Chicago : Year Book Medical Publishers, c1983 48 p (Disease-a-month, ISSN 0011-5029 ; v. 30, no. 1 (Oct. 1983)) Unique Identifier : AIDSLINE CAT/8403235
[Bethesda, Md.] : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 1983 17, 9 p (Literature search / National Library of Medicine ; no. 83-25) Unique Identifier : AIDSLINE CAT/8404039
The acquired immune deficiency syndrome (AIDS) has affected more than 2,600 persons since 1981, with the number of reported cases rising exponentially. The disease is characterized by a deficiency in the cell-mediated immune system, which allows entrance to a host of opportunistic infections as well as tumors. The mos
Sex Transm Dis. 1983 Oct-Dec;10(4):202-4. Unique Identifier : AIDSLINE MED/84121784
Jones PG; Cohen RL; Batts DH; Silva J Jr
A homosexual man with the acquired immune deficiency syndrome had an unusually wide array of opportunistic infections. Despite antibiotic treatment over a period of two and a half years, the patient died. Perianal herpetic ulcers, oral candidiasis, cytomegalovirus infection, and di
A case of AIDS manifesting as a necrotic, haemorrhagic anogenital herpes zoster and lymphadenopathy, is described. Investigations of T-lymphocyte subsets showed decreased T4 and slight increase of T8. Electronmicroscopy revealed tubuloreticular virus-like structures in lymphocytes.
To the layers of mystery and controversy surrounding the cause, transmission, and treatment of AIDS is added yet another: children, as well as adults, are contacting AIDS. And, because of their dependent status, children with AIDS are becoming the responsibility of child welfare service providers. The author discusses
Science. 1984 Feb 10;223(4636):602-5. Unique Identifier : AIDSLINE MED/84121276
Daniel MD; King NW; Letvin NL; Hunt RD; Sehgal PK; Desrosiers RC
Macaque monkeys with the recently described acquired immunodeficiency syndrome show a marked defect in T-lymphocyte function and die with opportunistic infections and lymphoproliferative abnormalities. In the study described here a new type D retrovirus was isolated from two Macaca cyclopis with this syndrome. This vi
Science. 1984 Mar 9;223(4640):1083-6. Unique Identifier : AIDSLINE MED/84121324
Marx PA; Maul DH; Osborn KG; Lerche NW; Moody P; Lowenstine LJ; Henrickson RV; Arthur LO; Gilden RV; Gravell M; et al
A type D retrovirus related to but distinct from Mason- Pfizer monkey virus was isolated in vitro from the blood of two rhesus monkeys (Macaca mulatta) with simian acquired immunodeficiency syndrome (SAIDS). Three juvenile rhesus monkeys that were injected intravenously wit
The clinical course of and pathologic findings in a patient with cerebral toxoplasmosis and acquired immune deficiency syndrome were evaluated. The nonspecificity of CNS signs, symptoms, and laboratory features were noted. Appropriate serologic tests and a biopsy of suspicious cerebral lesions were mandatory for confi
A 25-year-old homosexual man with acquired immune deficiency syndrome had CNS toxoplasmosis, mucosal candidiasis, acute otitis media, and sinusitis. These problems persisted despite multiple courses of antibiotic therapy. Surgical drainage proved to be the only effective means of controlling his otorhinologic infectio
Can Med Assoc J. 1984 Feb 15;130(4):370-2. Unique Identifier : AIDSLINE MED/84106178
Landis SJ
During the last 10 years the health care needs of homosexuals have been receiving increasing attention. However, in their attempts to provide health care to this group, physicians must be familiar with the various lifestyles of homosexuals and the types of infection to which they are susceptible. This paper summarizes
Am J Public Health. 1984 Mar;74(3):259-60. Unique Identifier : AIDSLINE MED/84125804
Valdiserri RO; Brandon WR; Lyter DW
Previously defined risk factors in homosexuals with Kaposi s sarcoma may not be causative of AIDS (acquired immune deficiency syndrome) but are an important tool in identifying segments of the homosexual population who are at increased risk for the development of AIDS and who may benefit from health education and surv
The acquired immune deficiency syndrome (AIDS) manifested by opportunistic infections or Kaposi s sarcoma is a newly recognized and often fatal disease. Three patients seen in Syracuse, New York, were noted to have lymphopenia and persistent serum lymphocytotoxic antibodies (LCTAs). In a double blinded study, 25 serum
Fifteen patients with AIDS were hospitalized on the pulmonary service during the period from 1981 to 1983. We were impressed with the frequency and severity of lung involvement in these patients and evaluated them with respect to their pulmonary manifestations of AIDS. The 13 men and two women had a mean age of 32 yea
Ann Clin Res. 1983;15(5-6):203-5. Unique Identifier : AIDSLINE MED/84126623
Valle SL; Ranki A; Repo H; Suni J; Ponka A; Lahdevirta J; Pettersson T
We report here on the first two patients with acquired immune deficiency syndrome (AIDS) in Finland . The first patient, a 37-year-old man, had Kaposi s sarcoma and the other, a 26-year-old man, had pneumonia due to Pneumocystis cari
