Porzsolt F; Hauser M; Piper C; Scholz S; Stotter H; Pindur G; Seifried E; Rasche H
In the present study, 28 hemophiliacs substituted continuously and 5 hemophiliacs who had received almost no blood products were investigated. Cells of OKT 3+, OKT 4+, and OKT 8+ subsets were counted. Percoll separated fractions of peripheral blood mononuclear cells were examined by morphological criteria and were tes
Weber JN; Carmichael DJ; Sawyer N; Pinching AJ; Harris JR
Between August and November 1983, seven new patients with AIDS were seen at this hospital; two with disseminated Kaposi s sarcoma, and five with opportunist infections, of whom three have died. We present the case histories of the five patients with opportunist infections, which show the wide clinical range of AIDS an
Berlin OG; Zakowski P; Bruckner DA; Clancy MN; Johnson BL Jr
Mycobacterium avium complex has been isolated with increasing frequency from humans during the last few decades. Thirteen patients admitted to the UCLA Medical Center with the diagnosis of acquired immunodeficiency syndrome (AIDS), in addition to having Kaposi s sarcoma, Pneumocystis pneumonia, and other opportunistic
An epidemic of cases of toxoplasmic encephalitis is occurring in patients with acquired immune deficiency syndrome (AIDS). Serological or histopathologic studies were performed on 70 cases with AIDS and toxoplasmic encephalitis. In many cases conventional stains of brain-tissue specimens failed to disclose Toxoplasma
JAMA. 1984 Aug 17;252(7):934-5. Unique Identifier : AIDSLINE MED/84268074
Cooper JS; Fried PR; Laubenstein LJ
Fifteen patients who had Kaposi s sarcoma in conjunction with the acquired immune deficiency syndrome (AIDS) received radiotherapy to a total of 17 selected lesions. All tumors exhibited at least partial regression, and the majority responded completely. The radiosensitivity of these lesions is similar to that observe
To determine if vesicular rosettes (VR), tubuloreticular structures (TRS), and test-tube and ring-shaped forms (TRF) are characteristic ultrastructural features of the syndromes of acquired immune deficiency (AIDS) or of unexplained persistent lymphadenopathy (PLS), the authors studied lymph nodes from nine patients w
Am J Med. 1984 Aug;77(2):224-8. Unique Identifier : AIDSLINE MED/84277749
Spivak JL; Bender BS; Quinn TC
Blood and marrow specimens were evaluated from 12 patients with the acquired immune deficiency syndrome (AIDS). Ten patients were anemic, eight leukopenic, and three thrombocytopenic. Pancytopenia was present in two patients and subsequently developed in two others. Reticulocyte counts were not increased in the anemic
South Med J. 1984 Aug;77(8):1041-3. Unique Identifier : AIDSLINE MED/84274514
England JD; Hsu CY; Garen PD; Goust JM; Biggs PJ
A 33-year-old homosexual man with symptoms and signs of a focal brain process was subsequently found to have an acquired immune deficiency syndrome (AIDS) with biopsy-proven progressive multifocal leukoencephalopathy. This report reemphasizes the association of progressive multifocal leukoencephalopathy with AIDS and
To determine whether healthy homosexual men are immunologically impaired, peripheral blood leukocytes (PBL) from 20 male homosexuals were compared prospectively with PBL from 14 age-matched male heterosexual donors with respect to: (a) the capacity of their PBL to generate functional T cell immune responses in vitro;
We describe the histologic and clinical features of non-Hodgkin s lymphoma diagnosed between January 1980 and December 1983 in 90 homosexual men from San Francisco, Los Angeles, Houston, and New York. The median age was 37 years, with an age distribution identical to that for cases
The immune response is a complex series of cellular interactions, which is controlled by several regulatory mechanisms to insure an appropriate response. One of the most important mechanisms of control is the suppressor T cell immunoregulatory circuit. The immune response is presented in detail and examined from three
Berk RN; Wall SD; McArdle CB; McCutchan JA; Clemett AR; Rosenblum JS; Premkumer A; Megibow AJ
Cryptosporidiosis is a parasitic disease of the gastrointestinal tract that causes a choleralike diarrhea in patients with the acquired immunodeficiency syndrome (AIDS). Review of barium studies of the stomach and small intestine in 16 AIDS patients with cryptosporidiosis showed that the studies were abnormal in 13. O
