Defective T-cell function is the principal immunologic defect; there are also defects, however, in B-cell
Ann N Y Acad Sci. 1984;437:563-7. Unique Identifier : AIDSLINE MED/85197404
Falk LA Jr; Byington R; Silva DP
T-lymphocytes from three species of New World monkeys were susceptible to transformation in vitro with human T-cell leukemia virus. Marmoset T-lymphocytes transformed in vitro with HVS or HVA, T-lymphotropic herpesviruses of New World monkeys, were also transformed with HTLV resulting in doubly transformed T-cells. Th
Ann N Y Acad Sci. 1984;437:192-9. Unique Identifier : AIDSLINE MED/85197352
Goedert JJ
Current data suggest that a transmissible agent causes AIDS, but undefined cofactors may also play a role. This paper reviews published data on the relationship between recreational drugs and immune alterations, with particular emphasis on nitrite inhalant (NI) use by homosexual men. In our original cohort of 15 homos
Speelman JD; ter Schegget J; Bots GT; Stam J; Verbeeten B Jr
The case of a 40-year-old homosexual male with A.I.D.S. (Acquired Immune Deficiency Syndrome) and P.M.L. (Progressive Multifocal Leukoencephalopathy) is described. The importance of a brain biopsy for diagnostic procedures, especially in the case of a patient with A.I.D.S. is stressed. The diagnosis P.M.L. has been ma
Histologic material from 52 autopsies of persons who had died of the acquired immunodeficiency syndrome (AIDS) were reviewed. The study group included 23 Haitians, 19 homosexual men, five intravenous drug abusers, two hemophiliacs (type A), and three persons at unknown risk. Nineteen of the patients (36.5 per cent) ha
Acta Med Scand. 1985;217(2):213-24. Unique Identifier : AIDSLINE MED/85195510
Gerstoft J; Nielsen JO; Dickmeiss E; Ronne T; Platz P; Mathiesen L
Twenty Danish patients with the acquired immunodeficiency syndrome (AIDS) had been diagnosed by January 1984, 14 of them after 1982. Eighteen patients were male homosexuals, 8 of whom had visited the USA after 1979, 2 were heterosexual males with a history of sexual contacts in Central Africa, suggesting a transmissio
Am J Pathol. 1985 May;119(2):253-63. Unique Identifier : AIDSLINE MED/85196374
Giddens WE Jr; Tsai CC; Morton WR; Ochs HD; Knitter GH; Blakley GA
A peculiar fibroproliferative syndrome called retroperitoneal fibromatosis (RF) has been observed in Macaca nemestrina, Macaca mulatta, Macaca fascicularis, and Macaca fuscata at the Washington Regional Primate Research Center. RF is characterized by the aggressive proliferation of highly vascular fibrous tissue subja
A man with acquired immunodeficiency syndrome and multiple opportunistic infections developed central nervous system signs, and results of computed tomography suggested brain abscess. Histologic study and culture of material obtained from the brain biopsy specimen revealed Aspergillus. The clot from a peripheral venou
Kramer HJ; Heppe M; Weiler E; Backer A; Liddiard C; Klingmuller D
In the present study natriuretic activity and digoxin-like immunoreacting activity (DLIA) were determined in small molecular weight (MW) fractions of urine from healthy subjects during low (35 mmol/day) and high (greater than 400 mmol/day) sodium intake by bioassay and by a radioimmunoassay for digoxin, respectively.
Am J Med. 1985 May;78(5):737-41. Unique Identifier : AIDSLINE MED/85196200
Gelmann EP; Preble OT; Steis R; Lane HC; Rook AH; Wesley M; Jacob J; Fauci A; Masur H; Longo D
Thirty consecutive patients with the acquired immune deficiency syndrome were treated with intramuscular human lymphoblastoid interferon for Kaposi s sarcoma. Patients were divided into three groups receiving 7.5 million units/m2 per day, 15 million units/m2 per day, or 25 million units/m2 per day for 28 days. Because
A well-documented case of acquired immunodeficiency syndrome (AIDS) with diffuse lymphadenopathy and disseminated mycobacteriosis in whom serial Ga-67 studies were performed is presented.