Community-acquired Pneumocystis carinii pneumonia developed in a young adult patient with dyskeratosis congenita. His hospitalization ended fatally with disseminated candidiasis. Evaluation during the admission showed evidence of cellular immune dysfunction as indicated by skin test anergy and absent lymphocyte prolif
Respiratory tract fluid, produced from an enormous area spanning the mucosa of the nose to the alveolar surface, is a complex mixture of serum transudate and locally secreted proteins and glycomucoproteins and of inflammatory and immune effector cells intermingled. Its analysis is important in understanding the pathog
Sex Transm Dis. 1983 Oct-Dec;10(4):208-15. Unique Identifier : AIDSLINE MED/84121786
Ostrow DG; Altman NL
An epidemic of sexually transmitted diseases, culminating in the emergence of acquired immune-deficiency states, has developed among homosexually active men during the past ten to 15 years. This epidemic is reviewed in relation to causative factors, priorities for control, and recommendations for control and preventio
This report was presented at the June 1983 meeting of the Blood Transfusion National Consultative Commission at the French Ministry of Health. Clinical and epidemiological data on AIDS as well as problems raised by the lack of specific tests for screening of blood donors were briefly summarized. Out of 49 AIDS patient
N Engl J Med. 1984 Feb 23;310(8):492-7. Unique Identifier : AIDSLINE MED/84117397
Clumeck N; Sonnet J; Taelman H; Mascart-Lemone F; De Bruyere M; Vandeperre P; Dasnoy J; Marcelis L; Lamy M; Jonas C; et al
Between May 1979 and April 1983, 18 previously healthy African patients were hospitalized in Belgium with opportunistic infections (cryptococcosis, Pneumocystis carinii pneumonia, central-nervous-system toxoplasmosis, progressive cutaneous herpes simplex virus infection, dissemina
This paper is an editorial review of the relationship between the AIDS, Kaposi sarcoma, adult-T-lymphoma, other neoplasias, HTLV, ATLV and other viruses, amyl-nitrite and immunosuppressive drugs and the possible immunogenetic mechanism related to the immunity suppressor branch due to Ia antigen allogenic reaction simi
Lapin BA; Voevodin AF; Indzhiia LV; Iakovleva LIa; Gallo R
Attempts have been made to induce viral leukemia in monkeys (Papio hamadryas and Macaca arctoides) by inoculating them with blood from humans with different types of leukemias. In hamadryas baboons, the disease spread horizontally. By today 218 P. hamadryas and 5 M. arctoides monkeys had died of malignant lymphoma. Th
The neoplastic T cells from five patients with adult T cell lymphoma/leukemia (ATLL), born in the Caribbean, were studied with respect to immunoregulatory activity on pokeweed mitogen (PWM) driven immunoglobulin (Ig) synthesis as well as surface-marker phenotypes with monoclonal antibodies. The neoplastic T cells in a
C R Seances Acad Sci III. 1983;297(4):195-7. Unique Identifier : AIDSLINE MED/84105997
de The G; McLane MF; Monplaisir N; Lee TH; Essex M
Using indirect membrane immunofluorescence on unfixed HUT 102 cells, 24 out of 184 sera (13%) collected from regular blood donors in Martinique were found positive for HTLV-MA antibodies, 10 being strongly positive (5.4%). Six of th
A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negat
Devare SG; Shatzman A; Robbins KC; Rosenberg M; Aaronson SA
The transforming gene of simian sarcoma virus (SSV), an acute transforming retrovirus, and human platelet-derived growth factor (PDGF), a potent mitogen for connective tissue cells, appear to have arisen from the same or very closely related cellular genes. In an effort to obtain sufficient quantities of the SSV trans
Int J Cancer. 1984 Jan 15;33(1):13-7. Unique Identifier : AIDSLINE MED/84110622
Markham PD; Salahuddin SZ; Macchi B; Robert-Guroff M; Gallo RC
Fresh bone marrow mononuclear leukocytes were used as a target for infection by human T-cell leukemia-lymphoma virus subgroup 1 (HTLV-1) by co-cultivation with virus-positive cell lines. The lines were established from T-cell leukemia-lymphoma patients or HTLV-1-transformed human umbilical cord-blood T cells. Clumps o
Mouse monoclonal antibody to HTLV p19 was used to locate HTLV p19 on the surface of cells and virions by immunofluorescence microscopy (IFM) and immunoelectron microscopy (IEM). When HTLV-producing cells HUT 102 (B2 clone), MT-2 and strain A were used as target cells, HTLV p19 was detected on the surface of cells and
Int J Cancer. 1984 Feb 15;33(2):179-83. Unique Identifier : AIDSLINE MED/84110642
Hayami M; Komuro A; Nozawa K; Shotake T; Ishikawa K; Yamamoto K; Ishida T; Honjo S; Hinuma Y
The prevalence of adult T-cell-leukemia virus (ATLV) infection was examined in Japanese monkeys living naturally in various parts of Japan and in other species of non-human primates imported into and kept in Japan. Sera of 2,650 Japanese monkeys from 41 troops throughout Japan were tested. High incidences of anti-ATLV