Can Med Assoc J. 1984 Aug 15;131(4):332-5. Unique Identifier : AIDSLINE MED/84258864
Ascah KJ; Hyland RH; Hutcheon MA; Urbanski SJ; Pruzanski W; St Louis EL; Jones DP; Keystone EC
A case of invasive aspergillosis complicated by the formation of an aspergilloma is described. The patient, a 48-year-old man, was apparently healthy except for mild alcoholic steatosis of the liver. A review of the literature revealed that 5 of the 14 previously reported cases of invasive aspergillosis in seemingly i
During a two-year period, two drug addicts and one homosexual patient with acquired immunodeficiency syndrome (AIDS) developed persistent Salmonella typhimurium or S. enteritidis bacteremia early in the course of their syndrome. A fourth patient, also a male homosexual with recurrent S. typhimurium bacteremia and urin
Plasma of a homosexual man with Kaposi s sarcoma and acquired immunodeficiency was perfused over a protein A column using a continuous-flow plasma-cell separator. Three liters of plasma was perfused during each procedure and returned to the patient at a plasma flow rate of 10-20 ml/min. Three treatments were performed
Med Clin North Am. 1984 May;68(3):741-56. Unique Identifier : AIDSLINE MED/84269382
Haller DG
The non-Hodgkin s lymphomas, although sharing a common origin, often present physicians with wide variations in natural history and prognosis. The proper therapy of these diseases is based on an understanding of these differences and upon the information gained by pathologic review and staging, as well as the availabl
A vasodestructive process has been identified within the placenta, which focuses on the entire placental vascular tree. Its presence is correlated with significant fetal mortality; liveborn infants are growth retarded and frequently in distress. Characteristic morphologic features have been identified in chorionic ves
Watanabe S; Reddy KR; Jeffers L; Dickinson GM; O'Connell M; Schiff ER
Characteristic pathological alterations of the liver in chimpanzees inoculated with non-A, non-B hepatitis sera have been described, but no corresponding findings have been reported in humans. Electron microscopic studies of the liver biopsy specimens of two homosexual patients with acquired immune deficiency syndrome
Intestinal infection by the coccidian parasite Cryptosporidium is a well-recognized condition in immunocompromised hosts and in some normal persons. The authors studied a patient with acquired immunodeficiency syndrome and cryptosporidiosis of the small intestine. The parasite inhabits the microvillous brush border of
Med Clin North Am. 1984 May;68(3):601-15. Unique Identifier : AIDSLINE MED/84269374
Gill FM
Treatment of hemophilia and von Willebrand s disease has become easier in recent years because of the development of more effective factor replacement products. The median age and the life expectancy of patients with hemophilia have risen markedly, as has the median age at death.
Patow CA; Steis R; Longo DL; Reichert CM; Findlay PA; Potter D; Masur H; Lane HC; Fauci AS; Macher AM
Since 1981 a new syndrome of acquired immune deficiency (AIDS) has been recognized. Male homosexuals, male and female intravenous drug abusers, and recipients of blood products (i.e., hemophiliacs) appear to be the populations at risk. The syndrome has been manifested by community-acquired opportunistic infections and
ITP in hemophiliacs may produce severe bleeding complications. We here report on an eight-year-old boy suffering from severe hemophilia A, who developed ITP and an acquired impaired immune function similar to AIDS. Steroid therapy reverted the thrombocyte count to normal, however it had to be discontinued because of a
Acquired immune deficiency syndrome (AIDS) is a new disease which has recently alerted the medical world. AIDS may also concern dental practitioners and oral surgeons who may be the first to suspect impairment of immunity in patients presenting opportunistic oral infections. Extraordinary resistance to treatment of de
Because interleukin 2 (IL 2) production and IL 2 receptor (IL 2R) expression are essential steps in T cell proliferation, we undertook to measure these parameters, as defects in one or both seemed likely to account for the reduced proliferative response to mitogen in acquired immune deficiency syndrome (AIDS) and lymp
Am J Hematol. 1984 Aug;17(2):167-76. Unique Identifier : AIDSLINE MED/84277679
Mannucci PM; Gringeri A; Ammassari M; Mari D