Recent case reports have suggested that the acquired immunodeficiency syndrome (AIDS) may be associated with cancers other than Kaposi s sarcoma (KS). We have used the population-based registries of the Surveillance, Epidemiology, and End Results (SEER) Program to examine these relationships on a statistical basis by
Levels of lymphocyte responsiveness to T- and B-cell-specific mitogens and expressions of Ia, T4, T8, and T11 surface markers were monitored during the course of Simian acquired immunodeficiency syndrome (SAIDS) in four Rhesus macaques that either died or became ill and survived. The monkey that died showed progressiv
Hartman B; Koss M; Hui A; Baumann W; Athos L; Boylen T
Sixty-one diagnostic biopsies for Pneumocystis carinii pneumonia were performed on 40 homosexual male patients with acquired immunodeficiency syndrome (AIDS), using flexible fiberoptic bronchoscopy. Bronchial brushings and bronchoalveolar lavage were performed in conjunction with the biopsy in 58 and 29 bronchoscopies
We recently reported a Simian Acquired Immunodeficiency Syndrome (SAIDS) in rhesus macaques at the California Primate Research Center. Here, we studied in vitro lymphocyte response to the mitogens Concanavalin A (Con A), phytohemagglutinin (PHA) and pokeweed mitogen (PWM) with and without interleukin 2 (
Forty-four episodes of Pneumocystis carinii pneumonia (PCP) occurred in 36 of 70 patients with the acquired immunodeficiency syndrome. Thirty-four patients with 40 episodes of PCP were treated with trimethoprim-sulfamethoxazole. Therapy was successful in 18 episodes (45%), but was unsuccessful in 15 episodes (37.5%).
At endoscopy, a 30-year-old man with acquired immune deficiency syndrome (AIDS), Kaposi s sarcoma, diarrhea, and unexplained malabsorption showed erythematous macular duodenal lesions consistent with Whipple s disease by histology and electron microscopy. Symptoms did not respond to tetracycline. Subsequent cultures r
Medicine (Baltimore). 1985 May;64(3):145-56. Unique Identifier : AIDSLINE MED/85187485
Lederman HM; Winkelstein JA
We have defined the clinical presentation and course of X-linked agammaglobulinemia (X-LA) by means of a multi-center retrospective survey of 96 patients. Infections were the most common presenting feature of patients with X-LA. The most frequent infections involved the upper respiratory tract (75%), lower respiratory
Medicine (Baltimore). 1985 May;64(3):203-13. Unique Identifier : AIDSLINE MED/85187489
Gold JW; Weikel CS; Godbold J; Garcia C; Urmacher C; Cunningham-Rundles S; Koziner B; Pollack M; Gallo RC; Sarngadharan MG; et al
Ninety-three homosexual men with persistent lymphadenopathy were followed at the Memorial Sloan-Kettering Cancer Center for a mean period of 20.8 months. Histories and serologic evidence of a number of previous infections were common, but the lymphadenopathy was not due to recognizable infections or neoplastic disease
Acquired immunodeficiency syndrome (AIDS) manifests a profound deficiency in cellular and humoral immunity causing opportunistic infections with high mortality. Intensive searching for accurate diagnosis, effective treatment, and reliable preventions are in progress. Diagnostic findings include lymphocytopenia, decrea
Peripheral blood lymphocytes from 30 patients with haemophilia A were investigated for the expression of six activation-linked cell surface antigens as well as with regard to the relative proportions and total numbers of Leu-3a and Leu-2a positive cells. Twenty-nine of the haemophilia patients showed no clinical sympt
Am J Med. 1985 May;78(5):728-36. Unique Identifier : AIDSLINE MED/85196199
Silverman BA; Rubinstein A
Twenty-seven of 33 patients with the acquired immune deficiency syndrome (AIDS) or AIDS-related complex (16 adults and 17 children) demonstrated significant elevation of serum lactate dehydrogenase activity, occurring in the isomorphic distribution. Serum lactate dehydrogenase activity was the highest in all nine pati
Levy JA; Tobler LH; McHugh TM; Casavant CH; Stites DP
Peripheral blood mononuclear cells from patients with acquired immune deficiency syndrome (AIDS) and from healthy controls have been cultured in vitro in the presence of phytohemagglutinin (PHA) and interleukin 2 ( IL-2 ). The T-cell subsets that grew were of both helper
