A 73-year-old man developed Kaposi s sarcoma 6 years after the diagnosis of hairy-cell leukemia, at which time a splenectomy was performed. He received no additional treatment. The Kaposi s sarcoma was complicated by the development of immune thrombocytopenia and Listeria monocytogenes meningitis. Evaluation during th
A 40-year-old bisexual man with the acquired immunodeficiency syndrome developed abdominal pain and bloody diarrhea. At sigmoidoscopy, the mucosa of the rectum and sigmoid colon was edematous, erythematous, and friable, with multiple linear and oval erosions. Histologic examination of rectal biopsies demonstrated innu
In this paper, I have focused on the issue of the clinical gastroenterologist who refuses to evaluate and endoscope the patient with AIDS. The discussion centers around the legal and ethical properties of such a decision, and the legal doctrine of abandonment. Finally, I have reviewed recent recommendations regarding
Using electrophysiological techniques, the present study demonstrated that substantial direct somatosensory cortical influences on the superior colliculus (SC) originate from three areas: a) SIV, b) para-SIV (the cortex adjacent to SIV but deeper in the anterior ectosylvian sulcus (AES) and for which no topography has
Since August 25, 1981, an outbreak of simian acquired immunodeficiency syndrome ( SAIDS ) has been recognized in a single outdoor corral housing 77 rhesus monkeys (Macaca mulatta) over a 16-month period. The etiology of this syndrome is unknown but epidemiologic evidence suggests an infectious agent. Thirty-two cases
Med Hypotheses. 1984 Apr;13(4):395-7. Unique Identifier : AIDSLINE MED/84218958
de Long R
An hypothesis is proposed to explain the surge of new diseases appearing in the world. Mass immunization with live viral vaccines increases the probability of genetic recombination between live vaccine viruses and between live vaccine viruses and other viruses. Perhaps this is the reason for origination of new disease
Clinical course and laboratory data of three patients with sinus histiocytosis and massive lymphadenopathy ( SHML ) are described. In 80% of the cases a massive and painless bilateral enlargement of the cervical lymphnodes is the presenting feature; 25% show extranodal involvement. The etiology of SHML is as yet unkno
Z Hautkr. 1984 Apr 15;59(8):502-6. Unique Identifier : AIDSLINE MED/84226338
Scheier R
The safety of the hepatitis B vaccine H-B- Vax derives from a very strict screening of plasma donors as well as an extensive production process consisting of several purification and three inactivation steps. During a follow up of about 20 000 vaccine recipients over a 7 year-period, no known occurrence of AIDS or oth
There have been no documented cases of acquired immunodeficiency syndrome (AIDS) in personnel after a prospectively recognized in-hospital blood exposure. To assess the frequency of such exposure the membership of the Association for Practitioners in Infection Control was surveyed in early June 1983. Thirty-three perc
Seemayer TA; Laroche AC; Russo P; Malebranche R; Arnoux E; Guerin JM; Pierre G; Dupuy JM; Gartner JG; Lapp WS; et al
Thymuses from six heterosexual Haitian patients with the acquired immune deficiency syndrome (AIDS) were studied by light microscopy and the findings were compared with those from three control groups. The control groups included 1) five age-matched Haitian hospital patients; 2) ten age- and sex-matched Montreal patie
Antilymphocyte antibodies were studied using the Terasaki microcytotoxicity technique in 21 gay patients including 7 with Kaposi s sarcoma, 5 with opportunistic infection, and 9 with lymphadenopathy syndrome. A significant increase in lymphocyte-reactive antibody was noted in 61% of this group. Similar studies using s
The authors present the cases of nine patients with acquired immunodeficiency syndrome (AIDS) and intracerebral mass lesions, who were evaluated at the University of California, San Francisco, between April, 1979, and July, 1983. Eight patients were confirmed homosexual males, and none was Haitian . Their average age
