The current epidemic of acquired immune deficiency syndrome (AIDS) raises numerous public policy concerns for the medical community. The issues can be divided into two groups. Those concerns which require both immediate action and results are referred to as short-term issues. Those issues whose results will not be for
Seventy six patients with neuroparalytic accidents due to antirabies vaccination (ARV) with BPL vaccine were studied. The mean age of incidence was 26.9 +/- 15.7 years. The suspected source of infection was by the bite of a dog in 72 (97.3%) out of 74. The mean duration of interval between the first dose of ARV and on
N Engl J Med. 1984 Mar 15;310(11):669-73. Unique Identifier : AIDSLINE MED/84142082
Rao TK; Filippone EJ; Nicastri AD; Landesman SH; Frank E; Chen CK; Friedman EA
Of the 92 patients with the acquired immunodeficiency syndrome (AIDS) who were seen at our institution over a two-year period, 9 acquired the nephrotic syndrome (urinary protein greater than 3.5 g per 24 hours) and 2 had azotemia with lesser amounts of urinary protein. Five of these 11 patients had a history of intrav
Rawlinson KF; Zubrow AB; Harris MA; Jackson UC; Chao S
The first case of acquired immune deficiency syndrome (AIDS) in pregnancy is reported. The patient, a drug addict, presented with lymphadenopathy, pulmonary infiltrates, and skin lesions of Kaposi s sarcoma, a tumor rarely found in young women in this country. The helper T-lymphocyte to suppressor T-lymphocyte ratio s
A progressive visual field defect and fever occurred in a 39-year-old homosexual man with acquired immunodeficiency syndrome and Kaposi s sarcoma. Computerized tomography of the brain documented a left parieto-occipital abscess. A specimen obtained at the time of surgical excision of the lesion revealed organisms with
Ann Intern Med. 1984 Apr;100(4):504-11. Unique Identifier : AIDSLINE MED/84152198
Soave R; Danner RL; Honig CL; Ma P; Hart CC; Nash T; Roberts RB
Between April 1982 and June 1983, cryptosporidiosis was diagnosed in six homosexual men. Four patients with the acquired immunodeficiency syndrome had lymphopenia, cutaneous anergy, and profoundly impaired cellular immunity; their cryptosporidiosis was severe, unremitting, and refractory to all therapy. Two patients w
Three intravenous drug abusers (predominantly cocaine) developed a fulminant fungal cerebritis without any other identifiable predisposing factor. Two died and one survived with a severe neurologic deficit. Zygomycetes (nonseptated fungi) were identified in the brain tissue of two victims and Acremonium alabamensis wa
Immunologic evaluation of two unrelated male infants with clinical and laboratory evidence of severe combined immunodeficiency (SCID) revealed T cells with a mature phenotype in the peripheral circulation of both patients although both had biopsy evidence of thymic alymphoplasia. Both had a normal number of T cells wi
Clinical and laboratory evaluations of 181 men were performed; the population studied included 131 homosexual or bisexual men (who were stratified into one of three groups on the basis of symptomatology and abnormal findings on physical examination), 39 heterosexual men (who served as controls), and 11 men with acquir
A case of Kaposi s sarcoma, which first appeared as an erythematous oral lesion, in a patient with AIDS is presented. Current concepts regarding these disease entities are reviewed, and recommendations for protection of personnel when providing care for AIDS patients are outlined.
