Immunoglobulin D (IgD) was determined by double diffusion in the serum from 26 patients with endocrine disorders and diseases of immune imbalance along with controls. IgD was detected in the serum of nine patients that included two with primary parathyroidism, one with insulin-resistant diabetes, four with immunodefic
Gardenswartz MH; Lerner CW; Seligson GR; Zabetakis PM; Rotterdam H; Tapper ML; Michelis MF; Bruno MS
To determine the nature and frequency of renal disorders in AIDS we reviewed the records of thirty-two patients hospitalized over a twenty-two month period. Group I, including all patients with AIDS who demonstrated proteinuria and/or renal insufficiency, numbered thirteen patients, in ten of whom renal tissue was ava
A case of Mycobacterium xenopi infection in a patient with acquired immunodeficiency syndrome (AIDS) is described and the clinical experience of others in the United States with this organism is reviewed. Disseminated infection by this organism appears to occur only in the immunocompro
The ipsilateral corticocortical connections of the second and fourth somatic sensory areas (SII and SIV) were traced with the aid of anterograde or retrograde axonal transport techniques involving horseradish peroxidase conjugated to wheat germ agglutinin (HRP-WGA) or tritiated amino acids. The injections were placed
N Engl J Med. 1984 Aug 9;311(6):354-8. Unique Identifier : AIDSLINE MED/84245744
Klein RS; Harris CA; Small CB; Moll B; Lesser M; Friedland GH
We studied the frequency with which unexplained oral candidiasis led to unequivocal acquired immunodeficiency syndrome (AIDS) in patients at risk. Twenty-two previously healthy adults with unexplained oral candidiasis, of whom the 19 tested had a reversed T4/T8 ratio and 20 had generalized lymphadenopathy, were compar
Although the pathophysiology of acquired immune deficiency syndrome (AIDS) is not completely understood, we know a great deal about its epidemiology, risk factors, clinical manifestations, course, and immunologic features. Clinicians caring for high-risk individuals, particularly those in endemic urban areas, should r
Progressive multifocal leukoencephalopathy (PML) occurred in a heterosexual Haitian man with acquired immune deficiency syndrome (AIDS). The patient initially had focal neurologic signs and nonenhancing lesions on a computed tomographic scan. Although PML is rare, it should be included in the differential diagnosis of
Int Dent J. 1984 Jun;34(2):127-9. Unique Identifier : AIDSLINE MED/84238425
Mitchell EW
A vaccine for type B (serum) hepatitis is available for individuals at high risk of acquiring the disease. The high-risk status of dental personnel to type B hepatitis is discussed. The safety and efficacy of the vaccine, its limitations relative to other types of hepatitis, and its role in preventing the disease are
Prince HE; Schroff RW; Ayoub G; Han S; Gottlieb MS; Fahey JL
To investigate the possible contribution of genetic susceptibility to Kaposi s sarcoma associated with acquired immune deficiency syndrome (AIDS-KS), 21 patients were typed for HLA-A, B, C, and DR antigens. Significantly increased frequencies of HLA-Aw23, and HLA-Bw49 antigens were observed in the Caucasian AIDS-KS gr
The incidence of Kaposi s sarcoma (KS) was examined with the use of data from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. KS is a manifestation of the recent epidemic of acquired immunodeficiency syndrome (AIDS) that has occurred particularly among homosexual men. T
On the basis of the 6 cases reported here and scattered published cases, the existence of a childhood chronic immunoblastic lymphadenopathy syndrome is proposed. It is characterized by the following features: A systemic immunoblastic proliferation with varying degrees of maturation resembling the B lymphocyte hyperimm
JAMA. 1984 Aug 3;252(5):639-44. Unique Identifier : AIDSLINE MED/84243112
Thomas PA; Jaffe HW; Spira TJ; Reiss R; Guerrero IC; Auerbach D
From Oct 1, 1982, to Oct 1, 1983, the Centers for Disease Control (CDC) received reports of 35 children whose illness met the CDC definition of acquired immune deficiency syndrome (AIDS). All of the children had serious opportunistic infections without a known underlying illness to explain susceptibility to the infect
Lymph nodes from macaque monkeys with an immunodeficiency syndrome were examined by electron microscopy and both routine histologic and immunoperoxidase staining techniques, using monoclonal antibodies that recognize specific primate lymphocyte subsets. In the early stages of disease, marked follicular hyperplasia and
A 6-month-old male infant with a severe combined immunodeficiency syndrome was hospitalized for progressive respiratory distress. Examination during hospitalization disclosed widespread pulmonary infiltrates that did not respond to intensive therapy. The patient died eight days after admission. Autopsy disclosed Pneum
