Ann Pathol. 1984 Sep-Nov;4(4):305-7. Unique Identifier : AIDSLINE MED/85072478
Bruneval P; Tricottet V; Camilleri JP; Reynes M; Daniel F
Herpes zoster blister was biopsied in an homosexual man presenting and AIDS. Ultrastructural findings were as follows: typical herpes virus particles, tubuloreticular inclusions (TRI), helical polyribosomes. The association of these three findings suggests that TRI may represent rather a particular way of cellular rea
Fecal samples of 61 patients were investigated for Cryptosporidium: it was identified in four cases of acquired immunodeficiency syndrome, five cases of lymphadenopathic syndrome, one case of immunosuppressive therapy. One person was immunocompetent but in close contact with one of the patient. The authors report clin
Three forms of Kaposi s sarcoma are now described: European and Mediterranean forms; they have been described first, are more frequent in old people, and characterised by angiomatous plaques and nodules; the evolution is slow with relapses and remissions. African forms. They are more frequent in young people; clinical
Smith PD; Ohura K; Masur H; Lane HC; Fauci AS; Wahl SM
The ineffective immune response in patients with the acquired immune deficiency syndrome (AIDS) contributes to severe and widespread infections and unrestricted growth by certain tumors. To determine whether monocyte dysfunction contributes to this immunosuppressed condition, we investigated monocyte chemotaxis in pat
Isospora belli is a cause of protracted diarrhea in immunocompromised patients. Acquired immunodeficiency syndrome (AIDS), seen mostly in homosexual men and narcotic addicts, predisposes affected persons to a number of opportunistic infections. As Isospora belli has been reported only once in this group, we report Iso
New trends of the clinical use of blood derivatives are mainly: The extensive use of concentrated RBC (Haematocrit 72 +/- 2%) prepared from blood collected in CPD-adenin bags and stored at 4 degrees C up to 35 days. The selective use of packed RBC resuspended in SAG-mannitol solutions, providing long conservation of p
Dtsch Med Wochenschr. 1984 Dec 21;109(51-52):1955-62. Unique Identifier : AIDSLINE MED/85076294
Helm EB; Bergmann L; Elbert M; Mitrou P; Stille W
Since November 1982, patients with symptoms suggesting a lymphadenopathy syndrome (LAS) or acquired immune deficiency syndrome (AIDS), as well as their contacts and persons in high risk groups were examined as out-patients. The examinations have now been concluded in 101 patients. The patients were divided into 3 grou
Cancer Immunol Immunother. 1984;18(3):141-8. Unique Identifier : AIDSLINE MED/85074165
Munn CG; Reuben JM; Hersh EM; Mansell PW; Newell GR
Surface marker expression on peripheral blood mononuclear cells (PBMC) was evaluated daily in PHA- and PWM-stimulated cultures of eight AIDS patients and eight normals. Before culture, the patients cells showed the characteristic decrease in OKT 4+ cells (normals 40.4%, patients 22.3%; P less than 0.001), increase in
Blood lymphocytes from 8 patients with common variable immunodeficiency (CVID), 5 patients with signs of polyclonal activation of the immune system (1 SLE, 3 AILAP, 1 NHL) and 6 patients with various granulomatous diseases were examined for their capacity to produce lymphokines in vitro. Lymphocytes from 16 healthy in
Male prodromal homosexuals and patients with acquired immune deficiency syndrome (AIDS) exhibited similar immunological abnormalities but by different degrees. A reduction in the number of circulating T lymphocytes bearing the T-4 surface marker led to an altered ratio of Th to Ts subpopulations in both groups of subj
Moss AR; McCallum G; Volberding PA; Bacchetti P; Dritz S
A population-based survival study was done for all cases of the acquired immune deficiency syndrome diagnosed in the city of San Francisco through May 1983. Follow-up was obtained for 165 of 173 diagnosed cases. Median survival among 75 patients presenting with Kaposi s sarcoma (KS) alone was 21 months. Median surviva
Many viruses, including retroviruses, are characterized by their specific cell tropism. Lymphadenopathy-associated virus (LAV) is a human lymphotropic retrovirus isolated from patients with acquired immune deficiency syndrome (AIDS) or related syndromes, that displays selective tropism for a subset of T lymphocytes de
