Multicentric angiofollicular lymph node hyperplasia (Castleman's disease) followed by Kaposi's sarcoma in two homosexual males with the acquired immunodeficiency syndrome (AIDS). NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Multicentric angiofollicular lymph node hyperplasia (Castleman's disease) followed by Kaposi's sarcoma in two homosexual males with the acquired immunodeficiency syndrome (AIDS).

Am J Clin Pathol. 1985 Jan;83(1):27-33. Unique Identifier : AIDSLINE MED/85094183
Lachant NA; Sun NC; Leong LA; Oseas RS; Prince HE

Abstract: Two homosexual men with the acquired immunodeficiency syndrome (AIDS) who developed a multicentric variant of angiofollicular lymph node hyperplasia (AFLNH) (Castleman's disease) and Kaposi's sarcoma are reported. Both had diffuse adenopathy, splenomegaly, and a systemic inflammatory state. Both had an absolute increase in Leu 1+ lymphocytes, which was associated with markedly decreased Leu 3+ lymphocytes, markedly increased Leu-2+ lymphocytes, and a very low Leu 3/2 ratio. The lymphocytes of both patients had a normal blastogenic response to PHA. The lymphocytes of patient 1 had a poor response to autologous or allogenic cells in the mixed lymphocyte culture reaction. AFLNH represents another lymphoreticular complication of AIDS. Given the interrelationships between AFLNH, the development of Kaposi's sarcoma, and the aggressive clinical course seen in our two patients and those in the literature, the aggressive use of lymph node biopsy may be an important prognostic tool for the patient with the acquired immunodeficiency syndrome.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/IMMUNOLOGY Adult Homosexuality Human Hyperplasia/ETIOLOGY/IMMUNOLOGY Killer Cells, Natural/PHYSIOLOGY Lymph Nodes/*PATHOLOGY Male Rosette Formation Sarcoma, Kaposi's/*ETIOLOGY/IMMUNOLOGY T-Lymphocytes/CLASSIFICATION JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplications/immunologyadulthomosexualityhumanhyperplasia/etiology/immunologykillercells,natural/physiologylymphnodes/KWDpathologymalerosetteformationsarcoma,kaposi's/KWDetiology/immunologyt-lymphocytes/classificationjournalarticle
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