Heitmann M; Bauer R; Bienzle U; Vossmann D; Orfanos CE
Investigations on 147 homosexual men in Berlin-West (17-57 years old, kappa = 32 years) revealed the presence of lymphadenopathy in 90 cases (61.2%). In addition, the Th/Ts-ratio was significantly reduced in the entire homosexual group compared to a control group of heterosexual men (n = 13) of comparable age [2P(z) =
McDougal JS; Hubbard M; Nicholson JK; Jones BM; Holman RC; Roberts J; Fishbein DB; Jaffe HW; Kaplan JE; Spira TJ; et al
Immune complex assays (and other immunologic tests) were performed on sera from 162 patients with the acquired immunodeficiency syndrome (AIDS) and 275 AIDS-related subjects. Immune complexes were detected in 89% of AIDS patients and 93% of homosexual men with lymphadenopathy. Immune complex levels in AIDS patients we
Nine patients with the acquired immunodeficiency syndrome (AIDS) were studied for suppressor cell activity utilizing an allogeneic mixed lymphocyte culture technique. The patients studied had opportunistic infections and a high incidence of intravenous drug abuse. T lymphocytes of the AIDS patients showed a consistent
Hofmann B; Odum N; Platz P; Ryder LP; Svejgaard A; Neilsen JO
The lymphocyte transformation response in vitro to mitogens (phytohaemagglutinin, concanavalin A, and pokeweed mitogen) and antigens (purified protein derivative and tetanus) was studied in three patients with acquired immunodeficiency syndrome (AIDS), three patients with pre-AIDS, and six healthy controls before and
Br Med J (Clin Res Ed). 1985 Apr 20;290(6476):1176-8. Unique Identifier : AIDSLINE MED/85175877
Mortimer PP; Jesson WJ; Vandervelde EM; Pereira MS
Antibody to human T lymphotropic virus type III (anti-HTLV-III) was sought in 2150 patients in three groups at risk with a radioimmunoassay and an immunofluorescence test. Results by the two methods were closely concordant. Anti-HTLV-III was already present in some British homosexuals in 1980 and in some British haemo
Br Med J (Clin Res Ed). 1985 Apr 27;290(6477):1243-6. Unique Identifier : AIDSLINE MED/85175910
Bartholomew C; Charles W; Saxinger C; Blattner W; Robert-Guroff M; Raju C; Ratan P; Ince W; Quamina D; Basdeo-Maharaj K; et al
Adult T cell leukaemia/lymphoma was first recognised as a clinical entity in southwest Japan . Subsequently the Caribbean has been found to be another area where the disease is endemic, and sporadic cases have been identified in different parts of the world. The human T cell leukaemi
Cancer Res. 1985 Jun;45(6):2849-52. Unique Identifier : AIDSLINE MED/85176722
Clark JW; Robert-Guroff M; Ikehara O; Henzan E; Blattner WA
A serological survey for the presence of antibodies against the human T-cell leukemia virus, type 1 (HTLV-1) in patients seen at the Chubu Hospital in Okinawa was undertaken. All patients with the clinicopathological diagnosis of adult T-cell leukemia-lymphoma were positive. These cases had the characteristic features
Jeong G; Ralph P; Nakoinz I; Saiki O; Cunningham-Rundles C
We previously defined three categories of B-cell defects in common varied immunodeficiency (CVI): failure to produce IgG and IgA in response to T cell-dependent (TD) stimulation by Staphylococcus bacteria (Sac) plus pokeweed mitogen or B-cell inducing factor (BIF), failure to produce any immunoglobulin, and failure of
The ability of human T cell leukemia/lymphoma virus (HTLV)-I to alter the function of infected T lymphocytes was examined directly by investigating the properties of an antigen-specific T cell clone before and after transformation with HTLV-I. Following infection, the T4 antigen-specific clone manifested a tenfold inc
Four human T cell lines, TL-Mor, TL-Su, TL-TerI, and TL-OmI, carrying human T cell leukemia virus (HTLV), were established previously. TL-Mor, TL-Su, and TL-TerI were derived from interleukin 2 ( IL-2 )-dependent parental cell lines cloned from peripheral blood leukocyte
Yodoi J; Okada M; Tagaya Y; Teshigawara K; Fukui K; Ishida N; Ikuta K; Maeda M; Honjo T; Osawa H; et al
Three rat lymphoid cell lines (TARS-1, TARL-2, and TART-1) (12) transformed by human T cell leukemia/lymphoma virus I (HTLV-I) had rearrangement of the beta chain gene of the T cell antigen receptor, and had integrated proviral DNA from HTLV-I in their genomes. As is the case with adult T cell leukemia (ATL)-derived h