Felix H; Rozenbaum W; Karabinis A; Rosenheim M; Brucker G; Duflo B; Gentilini M
Kaposi s Syndrome (K. S.) was defined as a virus induced immunogenic tumour responding to interferon. It can be used as a guideline for therapeutical trials in A. I. D. S. K. S. mortality is 13%. K. S. + O. I. (opportunistic infections) mortality reaches 70% and O. I. mortality is approximately 50%. Therefore treating
Reactivation of chronic, latent infection of Toxoplasma gondii has been observed previously in transplant patients and malignancies treated with immunosuppressive drugs. Recently it has emerged as the most common recognized central nervous system infection in acquired immunodeficiency syndrome (AIDS) patients, seen in
Suthanthiran M; Williams PS; Solomon SD; Rubin AL; Stenzel KH
The ability of the monoclonal antibody directed at the T3 antigen (anti-T3) to induce cytolytic activity was investigated since several agents that can activate T cells induce the acquisition of cytolytic activity in a variety of test systems. Pretreatment of human alloimmune memory cells, generated in primary long-te
Gravell M; London WT; Lecatsas G; Hamilton RS; Houff SA; Sever JL
Saliva and urine specimens from rhesus monkeys with SAIDS were found to contain a type D retrovirus related to Mason- Pfizer monkey virus (MPMV) which has been linked etiologically to SAIDS. Virus isolates from saliva and urine were shown to have the characteristics of the
Schweiz Med Wochenschr. 1984 Nov 17;114(46):1645-50. Unique Identifier : AIDSLINE MED/85090285
Martin-Du Pan RC; Roth A; Stamenkovic AR; Hirschel B; Male PJ; Bolla K; Despond JP; Jeannet M; Dayer JM
A clinical review of a young couple from Zaire with acquired immunodeficiency syndrome (AIDS) is reported. Both had opportunistic infections such as Salmonella typhimurium septicemia, genital herpes and digestive candidiasis. The husband was
The expression of HLA-DR (a class II histocompatibility antigen) on monocytes isolated from the peripheral blood of normal individuals and patients with acquired immune deficiency syndrome (AIDS) was investigated by the use of dual fluorescent staining and cytofluorometry. In animal models the absence of class II posi
Patow CA; Stark TW; Findlay PA; Steis R; Longo DL; Masur H; Macher AM
A homosexual man with AIDS developed multifocal KS with involvement of the palate, larynx, trachea, and esophagus. Symptoms included dysphagia and gagging with resultant inanition. Short-course local radiation therapy effectively resolved the mucosal KS lesions in the treated areas. Other otolaryngologic manifestation
C R Acad Sci III. 1984;299(9):351-3. Unique Identifier : AIDSLINE MED/85073722
Gessain A; Calender A; Strobel M; Lefait-Robin R; de The G
Antibodies to HTLV-1 (ELISA test using disrupted virus) were studied in different ethnic groups in French Guiana , including 135 blood donors from Cayenne, 97 Boni Blacks and 57 Wayana Indians from Maripasoula area, and 57 Hmong from
Chung Hua Min Kuo Wei Sheng Wu Chi Mien I Hsueh Tsa Chih. 1984 Aug;17(3):172-6. Unique Identifier : AIDSLINE MED/85075898
Lynn TC; Hsieh RP; Lin KT; Shen MC; Chen DS; Wang CH; Liu CH; Wang JH; Lai MY; Liou MF; et al
A total of 132 sera were studied for anti-HTLV antibodies using the Biotech ELISA test. Among the HTL group, two were, one, and the other two (+/-). Among 23 hemophiliacs one was. None of the lympho- and myelo-proliferative disorders, chronic uremics and normal controls showed positive results. Our results show that t
Ikeda M; Fujino R; Matsui T; Yoshida T; Komoda H; Imai J
A new gelatin particle agglutination test was developed for assay of natural antibodies to adult T-cell leukemia virus (ATLV/HTLV-I). Partially purified viral antigen from culture fluid of a virus-producer cell line was coated on artificial gelatin particle carriers. A high correlation was observed between the titers
Hoshino H; Tanaka H; Shimotohno K; Miwa M; Okada N; Sugimura T
DNAs were isolated from about 30 species of animals and digested with EcoRI. DNA fragments of about 20-30 kilobase pairs from pig and wild boar cells hybridized with a probe for the pol gene of human T-cell leukemia virus type I.