Cole EL; Meisler DM; Calabrese LH; Holland GN; Mondino BJ; Conant MA
Acquired immune deficiency syndrome (AIDS) is a recently recognized disease characterized by abnormalities in cell-mediated immunity that predispose affected persons to severe opportunistic infections and unusual malignant neoplasms. We describe four cases of herpes zoster ophthalmicus in four previously healthy homos
Grieco MH; Reddy MM; Kothari HB; Lange M; Buimovici-Klein E; William D
beta 2-Microglobulin (beta 2-M) levels in sera and urines, and lysozyme levels in sera, were quantitated in healthy heterosexual men and several groups of homosexual males. The mean beta 2-M levels in sera and urines and lysozyme levels in sera of healthy heterosexual and homosexual men were not significantly differen
Neurotropic viruses cause a number of important infectious syndromes including encephalitis, myelitis, meningitis, and radiculopathy. In this review, the biology of conventional and unconventional viruses is examined. The host immune response to viruses is discussed, and patterns of viral pathogenesis are explained. T
South Med J. 1984 Jul;77(7):927-8. Unique Identifier : AIDSLINE MED/84250367
Costel EE; Wheeler AP; Gregg CR
Acute gangrenous cholecystitis and relapsing bacteremia caused by Campylobacter fetus ssp fetus occurred in a patient with acquired immunodeficiency syndrome. Biliary tract colonization probably accounted in part for this unusual phenomenon. Whether the patient s deficiency of cell-mediated immunity contributed to his
Ann Intern Med. 1984 Aug;101(2):202-4. Unique Identifier : AIDSLINE MED/84254900
Portnoy D; Whiteside ME; Buckley E 3d; MacLeod CL
Nine male patients with the acquired immunodeficiency syndrome and one female patient who had an allogeneic bone marrow transplant for acute myeloblastic leukemia in relapse developed severe debilitating diarrhea. Cryptosporidium species were found in the stools of all patients. After receiving treatment with spiramyc
A 25-year-old man with hemophilia who had been treated primarily with cryoprecipitate presented with epigastric pain and loose, melenic stools. He had a long history of malaise and intermittent upper respiratory tract infection with fever. The patient was shown to have disseminated histoplasmosis and refractory herpes
Ceuppens JL; Vermylen J; Colaert J; Desmyter J; Gautama K; Stevens E; The AL; Vanham G; Vermylen C; Verstraete M
We studied immune function in Belgian haemophiliacs treated with Factor VIII from volunteer donors. No patient had clinical evidence of immune deficiency. We found a decrease in T-helper cells (p less than 0.0005), in the ratio of T-helper over T-cytotoxic/suppressor cells (1.72 +/- 0.47 versus 2.24 +/- 0.82 in contro
Boll Ist Sieroter Milan. 1983;62(6):517-23. Unique Identifier : AIDSLINE MED/84231706
Brugo MA; Guffanti A; Guzzetti S; Pedretti D; Stringhetti M; Confalonieri F
An assessment of T-lymphocyte populations was performed in two groups of drug addicts by the technique of monoclonal antibodies. Group I was composed of 11 asymptomatic heroin addicts, group II being in heroin withdrawal program from at least six months. Homosexual subjects, partners of patients with AIDS and patients
Reversed T-helper/T-suppressor ratios were found in 20/43 symptomatic homosexual men. A significant lower number of T-helper cells was found in patients with skin anergy. No differences were noticed in total lymphocytes or in any of the other T-cell subsets, when subjects with and without skin anergy or lymphadenopath
EMBO J. 1982;1(9):1029-33. Unique Identifier : AIDSLINE MED/84236080
Born M; von der Helm K; Deinhardt F
Cells transformed by simian sarcoma virus (SSV) express a 115000-dalton protein ( p115 ) that is precipitated by a goat antiserum to disrupted SSV/SSAV-infected and transformed cells but not by antibodies directed against the viral gag protein, p30, or envelope proteins. The protein is detected in productively as well
The relationship between platelet-derived growth factor (PDGF) and the proto-oncogene c-sis has been determined by amino acid sequence analysis of PDGF and nucleotide sequence analysis of c-sis genomic clones. The nucleotide sequences of five regions of the human c-sis gene which are homologous to sequences of the tra
The expression of adult T-cell leukemia virus (ATLV/HTLV) antigen was demonstrated by the indirect immunofluorescence method in phytohemagglutinin-cultured mononuclear cells of milk samples from 3 out of 22 sero-positive mothers after delivery. This result raises the possibility that milk might be the source of ATLV/H
Hayami M; Tsujimoto H; Komuro A; Hinuma Y; Fujiwara K
Transmission of adult T-cell leukemia virus (ATLV) was demonstrated from human lymphoid cell lines carrying ATLV to various non-lymphoid cells accompanied with syncytium formation, which was specifically inhibited by human anti-ATLV sera, indicating that ATLV has cell membrane fusion activity.
