Human adult T-cell leukaemia virus is distinct from a similar isolate of Japanese monkeys. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Human adult T-cell leukaemia virus is distinct from a similar isolate of Japanese monkeys.

J Gen Virol. 1984 Dec;65 ( Pt 12):2259-64. Unique Identifier : AIDSLINE MED/85081987
Yamamoto N; Okada M; Hinuma Y; Hirsch FW; Chosa T; Schneider J; Hunsmann G

Abstract: We have compared the structural polypeptides of an adult T-cell leukaemia (ATL) virus (ATLV) isolate from a Japanese patient with ATL with those of a similar virus derived from a Japanese macaque monkey. Both are distinct but related entities. Their core polypeptides p19 could not be distinguished, but p24, another core polypeptide, and their envelope glycopolypeptides differ. The human virus directs the synthesis of a single intracellular glycopolypeptide, gp68, while the macaque virus specifies two such glycopolypeptides, gp57 and gp50. Furthermore, the glycopolypeptides of both viruses are serologically distinct. Thus, these viruses represent subtypes of the ATLV family and the macaque virus is apparently not involved in human ATL.
Keywords: Animal Antigens, Viral/ANALYSIS Human HTLV-BLV Viruses/ANALYSIS/*CLASSIFICATION Isoelectric Point Macaca/*MICROBIOLOGY Molecular Weight Support, Non-U.S. Gov't Viral Proteins/*ANALYSIS/IMMUNOLOGY JOURNAL ARTICLE

KWDanimalantigens,viral/analysishumanhtlv-blvviruses/analysis/KWDclassificationisoelectricpointmacaca/KWDmicrobiologymolecularweightsupport,non-uKWDsKWDgov'tviralproteins/KWDanalysis/immunologyjournalarticle
850430
M8540091

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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