Mothers of infants with the acquired immunodeficiency syndrome. Evidence for both symptomatic and asymptomatic carriers. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Mothers of infants with the acquired immunodeficiency syndrome. Evidence for both symptomatic and asymptomatic carriers.

JAMA. 1985 Jan 18;253(3):363-6. Unique Identifier : AIDSLINE MED/85083378
Scott GB; Fischl MA; Klimas N; Fletcher MA; Dickinson GM; Levine RS; Parks WP

Abstract: Sixteen mothers of 22 infants with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex were followed up for evidence of clinical and immunologic abnormalities. With one exception, all mothers were clinically well at delivery but had evidence of immune dysfunction, with T-cell abnormalities and inverted T4/T8 ratios and/or elevation of serum immunoglobulin levels, particularly of IgG. During a follow-up period that averaged 30 months, AIDS developed in five of the mothers and AIDS-related complex in seven. Twelve subsequent pregnancies in 11 mothers produced four affected infants, suggesting that mothers can be persistently infected. Six mothers were delivered of subsequent infants who remain unaffected. These results suggest that the mothers are the likely source of infection in non-transfusion-associated cases of AIDS or AIDS-related complex in infants, that mothers have persistent immunologic abnormalities, and that they are at increased risk of developing AIDS or AIDS-related complex.
Keywords: Acquired Immunodeficiency Syndrome/GENETICS/IMMUNOLOGY/ *TRANSMISSION Adolescence Adult Carrier State/IMMUNOLOGY/*TRANSMISSION Female Follow-Up Studies Human Immunoglobulins/ANALYSIS Infant Leukocyte Count Lymphatic Diseases/TRANSMISSION Mothers Support, U.S. Gov't, P.H.S. Time Factors JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/genetics/immunology/KWDtransmissionadolescenceadultcarrierstate/immunology/KWDtransmissionfemalefollow-upstudieshumanimmunoglobulins/analysisinfantleukocytecountlymphaticdiseases/transmissionmotherssupport,uKWDsKWDgov't,pKWDhKWDsKWDtimefactorsjournalarticle
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M8540061

Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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