After decades of work, a retrovirus of true human origin has been isolated first from a U.S. adult case of T-cell lymphoma and then from cases from various regions of the world. This virus, named HTLV-I, is strongly associated with a malignant leukemia-lymphoma of mature T-cells. This disease was first clinically char
Int J Cancer. 1984 Jun 15;33(6):717-20. Unique Identifier : AIDSLINE MED/84238498
Maeda Y; Furukawa M; Takehara Y; Yoshimura K; Miyamoto K; Matsuura T; Morishima Y; Tajima K; Okochi K; Hinuma Y
A nation-wide survey of carriers of adult T-cell leukemia virus (ATLV) detected as anti-ATLA (ATLV-associated antigens) in volunteer blood donors was made in Japan . A total of 200 sera from donors between 40 and 64 years of age, collected in each of 64 blood centers located in eight
Int J Cancer. 1984 Jun 15;33(6):745-9. Unique Identifier : AIDSLINE MED/84238502
Yoshikura H; Nishida J; Yoshida M; Kitamura Y; Takaku F; Ikeda S
HTLV was isolated in the human diploid fibroblast strain IMR90 directly from the leukemic cells of the Japanese ATL-patients. The infection was checked by the presence of virus-specific p24 and proviral DNA. The isolation was successful in three of four patients. The patient whose virus isolation was unsuccessful cont
Int J Cancer. 1984 Jun 15;33(6):795-806. Unique Identifier : AIDSLINE MED/84238510
Greaves MF; Verbi W; Tilley R; Lister TA; Habeshaw J; Guo HG; Trainor CD; Robert-Guroff M; Blattner W; Reitz M; et al
Ten out of 26 leukaemic patients who had emigrated from the Caribbean region to the United Kingdom had adult T-cell leukaemia with associated serum antibodies to HTLV I. Antibodies to HTLV were also detected in sera from a small proportion of non-leukaemic Caribbean immigrants but not
Kannagi M; Sugamura K; Kinoshita K; Uchino H; Hinuma Y
Cytotoxic T cells (Tc) derived from one patient with adult T cell leukemia/lymphoma (ATL) killed fresh autologous lymphoma cells in vitro. The Tc were induced from peripheral blood leukocytes (PBL) of this patient during remission by multiple in vitro stimulations with an autologous ATLV-bearing cell line (ILT) that w
The acquired immune deficiency syndrome (AIDS) appeared in the United States in late 1978 and has spread at an epidemic rate through the four major coastal cities of this country. The disease appears to show the same epidemiologic distribution as hepatitis B virus infection, and for th
We describe previously published work as well as new data on the molecular biology of human T-cell leukemia virus (HTLV) and its associated disease, adult T-cell leukemia-lymphoma (ATLL). This specific kind of disease is endemic to certain areas of Japan and the Caribbean, and sever
Med Trop (Mars). 1984 Jan-Mar;44(1):9-15. Unique Identifier : AIDSLINE MED/84245099
Coulaud JP; Saimot AG; Charmot G
In the temperate climate countries, AIDS is defined as the occurrence of opportunistic infections and/or Kaposi s sarcoma in adults, mostly homosexuals. It can be preceded by a related state of asthenia, loss of weight, adenopathies, diarrhoea, but which is far from always developing into AIDS. The immune syndrome is
Rodrigues MM; Palestine A; Nussenblatt R; Masur H; Macher AM
A 42-year-old bisexual man with the acquired immunodeficiency syndrome, cryptococcal meningitis, disseminated Mycobacterium avium-intracellulare with mycobacteremia, and oropharyngeal candidiasis developed unilateral retinitis and bilateral cotton wool patches. Histopathologic examination revealed unilateral necrotizi
The human immune system has evolved multiple cellular and humoral defense mechanisms against the lymphotropic virus, EBV. NK cells, suppressor T-cells, cytotoxic K-cells, memory T-cells, and humoral immune responses usually subdue the virus into latency. Individuals with immune deficiency are at great risk of developi
We previously reported the sequence of the gene for human interleukin 2 ( IL-2 ) which included about 220 b.p. of the 5 flanking region. In this report we have extended the 5 sequence to 1263 b.p. before the start site of transcription and have compared the entire sequ
Proc Natl Acad Sci U S A. 1984 Jul;81(13):4080-4. Unique Identifier : AIDSLINE MED/84248062
Koeffler HP; Ranyard J; Yelton L; Billing R; Bohman R
Gamma-Interferon (IFN-gamma) is a lymphokine produced by T lymphocytes. We find that recombinant human IFN-gamma induces expression of HLA-D antigens on human promyelocytic leukemia cells (HL-60) and enhances expression of HLA-D antigens on normal human monocytes and macrophages. Induction of both HLA-D antigen expres
