Transmission of simian acquired immunodeficiency syndrome (SAIDS) with type D retrovirus isolated from saliva or urine. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Transmission of simian acquired immunodeficiency syndrome (SAIDS) with type D retrovirus isolated from saliva or urine.

Proc Soc Exp Biol Med. 1984 Dec;177(3):491-4. Unique Identifier : AIDSLINE MED/85088576
Gravell M; London WT; Lecatsas G; Hamilton RS; Houff SA; Sever JL

Abstract: Saliva and urine specimens from rhesus monkeys with SAIDS were found to contain a type D retrovirus related to Mason-Pfizer monkey virus (MPMV) which has been linked etiologically to SAIDS. Virus isolates from saliva and urine were shown to have the characteristics of the SAIDS agent by their reverse transcriptase divalent cation preference for synthetic template-primers, production of characteristic cytopathology in Raji cells and antigenic relatedness to MPMV as determined by enzyme-linked immunosorbent assay (ELISA) and competition radioimmunoassay (RIA). Electron micrographs of parotid tissue from an animal with SAIDS also showed budding particles with type D retrovirus morphology. A tissue culture grown virus isolate from urine of an animal with SAIDS, produced SAIDS when inoculated into two normal juvenile rhesus monkeys. Since saliva and urine of monkeys with SAIDS contain infectious SAIDS virus, they are likely sources of virus by which the disease is naturally transmitted. Thus, care should be taken to avoid contact of normal and infected animals.
Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY/TRANSMISSION/ *VETERINARY Animal Antigens, Viral/IMMUNOLOGY Cations, Divalent Macaca mulatta Microscopy, Electron *Monkey Diseases Retroviridae/ENZYMOLOGY/*ISOLATION & PURIF/PATHOGENICITY Reverse Transcriptase/METABOLISM Saliva/MICROBIOLOGY Urine/MICROBIOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/microbiology/transmission/KWDveterinaryanimalantigens,viral/immunologycations,divalentmacacamulattamicroscopy,electronKWDmonkeydiseasesretroviridae/enzymology/KWDisolation&purif/pathogenicityreversetranscriptase/metabolismsaliva/microbiologyurine/microbiologyjournalarticle
850430
M8540112

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1985. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1985. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .