[Acquired immunodeficiency syndrome, chronic coccidiosis and Salmonella typhimurium septicemia in a couple from Zaire. Immunological functions and attempt at immunostimulation by thymopentin]

Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

[Acquired immunodeficiency syndrome, chronic coccidiosis and Salmonella typhimurium septicemia in a couple from Zaire. Immunological functions and attempt at immunostimulation by thymopentin]

Schweiz Med Wochenschr. 1984 Nov 17;114(46):1645-50. Unique Identifier : AIDSLINE MED/85090285
Martin-Du Pan RC; Roth A; Stamenkovic AR; Hirschel B; Male PJ; Bolla K; Despond JP; Jeannet M; Dayer JM

Abstract: A clinical review of a young couple from Zaire with acquired immunodeficiency syndrome (AIDS) is reported. Both had opportunistic infections such as Salmonella typhimurium septicemia, genital herpes and digestive candidiasis. The husband was hospitalized for diarrhea from Isospora belli infection and for hemoptysis from an aspergilloma. His wife was admitted for a thoracic herpes zoster infection and left hemiplegia preceding subacute encephalitis. In both patients the biological immune functions were compatible with AIDS: presence of antibody against lymphadenopathy virus, decreased in OKT4+/OKT8+ ratio, and lack of lymphocyte response to mitogens which was partially restored in vitro after addition of interleukin 2 and thymopentin (TP-5) in the husband. In vitro monocyte cultures showed increased production of prostaglandins E2 (PGE2) and a slight decrease in interleukin 1 production. The symptomatic treatments and an attempt at immunostimulation with TP-5 in the husband are described.

Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/IMMUNOLOGY/ THERAPY Adult Case Report Coccidiosis/*COMPLICATIONS English Abstract Female Herpes Genitalis/COMPLICATIONS Hormones, Synthetic/THERAPEUTIC USE Human Immunization Immunologic Techniques Male Peptide Fragments/THERAPEUTIC USE Salmonella typhimurium Salmonella Infections/*COMPLICATIONS Septicemia/COMPLICATIONS Thymopoietins/THERAPEUTIC USE JOURNAL ARTICLE

850430
M8540111

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