Eighty-three symptom-free hemophiliacs were studied clinically, serologically and by in vitro tests for cellular immunity in a geographical area in which AIDS has not yet been encountered despite the exclusive use of concentrates manufactured from American sources of plasma. Some patients showed the following abnormal
A man from Chile developed an aggressive mature T cell leukemia associated with marked eosinophilia. The neoplastic lymphocytes were of T helper surface phenotype, and they expressed the p24 and p19 antigens of human T cell leukemia virus (HTLV). A cell line (ME) was established fro
We studied the genomic structure of human T-cell leukemia virus (HTLV) in the HTLV producer cell line MT-2. Southern blotting revealed that at least eight HTLV proviruses were integrated in the chromosomes of MT-2 cells. The genomic structure of these proviruses was analyzed using fragments of cloned HTLV that were sp
For thr purpose of clarifing the role of cultured thymic epithelium (CTE) and dialyzable leukocyte extracts (DLE) in the maturation process of T cells, the effects of the thymic epithelial supernatant (TES) and DLE on cyclic nucleotides in thymocytes were studied. TES increased cAMP levels significantly in thymocytes
Necropsies were performed in 12 patients who fulfilled the Centers for Disease Control (CDC) criteria for acquired immunodeficiency syndrome (AIDS), and the postmortem findings were compared with the premortem diagnoses. All of the patients were men with a male sexual preference and histories of multiple episodes of v
Yamamoto N; Kobayashi N; Takeuchi K; Koyanagi Y; Hatanaka M; Hinuma Y; Chosa T; Schneider J; Hunsmann G
Eight lymphoblastoid cell lines were established from the peripheral blood of individual African green monkeys (AGM). The AGM-2206 line grew out spontaneously. The others - AGM-6, 7, 8, 10, 12, 13, and 16 - were obtained after infection of peripheral AGM lymphocytes with cell-free culture supernatant of AGM-2206. All
Peripheral blood lymphocytes (PBL) were obtained from five patients with the acquired immune deficiency syndrome (AIDS), six homosexual males with lymphadenopathy, and five normal heterosexual controls. Modulation of virus-specific immunity was assayed in vitro by measuring the lymphocyte blastogenic response and the
Lindmo T; Boven E; Cuttitta F; Fedorko J; Bunn PA Jr
Conjugates of monoclonal antibodies with radioactive isotopes, drugs or toxins have great potential for specific radiolocalization and inactivation of tumor cells. Because the conjugation procedure may adversely alter the antibody, quality control procedures must be applied to determine important characteristics of th
Vasily DB; Miller OF; Fudenberg HH; Goust JM; Wilson GB
Dialyzable leukocyte extracts (DLE) have been used to treat a variety of antigen selective, and broad spectrum immunodeficiency diseases with sometimes encouraging results. We describe here the clinical and laboratory responses to DLE therapy of 2 patients with epidermodysplasia verruciformis (EV), a chronic cutaneous
Robert-Guroff M; Coutinho RA; Zadelhoff AW; Vyth-Dreese FA; Rumke P
Sera of 98 participants in a methadone maintenance programme, all recent Surinam emigrants to the Netherlands , were examined for antibodies to disrupted HTLV using the ELISA technique. Twelve per cent of the donors possessed HTLV-specific antibodies with a range of titre from
Med Clin North Am. 1984 May;68(3):639-56. Unique Identifier : AIDSLINE MED/84269376
Dahlke MB
This article describes the characteristics of alloantibodies associated with accelerated in vivo red cell destruction, pretransfusion tests performed to detect these antibodies, and the resolution of the incompatible crossmatch. Current transfusion practices, the indications for, and the complications of red cell tran
Chosa T; Yamamoto N; Koyanagi Y; Kohno M; Nagata K; Hinuma Y
Adult T-cell leukemia-associated membrane antigen (ATLMA) expressed on the surface of living ATL virus (ATLV)-carrying cells was investigated by an indirect membrane immunofluorescence method using natural antibodies to ATLV in human sera. All the ATLV-positive cell lines tested that had cytoplasmic ATL-associated ant
Retroviruses isolated from avian, feline, murine and simian sources have been found to be inactivated and lysed by normal human serum. There is much evidence that complement is activated directly by retroviruses in the absence of antibody. Thus, human complement is thought to function as a natural defence mechanism ag