Lymphadenopathy-associated virus ( LAV ), a human T- lymphotrophic retrovirus isolated from a homosexual man with lymphadenopathy, has been causally associated with acquired immunodeficiency syndrome (AIDS). A sensitive and specific radioimmunoprecipitation test was developed for the detection of antibodies to the maj
The transcription initiation signals for retroviruses lie within the long terminal repeat (LTR) sequences that flank the integrated provirus. Two subtypes of human T lymphotropic virus (HTLV) are associated with different disease phenotypes. In this article it is shown that marked differences exist in the ability of L
The sequence of the 3 terminus of the human T lymphotropic virus type II (HTLV-II) was determined and compared to the corresponding sequence of HTLV-I. The 1557-nucleotide-long sequence can be divided into a 5 region that is not conserved between the two viruses, and a 3 , 1011-nucleotide-long region that is highly
Sodroski J; Patarca R; Perkins D; Briggs D; Lee TH; Essex M; Coligan J; Wong-Staal F; Gallo RC; Haseltine WA
The sequence of the envelope glycoprotein gene of type II human T lymphotropic virus (HTLV) is presented. The predicted amino acid sequence is similar to that of the corresponding protein of HTLV type I, in that the proteins share the same amino acids at 336 of 488 residues, and 68 of the 152 differences are of a cons
Lancet. 1984 Jun 23;1(8391):1383-5. Unique Identifier : AIDSLINE MED/84244669
Ellrodt A; Barre-Sinoussi F; Le Bras P; Nugeyre MT; Palazzo L; Rey F; Brun-Vezinet F; Rouzioux C; Segond P; Caquet R; et al
A Zairian married couple had been living in France since 1981. The man had acquired immunodeficiency syndrome (AIDS) and his wife had prodromes of the disorder. Infection with a human T-lymphotropic retrovirus (lymphadenopathy-associated virus) was demonstrated in both by isolation
Markers of the immune system were examined in 47 patients with haemophilia A and B who had been treated exclusively with blood products from a population apparently free from acquired immunodeficiency syndrome (AIDS). In haemophilia A the absolute number of T helper cells was depressed, resulting in a reduction in the
In a double-blind study, sera of 34 patients with acquired immunodeficiency syndrome (AIDS), 19 patients with lymphadenopathy syndrome, and 14 homosexual men with an increased risk of AIDS were screened for antibodies to proteins of the novel human T-lymphotropic retrovirus (leukaemia virus), HTLV-III, recently isolat
Lancet. 1984 Jun 30;1(8392):1452-5. Unique Identifier : AIDSLINE MED/84244722
Bloom AL
A questionnaire concerning the occurrence of acquired immunodeficiency syndrome (AIDS) and possible related clinical syndromes in treated haemophiliacs was sent to directors of 201 European haemophilia centres. 135 replies were received from eighteen countries, covering 8928 patients with haemophilia A, 1889 with haem
Van de Perre P; Rouvroy D; Lepage P; Bogaerts J; Kestelyn P; Kayihigi J; Hekker AC; Butzler JP; Clumeck N
To evaluate acquired immunodeficiency syndrome (AIDS) in central Africa a prospective study was done in Kigali, Rwanda , where Kaposi s sarcoma (KS) is endemic. During a 4 week period, 26 patients (17 males and 9 females) were diagnosed. 16 patients had opportunistic infections, ass
38 patients with the acquired immunodeficiency syndrome (AIDS) were identified in Kinshasa, Zaire , during a 3 week period in 1983. The male to female ratio was 1.1:1. The annual case rate for Kinshasa was estimated to be at least 17 per 100 000. Opportunistic infections were diagn
Tedder RS; Shanson DC; Jeffries DJ; Cheingsong-Popov R; Clapham P; Dalgleish A; Nagy K; Weiss RA
Antibodies reacting selectively with human T-cell leukaemia virus type I (HTLV-I) were detected in approximately 5% patients with extended lymphadenopathy syndrome (ELAS) and in less than 1% of unselected homosexual patients and drug abusers. None of 22 patients with acquired immunodeficiency syndrome (AIDS) had HTLV-
Robert-Guroff M; Blayney DW; Safai B; Lange M; Gelmann EP; Gutterman JW; Mansell PW; Goedert JL; Groopman JE; Steigbigel NH; et al
Serum samples from 440 acquired immunodeficiency syndrome (AIDS) patients or individuals at risk for AIDS were examined by the enzyme-linked immunosorbent assay technique for antibodies to HTLV-I core proteins. Specific antibodies were detected in 7% of AIDS patients, 7% of patients with lymphadenopathy, 0% of healthy
Cysteamine given three times within 8 h produced severe duodenal and gastric ulcers in female SIV rats. A pentobarbital anesthesia during the first 10 h prevented gastric ulcer formation without affecting duodenal ulcer. An additional 10 h lasting intragastric infusion with 0.6 ml/h Ringer containing 5 mmol/l of a mix
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