To investigate B-cell function in acquired immune deficiency syndrome (AIDS), we immunized a group of patients with AIDS with pneumococcal polysaccharide (tetradecavalent) and protein (keyhole-limpet hemocyanin) antigens. Antibody responses were determined three to four weeks after immunization. Compared with controls
Cowan MJ; Hellmann D; Chudwin D; Wara DW; Chang RS; Ammann AJ
Acquired immune deficiency syndrome (AIDS) has been reported in previously healthy homosexual or bisexual males, intravenous drug users, heterosexual men with hemophilia, and Haitians. The finding of heterosexual hemophiliacs with AIDS has raised the possibility of a transmittable blood-borne agent as a cause of this
Stern RG; Gamsu G; Golden JA; Hirji M; Webb WR; Abrams DI
The presence of mediastinal and/or hilar adenopathy was assessed from the chest radiographs of two groups of homosexual men: 30 with diffuse, persistent lymphadenopathy syndrome and 45 with acquired immunodeficiency syndrome (AIDS). Intrathoracic adenopathy was not seen on the chest radiographs of the 30 men having di
Previously the authors demonstrated that most patients with AIDS have serum antilymphocyte antibodies. Therefore, in an attempt to decrease these antibodies and at least transiently increase blood lymphocytes, they treated one AIDS patient with three courses of plasmapheresis. During or after each course, his T4 lymph
Am J Med. 1984 Mar;76(3):479-86. Unique Identifier : AIDSLINE MED/84150922
Wong B
In patients with compromised host defenses, diseases caused by protozoans and nematodes appeared, a few years ago, to be declining in importance. However, the outbreak of the acquired immunodeficiency syndrome (AIDS) among homosexual men, parenteral drug abusers, and other groups has made it necessary for physicians t
Am J Med. 1984 Mar;76(3):487-92. Unique Identifier : AIDSLINE MED/84150923
Auerbach DM; Darrow WW; Jaffe HW; Curran JW
The possibility that homosexual men with the acquired immune deficiency syndrome (AIDS) had been sexual partners of each other was studied. Of the first 19 homosexual male AIDS patients reported from southern California, names of sexual partners were obtained for 13. Nine of the 13 patients had sexual contact with one
Coleman DL; Dodek PM; Golden JA; Luce JM; Golden E; Gold WM; Murray JF
The records of 9 adult male patients with the acquired immune deficiency syndrome (AIDS) and biopsy-proved Pneumocystis carinii pneumonia were reviewed to determine the correlation between serial pulmonary function tests and the presence or absence of Pneumocystis organisms in subsequent bronchoscopy specimens. At dia
South Med J. 1984 Feb;77(2):246-8. Unique Identifier : AIDSLINE MED/84147015
Graham BS; Hinson MV; Bennett SR; Gregory DW; Schaffner W
A patient with the acquired immunodeficiency syndrome was found to have a continuous bacillemia of Mycobacterium avium-intracellulare by examination of Kinyoun-stained buffy coat smears. There were 29 cells/cu mm that contained acid-fast bacilli (AFB) and 1.5 X 10(5) AFB/ml of whole blood. The cells of the reticuloend
Am J Med. 1984 Mar;76(3):501-8. Unique Identifier : AIDSLINE MED/84150925
Haverkos HW
Pneumocystis carinii pneumonia has been recognized in about 60 percent of patients with the acquired immune deficiency syndrome (AIDS). The Centers for Disease Control, in collaboration with 19 medical centers, retrospectively studied 282 biopsy-confirmed cases of P. carinii pneumonia to determine the efficacy and saf
To examine the cellular immune defect that predisposes patients with the acquired immunodeficiency syndrome (AIDS) to opportunistic infections, we tested T lymphocytes from 16 patients for the capacity to secrete macrophage-activating products (lymphokines) including gamma interferon. Mononuclear cells from 10 of 11 p
Ann Intern Med. 1984 Apr;100(4):495-9. Unique Identifier : AIDSLINE MED/84152196
Gordin FM; Simon GL; Wofsy CB; Mills J
We reviewed the charts of 38 patients with the acquired immunodeficiency syndrome who were treated for Pneumocystis carinii pneumonia. Only 5 of 37 patients started on trimethoprim-sulfamethoxazole were able to complete treatment; in 29 patients drug toxicity occurred and in 19 treatment was changed due to adverse rea
Ann Intern Med. 1984 Apr;100(4):499-504. Unique Identifier : AIDSLINE MED/84152197
Evatt BL; Ramsey RB; Lawrence DN; Zyla LD; Curran JW
Since mid-1981 the Centers for Disease Control (CDC) has received reports of more than 1900 cases of the acquired immunodeficiency syndrome. These cases had either Kaposi s sarcoma confirmed by biopsy or a life-threatening opportunistic infection confirmed by biopsy or culture. In January 1982 a hemophiliac with Pneum
Cancer Lett. 1984 Feb;22(1):11-21. Unique Identifier : AIDSLINE MED/84129969
Okada M; Koyanagi Y; Kobayashi N; Tanaka Y; Nakai M; Sano K; Takeuchi K; Hinuma Y; Hatanaka M; Yamamoto N