Feremans WW; Menu R; Goldman M; Schandene L; Portetelle D; Cleuter Y; Flament J; Dustin P; Wybran J; Burny A
The peripheral lymphocytes of a patient with prodromal acquired immune deficiency syndrome contained giant multivesicular bodies. These were specifically stained by immuno-gold labelled polyclonal antibodies against the major core protein p24 of bovine leukaemia virus and human T cell leukaemia virus I. Moreover, the
Sera of individuals infected with adult T-cell leukaemia virus (ATLV) react predominantly with the polypeptides gp68, p24 and p19. These polypeptides were isolated from ATLV-infected MT-2 cells and virus. The radioiodinated polypeptides were used to quantify respective antibodies in individual ATLV carrier sera. Heter
Yamamoto N; Okada M; Hinuma Y; Hirsch FW; Chosa T; Schneider J; Hunsmann G
We have compared the structural polypeptides of an adult T-cell leukaemia (ATL) virus (ATLV) isolate from a Japanese patient with ATL with those of a similar virus derived from a Japanese macaque monkey. Both are distinct but related entities. Their core polypeptides p19 could not be distinguished, but p24, another co
Growth of murine spontaneous and transplanted AKR T-cell lymphomas results in marked elevations of serum immunoreactive thymosin alpha 1. Thymosin alpha 1 is one of the peptide hormones believed to be secreted primarily by the thymic epithelium. This elevation, however, is not mediated by the thymus but rather, seems
We have previously shown that two human T-cell lines (HSB and 8402) derived from patients with childhood T-cell ALL (T-ALL) do not synthesize detectable mRNA for HLA-DR alpha. The DR alpha genes in both cell lines are hypermethylated relative to the same genes in T-cell lines infected with human T-cell leukemia virus
Human T-cell leukemia virus (HTLV) subgroup I is associated with adult T-cell leukemia (ATL), but in endemic areas a significant percentage of the normal population are also carriers of HTLV. A unique property of HTLV has been its capacity to transform normal human T-cells in vitro. We have examined the state of the H
Tanaka Y; Tozawa H; Koyanagi Y; Yamamoto N; Hinuma Y
A new mouse monoclonal antibody (HIEI, IgG1 type) that reacts with a cell surface glycoprotein of human lymphocytes was isolated. Membrane immunofluorescence assay showed that HIEI, like the anti-Tac monoclonal antibody, reacted preferentially with activated normal human T-cells and adult T-cell leukemia (ATL) virus (
Nature. 1984 Dec 20-1985 Jan 2;312(5996):757-60. Unique Identifier : AIDSLINE MED/85086249
Alizon M; Sonigo P; Barre-Sinoussi F; Chermann JC; Tiollais P; Montagnier L; Wain-Hobson S
Lymphadenopathy-associated virus (LAV) is a human retrovirus first isolated from a homosexual patient with lymphadenopathy syndrome, frequently a prodrome or a benign form of acquired immune deficiency syndrome (AIDS). Other LAV isolates have subsequently been recovered from patients with AIDS or pre-AIDS and all avai
Nature. 1984 Dec 20-1985 Jan 2;312(5996):760-3. Unique Identifier : AIDSLINE MED/85086250
Luciw PA; Potter SJ; Steimer K; Dina D; Levy JA
Retroviruses cause a wide variety of diseases in avian and mammalian species. Human acquired immune deficiency syndrome (AIDS) leads to collapse of the immune system and death by a wide variety of opportunistic infections; unusual forms of cancer are associated with this syndrome. Retroviruses have been recovered from
Acquired immune deficiency syndrome (AIDS) is characterized by opportunistic infections and by opportunistic neoplasms (for example, Kaposi s sarcoma). Persistent generalized lymphadenopathy (PGL) is epidemiologically associated with AIDS, especially in male homosexuals. A subset of T lymphocytes positive for the CD
Minerva Med. 1984 Nov 17;75(44):2653-8. Unique Identifier : AIDSLINE MED/85086843
Gabrielli GB; Nortilli R; Mezzelani P; Barbera A; Corrocher R; De Sandre G
Persistent Generalized Lymphadenopathy (PGL) is considered a possible early stage of AIDS (pre-AIDS), caused by the same virus and characterized by the same immunologic abnormalities. So far, no case of PGL has been reported in Italy : therefore we describe a typical clinical history
A 14-year-old native American female with common variable immunodeficiency was admitted for bone marrow transplantation. Preoperative evaluation showed a generalized lichenoid papular eruption present for several years. Light microscopy revealed expansion of the epidermis by atypical keratinocytes; electron microscopy