JAMA. 1985 May 17;253(19):2843-6. Unique Identifier : AIDSLINE MED/85185781
Boss LP; Levine PH; Hanes RS
During a five-month period in 1982, diagnoses were made of Burkitt s lymphoma in three children and nasopharyngeal carcinoma in three teenagers who were residents of a small geographic area of central Texas. The observed number of these two Epstein-Barr virus-related cancers was significantly greater than the number e
Klin Wochenschr. 1985 Mar 1;63(5):233-5. Unique Identifier : AIDSLINE MED/85186377
Hunsmann G; Schneider J; Bayer H; Kurth R; Werner A; Brede HD; Erfle V; Mellert W; Brodt HR; Bergmann L; et al
In 1984 10,281 sera were collected in the FRG and examined for antibodies to HTLV-III (LAV) with an enzyme-linked immunosorbent assay and confirmative tests. Of the German AIDS patients 81% have antibodies. Individuals belonging to AIDS risk groups, homosexuals, haemophiliacs and i.v. drug abusers, have antibody frequ
Klin Wochenschr. 1985 Mar 15;63(6):241-51. Unique Identifier : AIDSLINE MED/85186378
Doerr HW; Braun R; Munk K
Cytomegalic inclusion disease (CID) is caused by a horizontally or vertically transmitted human herpes virus infection and may persist for life without obvious clinical symptoms. A serious course of horizontal primary and recurrent infections, however, is often observed in immunocompromised persons such as recipients
N Engl J Med. 1985 May 16;312(20):1293-6. Unique Identifier : AIDSLINE MED/85188110
Feorino PM; Jaffe HW; Palmer E; Peterman TA; Francis DP; Kalyanaraman VS; Weinstein RA; Stoneburner RL; Alexander WJ; Raevsky C; et al
To investigate whether infection with human T-cell lymphotropic virus/lymphadenopathy-associated virus (HTLV-III/LAV) may be persistent in asymptomatic persons and to correlate infection with seropositivity, we performed virologic and serologic studies in 25 of 30 persons who were identified as being at high risk for
Human T-cell lymphotropic retrovirus type III (HTLV-III), also called lymphadenopathy-associated virus (LAV), has been identified as the aetiological agent of acquired immune deficiency syndrome (AIDS). The sera of most patients with AIDS or AIDS-related complexes, and of asymptomatic individuals infected with HTLV-II
Proc Natl Acad Sci U S A. 1985 Apr;82(8):2277-81. Unique Identifier : AIDSLINE MED/85190480
Fujisawa J; Seiki M; Kiyokawa T; Yoshida M
Promoter function for gene expression of the long terminal repeat (LTR) of human T-cell leukemia virus type I (HTLV-I) was studied by constructing plasmids containing the LTR sequence. The gene encoding chloramphenicol acetyltransferase (CATase) was linked to an HTLV-I LTR sequence (pLTR-CAT) by replacing the simian v
A dot immunobinding (DIB) technique was applied to the demonstration of antibodies to human T-lymphotropic virus type III (HTLV-III). By this technique IgG antibodies to HTLV-III were demonstrated in six of six Swedish patients with acquired immune deficiency syndrome and in 37 of 39 (95%) Swedish homosexual men with
Science. 1985 May 31;228(4703):1091-4. Unique Identifier : AIDSLINE GENBANK/K03455
Allan JS; Coligan JE; Barin F; McLane MF; Sodroski JG; Rosen CA; Haseltine WA; Lee TH; Essex M
Antibodies from the serum of patients with the acquired immune deficiency syndrome (AIDS) or with the AIDS-related complex and from the serum of seropositive healthy homosexuals, recognize two major glycoproteins in cells infected with human T-cell lymphotropic virus type III (HTLV III). These glycoproteins, gp160 and
Science. 1985 May 31;228(4703):1094-6. Unique Identifier : AIDSLINE MED/85192538
Barin F; McLane MF; Allan JS; Lee TH; Groopman JE; Essex M
In this study, two glycoproteins (gp160 and gp120) that are encoded by human T-cell lymphoma virus type III (HTLV-III) were the antigens most consistently recognized by antibodies found in patients with the acquired immune deficiency syndrome (AIDS) and with the AIDS-related complex (ARC) and in healthy homosexual mal
S Afr Med J. 1985 Apr 27;67(17):665-8. Unique Identifier : AIDSLINE MED/85192803
Botha MC; Jones M; de Klerk WA; Yamamoto N
Antibodies which probably indicate infection with human T-cell leukaemia virus type I (HTLV-I) were determined in three species of non-human primates from several localities. A significant prevalence among chacma baboons and vervet monkeys was confirmed. According to sero-epidemiological evidence that HTLV-I infection