Experimental transmission of adult T-cell leukemia (ATL) virus (ATLV) into human B lymphocytes was attempted. Cocultivation of B-cell rich fraction of peripheral blood from a healthy adult with X-ray irradiated ATLV producer MT-2 cells resulted in the establishment of OKA(B) cell line co-infected with both Epstein-Bar
Epstein-Barr (EB) virus serology was correlated with the results of immunological investigations of three inherited immunodeficiency diseases, in an attempt to understand the immune mechanisms controlling EB virus infection. In nine patients with Wiskott-Aldrich syndrome (WAS), the constant lack of anti-EB virus assoc
Hattori S; Imagawa K; Shimizu F; Hashimura E; Seiki M; Yoshida M
Envelope gene product of human T-cell leukemia virus was identified as a glycoprotein with an apparent molecular weight of 62,000 daltons, by using rabbit antiserum against a synthetic decapeptide whose structure had been predicted from the nucleotide sequence. Sera from patients with adult T-cell leukemia also reacte
Int J Cancer. 1984 Mar 15;33(3):287-91. Unique Identifier : AIDSLINE MED/84134575
Miyakoshi H; Koide H; Aoki T
Human T-cell leukemia/lymphoma virus (HTLV)-producing cells were lysed by peripheral mononuclear cells (PMNC) from both anti-HTLV antibody-positive and -negative healthy persons in the presence of natural humoral antibodies against HTLV-related antigens (antibody-dependent cellular cytotoxicity, ADCC). PMNC from patie
Int J Cancer. 1984 Mar 15;33(3):293-8. Unique Identifier : AIDSLINE MED/84134576
Suni J; Narvanen A; Wahlstrom T; Lehtovirta P; Vaheri A
In previous studies we detected retrovirus RD114 p30-related antigen in human placental syncytiotrophoblasts and antibodies in cord blood sera. We now report that a monoclonal IgG antibody specific for the p19 protein of human T-cell leukemia virus (HTLV) reacts with human syncytiotrophoblastic antigen. When used in t
Recent work implicating microbial factors in the pathogenesis of several oral soft tissue diseases is discussed. These conditions include recurrent aphthous ulceration, oral cancer, Sjogren s syndrome, and the oral lesions of AIDS (the acquired immune deficiency syndrome). This paper reviews some recent work on these
Hardy AM; Wajszczuk CP; Suffredini AF; Hakala TR; Ho M
Fourteen of 156 renal-transplant recipients treated with cyclosporine and steroids developed Pneumocystis carinii-related pneumonia (PCP) over a 19-month period. This was a significant change from past experience with this disease in renal-transplant patients receiving azathioprine and steroids (six cases among 179 pa
T cells from the peripheral blood of a T-cell chronic lymphocytic leukemia (T-CLL) patient, cultured in the presence of interleukin-2 ( IL-2 ), were found to express the p19 structural core protein of the human T-cell leukemia/lymphoma virus (HTLV) and to release type C
T cells from the peripheral blood of a T-cell chronic lymphocytic leukemia (T-CLL) patients, were expanded by culture in the presence of interleukin-2 ( IL-2 ). In contrast to the original leukemic T cells that showed a complete lack of suppressor activity, the prolifera
The work reported here demonstrates the possibility of rapid generation of highly transforming viruses from rabbit epithelial corneal cells (SIRC) originated from simian sarcoma associated virus (SSAV). The results of the experiments indicate a possible association of the phenomenon of phenotypic transformation with t
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1079-83. Unique Identifier : AIDSLINE GENBANK/M10060
Shimotohno K; Golde DW; Miwa M; Sugimura T; Chen IS
The nucleotide sequence of the human T-cell leukemia virus type II (HTLV-II) long terminal repeat (LTR) and its surrounding regions were determined. Our results show the following structural features: (i) the LTR is 763 base pairs (bp) in length and consists of 314 +/- 1 bp of region U3, 248 +/- 1 bp of region R, and
Human T-cell leukemia virus IIMo (HTLV-IIMo) is a human retrovirus isolated from a patient with a T-cell hairy cell leukemia. This virus has been shown to have core protein (gag) antigens similar to, but distinct from, those of all known isolates of the prototype human T-cell leukemia virus (HTLV-I). We have used a su
Science. 1984 Mar 16;223(4641):1195-7. Unique Identifier : AIDSLINE MED/84146749
Guo HG; Wong-Stall F; Gallo RC
Antibodies reactive with proteins of human T-cell leukemia virus (HTLV) can be found in Old World monkeys. A T-lymphocyte cell line established from a seropositive baboon (Papio cynocephalus) was analyzed for the presence of viral DNA sequences. The provirus found in these cells was related to but distinct from HTLV s
Science. 1984 Mar 23;223(4642):1293-6. Unique Identifier : AIDSLINE MED/84146757
Mitsuya H; Guo HG; Megson M; Trainor C; Reitz MS Jr; Broder S
Human T-cell leukemia-lymphoma virus (HTLV) is a human C-type retrovirus that can transform T lymphocytes in vitro and is associated with certain T-cell neoplasms. Recent data suggest that, in the United States , patients with acquired immunodeficiency syndrome (AIDS), homosexual men wi
