HTLV-III in symptom-free seronegative persons. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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HTLV-III in symptom-free seronegative persons.

Lancet. 1984 Dec 22;2(8417-18):1418-20. Unique Identifier : AIDSLINE MED/85085171
Salahuddin SZ; Groopman JE; Markham PD; Sarngadharan MG; Redfield RR; McLane MF; Essex M; Sliski A; Gallo RC

Abstract: Of 96 patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex and healthy individuals at risk for AIDS, 4 had no detectable antibodies to viral proteins, though human T-cell leukaemia (lymphotropic) virus type III was isolated from their lymphocytes. 3 of these subjects were symptom-free and 1 had lymphadenopathy. All 4 were sexual partners of patients with AIDS or AIDS-related complex. The occurrence of seronegative but virus-positive persons without clinical symptoms suggests that assays other than those detecting antibody to virus, perhaps based on detection of viral antigens or immune complexes, may be required to identify all infected individuals.
Keywords: Acquired Immunodeficiency Syndrome/*DIAGNOSIS/MICROBIOLOGY Adult Antibodies, Viral/*ANALYSIS Carrier State/*DIAGNOSIS/MICROBIOLOGY Case Report Female Human HTLV-BLV Viruses/IMMUNOLOGY/*ISOLATION & PURIF Lymphocytes/MICROBIOLOGY Male Middle Age Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDdiagnosis/microbiologyadultantibodies,viral/KWDanalysiscarrierstate/KWDdiagnosis/microbiologycasereportfemalehumanhtlv-blvviruses/immunology/KWDisolation&puriflymphocytes/microbiologymalemiddleagesupport,non-uKWDsKWDgov'tjournalarticle
850430
M8540071

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