Thin section electron microscopy of tissue culture preparations of viruses associated with AIDS and SAIDS have shown that the mature particles have a similar morphology following budding from the cell membrane. The model provided explains the various core morphologies seen in section and provides a basis for identifyi
Variation in the structure of the long terminal repeat (LTR) element of human T-cell leukemia virus (HTLV) types has been noted (M. Seiki, S. Hattori, Y. Hirayama, and M. Yoshida (1983), Proc. Natl. Acad. Sci. USA 80, 3618-3622; K. Shimotohno, D. W. Golde, M. Miwa, T. Sugimura, and I. S. Y. Chen (1984), Proc. Natl. Ac
A case of acquired immune deficiency syndrome (AIDS) is reported in a young homosexual Venezuelan male. It is of special interest to note the association of cytomegalovirus polyvisceral infection, frequent during AIDS, and a brain immunoblastic lymphoma, an infrequent tumour in tha
Of 96 patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex and healthy individuals at risk for AIDS, 4 had no detectable antibodies to viral proteins, though human T-cell leukaemia (lymphotropic) virus type III was isolated from their lymphocytes. 3 of these subjects were symptom-free and 1
Lancet. 1984 Dec 22;2(8417-18):1444-6. Unique Identifier : AIDSLINE MED/85085183
Melbye M; Froebel KS; Madhok R; Biggar RJ; Sarin PS; Stenbjerg S; Lowe GD; Forbes CD; Goedert JJ; Gallo RC; et al
77 Scottish haemophiliacs and 22 Danish haemophiliacs were serologically tested for antibodies to human T-cell leukaemia virus III (HTLV-III). Since 1979 the Scottish patients had been treated largely with factor VIII concentrate produced in Scotland, whereas all but 2 of the Danish patients had received both locally
Can Med Assoc J. 1985 Jan 15;132(2):141-4. Unique Identifier : AIDSLINE MED/85073921
Jothy S; Gilmore N; El'Gabalawy H; Prchal J
Natural killer (NK) cells were studied in the lymph nodes of homosexual men with the persistent lymphadenopathy syndrome (PLS) and other signs of the disease complex related to the acquired immune deficiency syndrome (AIDS). The NK cells were identified by their Leu-7+ phenotype and enumerated in frozen sections of ly
A 66-year-old woman who developed simultaneously angioimmunoblastic lymphadenopathy (AILD) and Kaposi s sarcoma (KS) is reported. A parallel course of the two diseases was evident. After a relatively short course of corticosteroid therapy, the clinical and laboratory signs of AILD regressed, and the patient is in remi
JAMA. 1985 Jan 11;253(2):215-20. Unique Identifier : AIDSLINE MED/85083355
Hardy AM; Allen JR; Morgan WM; Curran JW
Population figures were obtained, and incidence rates of acquired immunodeficiency syndrome (AIDS) for the 12 months from June 1, 1983, to May 31, 1984, were estimated for single (never-married) men aged 15 years or older, intravenous (IV) drug users, Haitians living in the United States
JAMA. 1985 Jan 18;253(3):363-6. Unique Identifier : AIDSLINE MED/85083378
Scott GB; Fischl MA; Klimas N; Fletcher MA; Dickinson GM; Levine RS; Parks WP
Sixteen mothers of 22 infants with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex were followed up for evidence of clinical and immunologic abnormalities. With one exception, all mothers were clinically well at delivery but had evidence of immune dysfunction, with T-cell abnormalities and invert
Ten months before his death, a 36-year-old homosexual man with AIDS developed progressive symmetric paraparesis with muscle wasting, paresthesias, reflex-uninhibited bladder function, and bowel incontinence. Neuropathologic postmortem examination revealed a symmetric degeneration of the lateral and anterior pyramidal
Am J Gastroenterol. 1985 Jan;80(1):21-6. Unique Identifier : AIDSLINE MED/85094203
Steinberg JJ; Bridges N; Feiner HD; Valensi Q
Three cases of small bowel lymphoma in young homosexual men are presented. All three had acquired immune deficiency syndrome as demonstrated by demography, sexual history, cachexia, opportunistic infections by Cytomegalovirus, Pneumocystis carinii, atypical Mycobacterium, Candida, and/or evidence of immune deficiency,
Am J Med. 1985 Jan;78(1):35-40. Unique Identifier : AIDSLINE MED/85094337
Wong B; Edwards FF; Kiehn TE; Whimbey E; Donnelly H; Bernard EM; Gold JW; Armstrong D