S Afr Med J. 1985 Apr 27;67(17):668-71. Unique Identifier : AIDSLINE MED/85192804
Botha MC; Jones M; de Klerk WA; Yamamoto N
The prevalence of serum antibodies which probably indicate infection with a human T-cell leukaemia virus type I was determined among random population samples of more than 100 healthy black individuals in several localities in Transvaal. The percentage of seropositive subjects increases northwards and eastwards, where
Alymbaeva DB; Miller GG; Rakovskaia IV; Bykovskii AF
A suspension culture of human T-lymphoblasts HUT-102 producing type C oncovirus (HTLV) was examined electron microscopically. Control decontaminated HUT-102 cells spontaneously contaminated with M. orale and exogenously infected with M. pneumoniae were examined in ultrathin sections. The variation statistics method de
Clinical data and histologic sections of the liver, including immunohistochemical studies for hepatitis B surface and core antigens, were reviewed in 42 autopsy cases of the acquired immune deficiency syndrome (AIDS). Hepatomegaly, elevation of serum transaminases, and mild elevation of alkaline phosphatase were commo
Ann Intern Med. 1985 Jun;102(6):737-41. Unique Identifier : AIDSLINE MED/85197242
Savona S; Nardi MA; Lennette ET; Karpatkin S
Since November 1982 we have seen an association of thrombocytopenic purpura with chronic narcotic addiction in 70 patients with a mean platelet count of 53000 +/- 4000 (SE); 33 had stopped taking intravenous drugs for an average of 21.2 +/- 4.7 months; 13 of 15 had elevated antibody titers for a virus related to the a
Ann Intern Med. 1985 Jun;102(6):747-52. Unique Identifier : AIDSLINE MED/85197244
Broaddus C; Dake MD; Stulbarg MS; Blumenfeld W; Hadley WK; Golden JA; Hopewell PC
The efficacy of bronchoalveolar lavage and transbronchial biopsy in diagnosing lung infection was determined in 276 fiberoptic bronchoscopic examinations done on 171 patients with known or suspected acquired immunodeficiency syndrome. Of 173 pathogens (Pneumocystis carinii, cytomegalov
Ann Intern Med. 1985 Jun;102(6):753-7. Unique Identifier : AIDSLINE MED/85197245
Lederman MM; Ratnoff OD; Evatt BL; McDougal JS
Antibody to lymphadenopathy-associated virus (LAV) was assayed in 461 serum and plasma samples that had been obtained from 149 patients with classic hemophilia and 64 controls and stored for periods as long as 18 years. No control or patient samples obtained before 1980 contained antibody to this retrovirus. The preva
Ann Intern Med. 1985 Jun;102(6):800-13. Unique Identifier : AIDSLINE MED/85197261
Fauci AS; Masur H; Gelmann EP; Markham PD; Hahn BH; Lane HC
The acquired immunodeficiency syndrome continues to be a major public health problem in the United States , and recently its spread worldwide has accelerated. The syndrome is caused by a human retrovirus transmitted by sexual contact and via blood or blood products. The virus has been i
Annu Rev Med. 1985;36:545-62. Unique Identifier : AIDSLINE MED/85197764
Weiss A; Hollander H; Stobo J
Acquired immunodeficiency syndrome indicates opportunistic infection or unusual malignancy associated with a marked deficiency of cell mediated immunity in the absence of any other cause of the immune defect. This review examines epidemiology, virology, and immunology associated with this disorder. The syndrome appear
Tubuloreticular inclusions (TRI) have been observed in the rough endoplasmic reticulum of blood lymphocytes and monocytes in two cases of Reye s syndrome initiated by influenza infections. Tubuloreticular inclusions are seen in these mononuclear leukocytes during the acute phase of illness, but not during convalescenc
Am J Med. 1985 May;78(5):811-6. Unique Identifier : AIDSLINE MED/85196212
Newell GR; Mansell PW; Spitz MR; Reuben JM; Hersh EM
Early reports of the acquired immune deficiency syndrome (AIDS) in homosexual men suggested that the cause might be related to homosexual life-style practices, including use of recreational drugs. Inhalation of volatile nitrites is a possible contributing factor in AIDS because their pharmacologic properties lead to t
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