Fifty-two patients with pulmonary complications of acquired immunodeficiency syndrome (AIDS) were studied over a 3-year period. The vast majority of the patients were homosexual; however, a significant number were intravenous drug abusers. Thirteen different organisms were noted, of which Pneumocystis carinii was by f
To assess the sensitivity of bronchoalveolar lavage in patients with the acquired immunodeficiency syndrome (AIDS) in diagnosing Pneumocystis carinii pneumonia (PCP), we prospectively performed 27 bronchoalveolar lavages (BAL) in 16 patients either because there was an initially high index of suspicion of PCP or in or
deShazo RD; Penico JP; Pankey GA; Nordberg JA; Newton JL; Bozelka B; Cortez LM; Dalovisio JR
We studied the immunologic function of 19 sexually active homosexual men, ten of whom had persistent lymphadenopathy. Analysis of mononuclear cell populations distinguished homosexuals from heterosexual controls since, as a group, homosexuals had increased percentages of natural killer cells (Leu 7+), decreased helper
Layon J; Idris A; Warzynski M; Sherer R; Brauner D; Patch O; McCulley D; Orris P
Baseline immunologic abnormalities were identified in 16 hospitalized intravenous drug abusers ( IDAs ) without acquired immune deficiency syndrome (AIDS). Twelve (75%) of 16 had inverted helper-suppressor ratios. In seven patients (44%), the abnormal ratio resulted from an increase in the absolute number of suppresso
Ann Dermatol Venereol. 1984;111(1):11-23. Unique Identifier : AIDSLINE MED/84229736
Janier M; Perroud AM; Revuz J; Wechsler J; Feuilhade M; Poirier J; Caron JP; Touraine R
We report a new case of acquired immune-deficiency syndrome (AIDS) in a 43 year-old white homosexual man, characterized by the association of disseminated cutaneo-mucous Kaposi s sarcoma and cerebral toxoplasmosis. This man had Kaposi s sarcoma for about 10 years but evolution became quickly extensive in July 1981. Ch
Bertotto A; Rambotti A; Gentilini F; Stefanelli M; Zucchetti P; Vaccaro R
Viral infections are often associated with immunodeficiency states. Although T lymphocytes have been thought to suppress the host s immune response, the precise cellular basis for this phenomenon remains unclear. Therefore, we characterized peripheral blood mononuclear cells from 9 measles virus-infected children by m
Mod Vet Pract. 1984 Mar;65(3):204-9. Unique Identifier : AIDSLINE MED/84219361
Pearson EG
Cattle with Pasteurella bronchopneumonia usually have a fever, abnormal respiratory sounds in the cranioventral lung fields, consolidation, pleuritis and abscesses. Lungworms primarily affect 4- to 6-month-old calves, which become febrile and dyspneic, with moist rales. Diagnosis is by fecal examination using the Baer
Z Hautkr. 1984 Apr 15;59(8):507-22. Unique Identifier : AIDSLINE MED/84226339
Krueger GR; Papadakis T; Michel R
Data from morphologic and immunologic follow-up studies are presented of ten patients with AIDS. The sequence of morphologic lesions in lymph nodes proceeds from an initial marked hyperplasia of T- and B-zones (follicular hyperplasia with plasmacytosis and diffuse paracortical hyperplasia) to paracortical atrophy with
Unzeitig JC; Church JA; Gomperts ED; Nye CA; Pasquale S; Richards W
The acquired immune deficiency syndrome (AIDS) has been reported in hemophiliacs . We examined lymphocyte numbers and functions in 28 patients with hemophilia and 16 healthy adults. Healthy hemophiliacs who had received fewer than 150 commercial factor concentrate (CFC) infusions had normal T-cell numbers, T-cell subs
A T-cell (KH-2) from a Japanese T-cell leukemia patient with hypercalcemia has been characterized and shown to be similar in its properties to Human T-cell leukemia virus (HTLV)-positive T-cell lines from T-cell leukemia patients from different parts of the world. The HTLV isolated from the Japanese T-cell leukemia pa
Cancer Res. 1984 Jul;44(7):2743-9. Unique Identifier : AIDSLINE MED/84205431
Gallo RC; Wong-Staal F
The study of retroviruses now has direct relevance to the understanding of tumorigenesis in humans. This came about through direct demonstration of retroviruses as etiological agents in certain human tumors and through the discovery of a set of cellular genes (onc genes) that may play important roles in normal and abn