Science. 1984 Mar 23;223(4642):1309-12. Unique Identifier : AIDSLINE MED/84146762
Jaffe HW; Francis DP; McLane MF; Cabradilla C; Curran JW; Kilbourne BW; Lawrence DN; Haverkos HW; Spira TJ; Dodd RY; et al
An assay for antibodies to membrane antigens of cells infected by human T-cell leukemia virus was used to examine serum from persons who donated blood to 12 patients with acquired immunodeficiency syndrome (AIDS) associated with blood transfusions. The occurrence of positive results in the assay was significantly grea
South Med J. 1984 Feb;77(2):227-8. Unique Identifier : AIDSLINE MED/84147008
Ratner J; Thomas A
In summary, we have described a homosexual patient who died of Kaposi s sarcoma and overwhelming disseminated opportunistic infections. Review of the literature attests to the severe alterations of immune surveillance inherent in the homosexual population as a whole and the need for vigorous clinical investigation whe
Two independent isolates of human leukemia virus, human T-cell leukemia virus (HTLV) and adult T-cell leukemia virus (ATLV), are shown to be the same by blotting analysis using gene-specific probes and restriction enzymes. Therefore, Japanese ATL virus and Caribbean HTLV type I, which are exogenous for human, have a c
McIntosh K; Kurachek SC; Cairns LM; Burns JC; Goodspeed B
An infant with severe combined immunodeficiency syndrome (SCIDS) secondary to adenosine deaminase deficiency had pneumonitis and combined infection with respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3). Four separate courses of ribavirin were delivered by small-particle aerosol. The PIV3 disappe
Am J Gastroenterol. 1984 Mar;79(3):201-5. Unique Identifier : AIDSLINE MED/84150793
Frank D; Raicht RF
Gastrointestinal complications are an important aspect of the acquired immune deficiency syndrome. In this report we describe two male homosexuals with the acquired immune deficiency syndrome whose gastrointestinal symptoms culminated in the complication of intestinal perforation. Cytomegalovirus inclusions are seen p
Am J Med. 1984 Mar;76(3):493-500. Unique Identifier : AIDSLINE MED/84150924
Selik RM; Haverkos HW; Curran JW
This report summarizes results of surveillance for the acquired immune deficiency syndrome (AIDS) in the United States by the Centers for Disease Control through the first quarter of 1983. Surveillance has been predominantly passive, supplemented by active follow-up of requests to the
Ann Intern Med. 1984 Apr;100(4):543-57. Unique Identifier : AIDSLINE MED/84152210
Broder S; Bunn PA Jr; Jaffe ES; Blattner W; Gallo RC; Wong-Staal F; Waldmann TA; DeVita VT Jr
Human T-cell leukemia/lymphoma virus is a unique family of T-cell tropic, human, type-C retroviruses. The discovery of this class of retroviruses provides the first proven link between retroviruses and cancer in humans. This virus is endemic in certain parts of the world, including the southeastern
Four patients, including three with the acquired immunodeficiency syndrome (AIDS), were treated with high-dose, buffy coat-derived alpha-interferon for progressive cytomegalovirus retinitis. Two of these patients had decreased viruria during therapy and the other two had increased
Ann Surg. 1984 Mar;199(3):332-9. Unique Identifier : AIDSLINE MED/84152978
Potter DA; Danforth DN Jr; Macher AM; Longo DL; Stewart L; Masur H
Acquired immune deficiency syndrome (AIDS) is a recently recognized entity characterized by a deficiency in cell mediated immune response. The syndrome is manifested by the development of otherwise rare malignant neoplasms and severe life-threatening opportunistic infections. Case histories of five AIDS patients evalu
Functional deficits in lymphocyte interaction following occasional or chronic exposure to inhaled nitrites may be a potential contributing but not the etiologic factor in the acquired immunodeficiency syndrome (AIDS). We evaluated the effect of amyl nitrite vapors on mononuclear cell function and demonstrated function
Lancet. 1984 Mar 3;1(8375):478-80. Unique Identifier : AIDSLINE MED/84140646
Downing RG; Eglin RP; Bayley AC
16 Zambian patients with Kaposi s sarcoma (KS) were studied to determine whether they had evidence of lymphopenia with decreased T helper/T suppressor (Th/Ts) ratios or previous infection with opportunistic pathogens. Serological tests for viruses commonly associated with the acquired immunodeficiency syndrome (AIDS)
Lancet. 1984 Mar 24;1(8378):649-52. Unique Identifier : AIDSLINE MED/84140791
Mitsuya H; Matis LA; Megson M; Cohen OJ; Mann DL; Gallo RC; Broder S
Six patients with malignant disorders associated with human T-cell leukaemia/lymphoma virus (HTLV) were studied to see whether long-term cultures of immune T cells reactive against HTLV-infected tumour cells could be achieved. Immune T-cell lines could not be developed from the cells of five patients who died or event
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