We review the biology of transforming retroviruses and their relationship to cellular transforming genes (tumor oncogenes). Evidence is discussed for the involvement of a retrovirus in a newly described syndrome, adult T cell leukemia/lymphoma, which has a high incidence of skin involvement. This virus is related to t
The nucleotide sequence of the 3 long terminal repeat and adjacent viral and host sequences was determined for a bovine leukemia provirus cloned from a bovine tumor. The long terminal repeat was found to comprise 535 nucleotides and to harbor at both ends an imperfect inverted repeat of 7 bases. Promoter-like sequenc
The detection and characterization of oncogenes via RNA tumor viruses (or retroviruses) and the recognition of their location at breakpoints of chromosomal translocations which are frequently found in certain human neoplasms has promoted present understanding of molecular mechanisms underlying carcinogenesis. Oncogene
Cell-free conditioned media from human T cells transformed by human T-cell leukemia-lymphoma virus (HTLV-I) were tested for the production of soluble biologically active factors, including several known lymphokines. The cell lines used were established from patients with T-cell leukemia-lymphoma and from human umbilic
Science. 1984 Mar 9;223(4640):1086-7. Unique Identifier : AIDSLINE MED/84121325
Arya SK; Wong-Staal F; Gallo RC
Activated mature T cells require T-cell growth factor (TCGF) for continuous proliferation. However, many mature T cells infected with human T-cell leukemia-lymphoma virus grow independently of exogenously added TCGF. It is now reported that cells infected with this virus also lack detectable TCGF messenger RNA (less t
Experimental renal-cell carcinoma can be induced by many different chemical carcinogens; dimethyl nitrosoamine has been most studied. The disease so induced in experimental animals closely resembles the spontaneous disease in man in histopathology, course, and other characteristics. Two agents that are probably etiolo
Trans Ophthalmol Soc U K. 1983;103 ( Pt 2):177-90. Unique Identifier : AIDSLINE MED/84122495
Schuman JS; Friedman AH
The ocular manifestations of 34 patients with the Acquired Immune Deficiency Syndrome (AIDS), are reviewed. Cytomegalovirus retinitis was seen in 18 patients, cotton wool spots were observed in 11 patients with Pneumocystis carinii pneumonia; Fungal retinitis and Toxoplasmosis retinochoroiditis were each seen in 2 pat
Virology. 1984 Jan 15;132(1):1-11. Unique Identifier : AIDSLINE MED/84123027
Schneider J; Yamamoto N; Hinuma Y; Hunsmann G
Sera from five Japanese patients with adult T-cell leukemia (ATL) showed in the immunofluorescence test for ATL-associated antigen (ATLA) titers ranging from 320 to 1280. Control sera from three healthy adults were negative. These eight sera were used to immunoprecipitate radiolabeled polypeptides from three cell line
Virology. 1984 Jan 15;132(1):61-70. Unique Identifier : AIDSLINE MED/84123043
Kalyanaraman VS; Jarvis-Morar M; Sarngadharan MG; Gallo RC
Small molecular weight gag gene proteins p19 and p15 of human T-cell leukemia virus (HTLV) were purified to homogeneity from density banded virus, using differential affinities to phosphocellulose at pH 7.9 and 6.5. Using specific radioimmunoassays, p19 and p15 were shown to band with HTLV on sucrose gradients. These
Lapin BA; Iakovleva LA; Voevodin AF; Indzhiia LV; Agrba VZ
An outbreak of malignant lymphoma was registered in a population of hamadryas baboons. Animals inoculated with blood from patients with various forms of leukemia were planted into the stock 10 years ago. 218 out of 3219 animals have already died from lymphoma. The morphological pattern of horizontally-spreading lympho
Grimley PM; Kang YH; Frederick W; Rook AH; Kostianovsky M; Sonnabend JA; Macher AM; Quinnan GV; Friedman RM; Masur H
Blood samples from a series of 12 patients with Kaposi s sarcoma or infectious complications of the acquired immunodeficiency syndrome (AIDS) and from 18 homosexual contacts of AIDS patients were screened for interferon-related tubuloreticular inclusions (TRI) in circulating leukocytes. In the AIDS patients, TRI were
A prospective evaluation of ophthalmologic findings in 26 patients (25 men and one woman) with the acquired immune deficiency syndrome disclosed that 19 patients had significant ocular abnormalities. These included isolated retinal hemorrhages, cotton-wool spots, cytomegalovirus re
Khadem M; Kalish SB; Goldsmith J; Fetkenhour C; O'Grady RB; Phair JP; Chrobak M
Forty-one homosexually active men had ophthalmologic and immunologic evaluations. Four of eight with acquired immune deficiency syndrome (AIDS) had abnormal ocular findings that included cotton-wool spots, retinal hemorrhages, cytomegalovirus , retinitis and conjunctivitis due to cy
Circulating immune complexes from two patients with human T-cell leukaemia/lymphoma virus (HTLV)-related lymphoma were shown to contain the major internal antigen of the virus, p24. The amount of complex-bound p24 in sequential serum samples correlated roughly with tumour cell mass. Small amounts of complex-bound p24
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