Serial quantitative blood cultures were performed before and during treatment in four patients with the acquired immune deficiency syndrome (AIDS) and Mycobacterium avium-intracellulare bacteremia. Initial colony counts were 350 to 28,000 cfu/ml, the counts declined substantially with treatment in two patients, and th
Am J Psychiatry. 1985 Jan;142(1):82-6. Unique Identifier : AIDSLINE MED/85094667
Dilley JW; Ochitill HN; Perl M; Volberding PA
Thirteen of 40 patients with acquired immune deficiency syndrome (AIDS) admitted to the wards of a large city hospital were seen by the staff of a psychiatric consultation service. Eleven were gay men and two were bisexual men. Depression was the stated reason for referral of 10 patients; of these, two met DSM-III cri
Am J Pathol. 1985 Jan;118(1):7-13. Unique Identifier : AIDSLINE MED/85094505
Lo SC; Liotta LA
Patients with the acquired immunodeficiency syndrome (AIDS) have a high incidence of Kaposi s sarcoma. The etiology, histogenesis, and neoplastic nature of this neoplasm have been controversial. We have therefore searched for transforming gene(s) associated with AIDS Kaposi s sarcoma. DNA from an AIDS patient s Kaposi
Two homosexual men with the acquired immunodeficiency syndrome (AIDS) who developed a multicentric variant of angiofollicular lymph node hyperplasia (AFLNH) (Castleman s disease) and Kaposi s sarcoma are reported. Both had diffuse adenopathy, splenomegaly, and a systemic inflammatory state. Both had an absolute increa
Medicine (Baltimore). 1985 Jan;64(1):36-48. Unique Identifier : AIDSLINE MED/85085501
Horsburgh CR Jr; Mason UG 3d; Farhi DC; Iseman MD
Thirteen cases of disseminated infection with Mycobacterium avium-intracellulare (MAI) seen at the National Jewish Hospital and Research Center and 24 cases from the literature were analyzed to define clinical and therapeutic features of the disease. Disseminated MAI infection was a disease of immunocompromised and ap
Ann Intern Med. 1985 Feb;102(2):186-8. Unique Identifier : AIDSLINE MED/85095355
Jacobs JL; Gold JW; Murray HW; Roberts RB; Armstrong D
Defects in T-cell function have been seen in patients with the acquired immunodeficiency syndrome. Although the cellular immune system plays a key role in host defense against Salmonella, there have been no detailed reports of salmonellosis in patients with this syndrome. We report our experience with salmonella infec
Seven Haitian and one white patient with the acquired immunodeficiency syndrome and Salmonella typhimurium bacteremia were identified over a 28-month period. In three patients bacteremia developed concurrently with an opportunistic infection associated with the acquired immunodeficiency syndrome. The remaining five pa
Ann Intern Med. 1985 Feb;102(2):203-5. Unique Identifier : AIDSLINE MED/85095360
Holtz HA; Lavery DP; Kapila R
Four parenteral drug abusers with the acquired immunodeficiency syndrome had nonmycobacterial actinomycetales infections. Three patients had nocardiosis and one developed a streptomyces lymphadenitis. There was pericardial involvement in two patients, and two patients died. Presumptive diagnoses were often incorrect,
Distinct populations of human B lymphocytes can be identified by their expression and/or co-expression of the B cell-restricted antigens B1 and B2. Dual fluorochrome staining and flow cytometric cell sorting permitted the isolation of the B1+B2+ and B1+B2- cells to homogeneity. In contrast, very few B1-B2+ cells were
Cancer. 1985 Jan 1;55(1):181-5. Unique Identifier : AIDSLINE MED/85073965
Miyamoto Y; Yamaguchi K; Nishimura H; Takatsuki K; Motoori T; Morimatsu M; Yasaka T; Ohya I; Koga T
Two siblings who developed adult T-cell leukemia (ATL) are presented. The patient and 7 of 26 healthy family members examined had the serum antibodies against ATL-associated antigens (ATLA). This family study shows that two main routes of transmission of human T-cell leukemia virus (HTLV) may be involved: one is the r
Cancer. 1985 Jan 15;55(2):453-9. Unique Identifier : AIDSLINE MED/85074026
Cheson BD; Samlowski WE; Tang TT; Spruance SL
The authors performed a retrospective analysis of 87 consecutive immunocompromised patients who underwent open-lung biopsy at the University of Utah Medical Center, Salt Lake City, Utah, from January 1971 to June 1982. A specific histologic diagnosis was obtained in 62 (71%) of the patients, 33 of whom had infections.