Nature. 1984 Aug 9-15;310(5977):505-6. Unique Identifier : AIDSLINE MED/84270731
Longo DL; Gelmann EP; Cossman J; Young RA; Gallo RC; O'Brien SJ; Matis LA
The human T-cell leukaemia/lymphoma virus (HTLV) is an exogenous retrovirus which has been associated with adult T-cell leukaemia/lymphoma (ATL). This malignancy of T lymphocytes is endemic to southern Japan , the West Indies, and to a lesser extent, the Middle East, Central Africa a
Human T-cell leukemia virus (HTLV) is a family of related human T-lymphotropic retroviruses closely linked with certain human T-cell malignancies and associated with many cases of acquired immunodeficiency syndrome (AIDS). We isolated and molecularly cloned HTLV from patients with both types of clinical disorders and
Proc Natl Acad Sci U S A. 1984 Aug;81(15):4617-21. Unique Identifier : AIDSLINE GENBANK/M19203
Sodroski J; Trus M; Perkins D; Patarca R; Wong-Staal F; Gelmann E; Gallo R; Haseltine WA
The majority of human T-cell leukemia virus isolates (HTLV-I) are associated with clinically aggressive adult T-cell leukemia/lymphomas. By contrast, HTLV-II has been isolated from a patient with a relatively benign hairy T-cell leukemia. To characterize differences in the viral genomes that might contribute to these
Proc Natl Acad Sci U S A. 1984 Aug;81(15):4741-5. Unique Identifier : AIDSLINE GENBANK/M19208
Sagata N; Yasunaga T; Ogawa Y; Tsuzuku-Kawamura J; Ikawa Y
The nucleotide sequence of the long terminal repeat (LTR) of bovine leukemia virus, a unique oncogenic retrovirus of cattle, was determined. The LTR consisted of 530 base pairs (bp) with an inverted repeat of 6 bp at its 5 and 3 ends, flanked by a direct repeat of 6 bp of host cell origin. A tRNAPro binding site for
Science. 1984 Aug 17;225(4663):716-8. Unique Identifier : AIDSLINE MED/84274417
Homma T; Kanki PJ; King NW Jr; Hunt RD; O'Connell MJ; Letvin NL; Daniel MD; Desrosiers RC; Yang CS; Essex M
Human T-cell leukemia virus has been linked with adult T-cell leukemia-lymphoma (ATLL), a tumor of mature T cells that occurs at elevated rates in southwestern Japan and in the Caribbean Basin. Human T-cell leukemia virus (HTLV) or a closely related virus, has also been found in var
S Afr Med J. 1984 Aug 11;66(6):226-9. Unique Identifier : AIDSLINE MED/84274726
Hayes MM; Coghlan PJ; King H; Close P
A patient in whom a single lymph node contained Kaposi s sarcoma, tuberculosis and Hodgkin s lymphoma is reported on. Kaposi s sarcoma was also present in the skin of the legs, and serum antibody titres to cytomegalovirus were elevated. This case may represent acquired immunodefici
Hattori S; Kiyokawa T; Imagawa K; Shimizu F; Hashimura E; Seiki M; Yoshida M
The gag and env gene products of human T-cell leukemia virus (HTLV) were identified with rabbit antisera against the synthetic peptides and a polypeptide produced in Escherichia coli, which corresponded to parts of the proteins predicted from the nucleotide sequence of HTLV [M. Seiki, S. Hattori, Y. Hirayama, and M. Y
The simian sarcoma virus transformation-specific glycopeptide (SSV-TrSgp) represents a proteoglycan which is released from SSV-transformed cells and can be detected by an autologous goat serum against SSV nonproducer cells (SSV-NP serum) (H.-J. Thiel, R. Hafenrichter, and B. Gregor, 1984, Virology 134, 138-147). This
Ann Intern Med. 1984 Sep;101(3):293-7. Unique Identifier : AIDSLINE MED/84278619
Palmer EL; Ramsey RB; Feorino PF; Harrison AK; Cabradilla C; Francis DP; Poon MC; Evatt BL
Fresh and cultured peripheral blood cells from two patients with hemophilia A and the acquired immunodeficiency syndrome were examined for markers of infection with human T-cell leukemia virus (HTLV) type 1. Neither patient had antibody to membrane antigens of HTLV-infected cells at the time of culture. Electron micro
Ann Intern Med. 1984 Sep;101(3):310-5. Unique Identifier : AIDSLINE MED/84278622
Martin PJ; Shulman HM; Schubach WH; Hansen JA; Fefer A; Miller G; Thomas ED
Two patients with acute leukemia were treated with chemoradiotherapy and allogeneic bone marrow transplantation. Despite the prophylactic use of methotrexate after grafting, both patients developed severe graft-versus-host disease that was refractory to treatment with methylprednisolone. The graft-versus-host disease
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