The simian sarcoma virus transforming gene, v-sis, encodes a protein, p28sis , that is closely related to human platelet-derived growth factor (PDGF). The human locus related to v-sis was cloned and shown to contain at least five exons corresponding to the v-sis coding region. Nucleotide sequence analysis of these exo
Platelet-derived growth factor (PDGF) is a basic (pI congruent to 10) 30 000 molecular weight protein circulating in normal blood sequestered within the platelet alpha-granules. It binds with high affinity (Kd = 10(-11) M) to a specific cell-surface receptor found on many connective tissue cell types in culture. It is
Adult T cell leukemia (ATL) and Sezary leukemia are malignant proliferations of T lymphocytes that share similar cell morphology and clinical features. ATL is associated with HTLV (human T cell leukemia/lymphoma virus), a unique human type C retrovirus, whereas most patients with the Sezary syndrome do not have antibo
A mouse hybridoma cell line producing monoclonal antibody, F10, was established from mice hyperimmunized with cells bearing adult T cell leukemia (ATL) virus (ATLV). F10 antibody reacted with an ATLV structural polypeptide ( gp21 ) with a m.w. of 21,000 that was glycosylated on cell surfaces. The gp21 was expressed on
Utilizing the principles of counterimmunoelectrophoresis, a technique was devised to immunologically identify non-denatured protein antigens resolved by polyacrylamide gel electrophoresis. Proteins were electrophoretically transferred from polyacrylamide gel to antibody-containing agarose gel in a commercially availab
Quinnan GV Jr; Masur H; Rook AH; Armstrong G; Frederick WR; Epstein J; Manischewitz JF; Macher AM; Jackson L; Ames J; et al
Herpesvirus infections were studied in persons with or at risk for the acquired immune deficiency syndrome (AIDS). The infections diagnosed were as follows: patients with AIDS, cytomegalovirus ( CMV ) in 34 of 34, Epstein-Barr
One hundred hemophiliacs were studied for serological evidence of infection with cytomegalovirus ( CMV ), Epstein-Barr virus (EBV), and hepatitis B virus. Ninety-eight percent had markers of hepatitis B infection, while 69% had
A syndrome of acquired immunodeficiency has been identified in a group of rhesus monkeys (Macaca mulatta) which died at the California Primate Research Center. Clinical evaluation of these animals revealed that 50% or more had lymphadenopathy, weight loss, and diarrhea. At least 30% had splenomegaly, fever, cutaneous
Nature. 1984 Jun 14-20;309(5969):640-2. Unique Identifier : AIDSLINE MED/84219779
Seiki M; Eddy R; Shows TB; Yoshida M
Human T-cell leukaemia virus (HTLV), previously also reported as ATLV, is a recently identified retrovirus which is closely associated with adult T-cell leukaemia (ATL) endemic in southwestern Japan and the Caribbean. Determination of the total nucleotide sequence of the HTLV genome
Proc Natl Acad Sci U S A. 1984 Jun;81(12):3856-60. Unique Identifier : AIDSLINE MED/84222055
Lee TH; Coligan JE; Homma T; McLane MF; Tachibana N; Essex M
Specific antibodies to cell membrane antigens found on human T-cell leukemia virus (HTLV)-infected cells have been detected in Japanese patients with adult T-cell leukemia/lymphoma and in asymptomatic carriers, using a live cell-membrane immunofluorescence assay. Reactivity of the positive antisera was analyzed using
Normal rat kidney (NRK) cells transformed by simian sarcoma virus (SSV) release into the culture medium a biologically active mitogen with properties identical to those of human platelet-derived growth factor (PDGF). Like PDGF, the growth factor derived from SSV-NRK cells was shown to be stable to heat and sensitive t
Lymphadenopathy associated virus ( LAV ) has been isolated from patients with the acquired immunodeficiency syndrome (AIDS) or lymphadenopathy syndrome. Since the immune deficiency in AIDS seems to be primarily related to the defect of the helper-inducer T lymphocyte subset, the possibility that LAV is selectively tro