Cancer. 1985 Feb 1;55(3):615-9. Unique Identifier : AIDSLINE MED/85074053
Tannir N; Riggs S; Velasquez W; Samaan N; Manning J
Extensive generalized and subperiosteal bone resorption was demonstrated in a patient with adult T-cell lymphoma and marked hypercalcemia of unclear pathogenesis. Antibody to the human T-cell leukemia-lymphoma virus (HTLV) was present in the serum of the patient, consistent with the recently reported association of ad
The in vitro immune response to herpes simplex virus (HSV), type 1, strain 539, HSV type 2, strain 316D, and cytomegalovirus was studied in 20 patients (14 with acquired immune deficiency syndrome, four with the acquired immune deficiency syndrome-related symptom complex, and two s
Cytomegalovirus ( CMV ) and Epstein-Barr virus (EBV), frequently found in the acquired immune deficiency syndrome (AIDS), have been suspected of contributing to the latter immunodeficiency. The ability of normal HLA-identical sibling bone marrow to reconstitute an
A monoclonal antibody, designated HT462, is described which is specific for an antigen expressed in human T-cell leukemia/lymphoma virus (HTLV) preparations and by HTLV-infected cells. In indirect immunofluorescence assays, the antigen was detected on the surface of both HTLV-transformed producer and nonproducer cells
Goudsmit J; Miedema F; Wijngaarden-du Bois RJ; Roos MT; Schellekens PT; Coutinho RA; van der Noordaa J; Melief CJ
Immunoglobulin G (IgG) and IgM antibodies to human T-cell leukemia/lymphoma virus-I (HTLV-I)-associated membrane antigens (HTLV-I-MA) were assayed by indirect cytospin immunofluorescence, and IgG and IgM antibodies to purified HTLV-I were assayed by enzyme-linked immunosorbent assay in sera from 119 immunologically we
The third member of the human T-cell leukemia (lymphotropic) retrovirus family (HTLV-III) is a newly discovered retrovirus that has been closely associated with the acquired immunodeficiency syndrome (AIDS). In our application of an enzyme-linked immunosorbent assay (ELISA) for HTLV-III antibodies, 72 (82%) of 88 pati
N Engl J Med. 1985 Jan 31;312(5):265-70. Unique Identifier : AIDSLINE MED/85086186
Schupbach J; Haller O; Vogt M; Luthy R; Joller H; Oelz O; Popovic M; Sarngadharan MG; Gallo RC
We tested serum samples from Swiss subjects by three different assays based on enzyme-linked immunosorbent assay (ELISA) and Western blot techniques for antibodies to proteins associated with the recently discovered human T-cell leukemia/lymphoma virus HTLV-III, the putative etiologic agent for the acquired immunodefi
Science. 1985 Jan 11;227(4683):171-3. Unique Identifier : AIDSLINE MED/85090425
Sodroski J; Rosen C; Wong-Staal F; Salahuddin SZ; Popovic M; Arya S; Gallo RC; Haseltine WA
Human T-cell leukemia virus type III (HTLV-III) was recently identified as the probable etiologic agent of the acquired immune deficiency syndrome (AIDS). Here it is shown that, in human T-cell lines infected with HTLV-III, gene expression directed by the long terminal repeat sequence of this virus is stimulated by mo
A study was conducted of the genetic relation between human T-cell lymphotropic retroviruses and visna virus. The human T-cell lymphotropic viruses include those associated with T-cell malignancies (HTLV-I and HTLV-II) as well as the etiologic agent of the acquired immune deficiency syndrome (HTLV-III). Visna virus, a
Unexplained debilitating dementia or encephalopathy occurs frequently in adults and children with the acquired immune deficiency syndrome (AIDS). Brains from 15 individuals with AIDS and encephalopathy were examined by Southern analysis and in situ hybridization for the presence of
Science. 1985 Jan 18;227(4684):317-20. Unique Identifier : AIDSLINE MED/85090437
