Small noncleaved B cell Burkitt-like lymphoma with chromosome t(8;14) translocation and Epstein-Barr virus nuclear-associated antigen in a homosexual man with acquired immune deficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1985. The state of the art may have changed since the publication date.

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Small noncleaved B cell Burkitt-like lymphoma with chromosome t(8;14) translocation and Epstein-Barr virus nuclear-associated antigen in a homosexual man with acquired immune deficiency syndrome.

Am J Med. 1985 Jan;78(1):141-8. Unique Identifier : AIDSLINE MED/85094324
Petersen JM; Tubbs RR; Savage RA; Calabrese LC; Proffitt MR; Manolova Y; Manolov G; Shumaker A; Tatsumi E; McClain K; et al

Abstract: This case report describes new manifestations of the acquired immune deficiency syndrome (AIDS) in a promiscuous homosexual man. Investigation of upper gastrointestinal bleeding in the patient lead to discovery of a high-grade, small, noncleaved cell (Burkitt-like) gastroduodenal lymphoma with visceral and extralymphatic extension. Specific phenotyping of the lymphoma revealed that it was a monoclonal B cell lymphoma of mu kappa isotype. An in vitro cell line was established that was Epstein-Barr virus nuclear-associated antigen-positive. The lymphoma cells displayed a t(8;14) translocation similar to endemic African Burkitt lymphoma. Epstein-Barr virus genomes were identified in the lymphoma and an axillary lymph node biopsy specimen by molecular hybridization. These data strongly suggest that Epstein-Barr virus actively infected this patient. However, he showed normal Epstein-Barr virus-specific serologic responses, indicating an immune defect against the virus.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/IMMUNOLOGY Adult Burkitt's Lymphoma/*COMPLICATIONS/IMMUNOLOGY/PATHOLOGY Case Report Chromosome Abnormalities Chromosomes, Human, 13-15 Chromosomes, Human, 6-12 Genes, Viral Herpesvirus 4, Human/GENETICS/IMMUNOLOGY Homosexuality Human Karyotyping Male Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. *Translocation (Genetics) JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplications/immunologyadultburkitt'slymphoma/KWDcomplications/immunology/pathologycasereportchromosomeabnormalitieschromosomes,human,13-15chromosomes,human,6-12genes,viralherpesvirus4,human/genetics/immunologyhomosexualityhumankaryotypingmalesupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDs
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Copyright © 1985 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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