A strain of lymphadenopathy associated retrovirus ( LAV ) passaged in vitro was used to infect a lymphoblastoid cell line obtained by transformation with Epstein-Barr virus of B lymphocytes from a healthy donor. The virus produced from this line (B- LAV ) was also able to grow at a high rate in some other lymphoblasto
Supernatants derived from peripheral blood mononuclear cell cultures of certain patients with the acquired immunodeficiency syndrome (AIDS) or its prodromes have the capacity to block T cell-dependent immune reactivity in vitro. T cells derived from a patient positive for antibody to the lymphadenopathy associated vir
Feorino PM; Kalyanaraman VS; Haverkos HW; Cabradilla CD; Warfield DT; Jaffe HW; Harrison AK; Gottlieb MS; Goldfinger D; Chermann JC; et al
A retrovirus isolated from three patients with the acquired immunodeficiency syndrome (AIDS) in the United States was morphologically and antigenically identical to lymphadenopathy associated virus isolated in France . Two of these isolates were from
Vet Pathol. 1984 Mar;21(2):208-15. Unique Identifier : AIDSLINE MED/84225604
Hall GA; Bridger JC; Brooker BE; Parsons KR; Ormerod E
Fourteen gnotobiotic calves were killed 0.5 to ten days after infection with Newbury agent SRV-1 and the changes in small intestinal structure and function were assessed, qualitatively and quantitatively, by light microscopy, scanning and transmission electron microscopy, enzymology and xylose absorption. The first en
Clarke MF; Trainor CD; Mann DL; Gallo RC; Reitz MS
Leukemic peripheral blood lymphocytes from individuals infected with the human T-cell leukemia/lymphoma virus (HTLV) were found to express little or no viral RNA before being put into tissue culture. Within 24-48 hr, viral RNA expression increased at least four- to eightfold. Established HTLV-infected cell lines const
Possible transmission of adult T cell leukemia virus (ATLV) by blood transfusion was studied retrospectively. Of 41 recipients of whole blood or blood components containing cells from donors having antibodies to antigen that is associated with ATLV (anti-ATLA), 26 (63.4%) produced anti-ATLA. However, no anti-ATLA was
A well-documented case of cytomegalovirus- and Cryptosporidium-associated cholecystitis is described in a 19-year-old heterosexual Haitian man who had the acquired immune deficiency syndrome and acute acalculous gangrenous cholecystitis associated with these pathogens. This case adds to the spectrum of the manifestati
Ann Neurol. 1984 May;15(5):502-5. Unique Identifier : AIDSLINE MED/84229921
Horoupian DS; Pick P; Spigland I; Smith P; Portenoy R; Katzman R; Cho S
A 35-year-old homosexual man with acquired immune deficiency syndrome developed progressive dementia and spastic quadriparesis over a two-month period. Severe symmetrical, bilateral degeneration of the corticospinal and frontopontine fibers and cerebellar white matter were found po
We described here the characteristics of the Reverse Transcriptase activity associated with the Lymphadenopathy Associated Virus ( LAV ). A critical concentration of non ionic detergent, all four deoxyribonucleosides triphosphates and the divalent cation Mg2+ are required for optimal endogenous enzyme activity. The en
In early 1981 several cases of Pneumocystis carinii pneumonia in young male homosexuals were recognized. Between then and the end of 1982 almost 800 cases of serious opportunistic infections and malignancies have occurred in this group and now in other groups as well. The most common malignant disease to be seen is th
A network of idiotypic and anti-idiotypic antibodies is often suggested as the basis for cellular interactions that maintain a steady-state immunological equilibrium. This hypothesis proposes that repeated exposure to certain external antigens--ie, both viral and sperm--stimulates an unregulated production of a unique
IgG antibodies to lymphadenopathy-associated virus ( LAV ) were found by a specific enzyme-linked immunosorbent assay in 18/48 (37.5%), patients with acquired immunodeficiency syndrome, 38/51 (74.5%) patients with lymphadenopathy syndrome, 8/44 (18%) homosexual men without lymphadenopathy, and 1/100 unselected blood d
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