Derse D; Caradonna SJ; Casey JW
The functional activity of the promoter unit contained within the long terminal repeat (LTR) of bovine leukemia virus (BLV) was examined by monitoring transient expression of a heterologous gene placed under its control. Various cell lines were transfected with recombinant plasmids carrying the bacterial chloramphenic
Science. 1985 Jan 18;227(4684):320-2. Unique Identifier : AIDSLINE MED/85090438
Rosen CA; Sodroski JG; Kettman R; Burny A; Haseltine WA
The transcription initiation signals for retroviruses lie within the long terminal repeat (LTR) sequences that flank the integrated provirus. This study shows that factors present in cells infected with bovine leukemia virus (BLV) mediate transcriptional trans activation of the BLV LTR. This phenomenon is similar to t
Science. 1985 Feb 1;227(4686):484-92. Unique Identifier : AIDSLINE GENBANK/K02007
Sanchez-Pescador R; Power MD; Barr PJ; Steimer KS; Stempien MM; Brown-Shimer SL; Gee WW; Renard A; Randolph A; Levy JA; et al
The nucleotide sequence of molecular clones of DNA from a retrovirus, ARV-2, associated with the acquired immune deficiency syndrome (AIDS) was determined. Proviral DNA of ARV-2 (9737 base pairs) has long terminal repeat structures (636 base pairs) and long open reading frames encoding gag (506 codons), pol (1003 codo
The nucleotide sequence of the long terminal repeat sequence (LTR) of the human T-cell leukemia (lymphotropic) virus type III (HTLV-III) was determined. This virus is associated etiologically with the acquired immune deficiency syndrome. The LTR was found to be 634 base pairs in length with U3, R, and U5 regions of 45
Adult T-cell leukemia/lymphoma (ATLL) is a recently described distinct clinicopathologic entity characterized by a leukemic or lymphomatous proliferation of hyperlobulated peripheral T-cells, which is usually widespread at presentation and is associated with infection by a type C retrovirus. ATLL rarely is described o
Am J Med. 1985 Jan;78(1):141-8. Unique Identifier : AIDSLINE MED/85094324
Petersen JM; Tubbs RR; Savage RA; Calabrese LC; Proffitt MR; Manolova Y; Manolov G; Shumaker A; Tatsumi E; McClain K; et al
This case report describes new manifestations of the acquired immune deficiency syndrome (AIDS) in a promiscuous homosexual man. Investigation of upper gastrointestinal bleeding in the patient lead to discovery of a high-grade, small, noncleaved cell (Burkitt-like) gastroduodenal lymphoma with visceral and extralympha
Ann Intern Med. 1985 Jan;102(1):1-7. Unique Identifier : AIDSLINE MED/85095304
Jones JF; Ray CG; Minnich LL; Hicks MJ; Kibler R; Lucas DO
Forty-four patients, including 26 adults and 18 children under 15 years of age, were referred for evaluation of recurrent or persistent illnesses, with symptoms including pharyngitis, lymphadenopathy, fever, headaches, arthralgia, fatigue, depression, dyslogia, and myalgia. Thirty-nine patients were positive for Epste
A 24-year-old woman developed the acquired immunodeficiency syndrome with lymphadenopathy, oral candidiasis, and Kaposi s sarcoma. Her only known risk factor for the syndrome was sexual contact with an asymptomatic Haitian man. The woman had serologic evidence for infection with human T-cell lymphotropic virus type II
Ann Intern Med. 1985 Feb;102(2):200-2. Unique Identifier : AIDSLINE MED/85095359
Mintzer DM; Real FX; Jovino L; Krown SE
Kaposi s sarcoma occurs in about one third of patients with the acquired immunodeficiency syndrome. Although in some patients the tumor is principally a cosmetic problem, other patients have progressive disease with significant morbidity. Twenty-three patients with Kaposi s sarcoma related to the acquired immunodefici
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