Int J Psychiatry Med. 1983-84;13(4):255-60. Unique Identifier : AIDSLINE MED/84160901
Loewenstein RJ; Sharfstein SS
Acquired Immune Deficiency Syndrome is a newly described, highly virulent, idiopathic syndrome characterized by lymphocyte dysfunction, multiple opportunistic infections and lymphoma, which primarily affects previously healthy, promiscuous homosexual males. Dementia and delirium due to infection and/or disseminated ly
Several outbreaks of fatal opportunistic infections and tumors have recently been reported among homosexual men in the United States . Almost all patients had evidence of cellular immunodeficiency. We have studied a French homosexual man with fatal central nervous system toxoplasmosis.
Cytogenetic studies were done in two cases of Burkitt s lymphoma in homosexual individuals with possible acquired immune deficiency syndrome (AIDS). The chromosomal abnormalities found are consistent with those previously described in the nonendemic form of Burkitt s lymphoma, with one of the two patients having the v
A 31-year-old homosexual man with acquired immunodeficiency syndrome (AIDS) had cutaneous herpetiform lesions that showed numerous encapsulated organisms on Tzanck preparation. Subsequent cultures of cerebrospinal fluid and skin biopsy specimens substantiated a diagnosis of disseminated cryptococcosis. Cutaneous crypt
Stromberg K; Benveniste RE; Arthur LO; Rabin H; Giddens WE Jr; Ochs HD; Morton WR; Tsai CC
A novel type D retrovirus was isolated by cocultivation of explants of fibromatous tissue from a rhesus monkey (Macaca mulatta) with immunodeficiency and retroperitoneal fibromatosis. This type D virus, isolated from a macaque with simian acquired immunodeficiency syndrome (SAIDS-D/Washington), is exogenous and is par
Science. 1984 May 11;224(4649):603-5. Unique Identifier : AIDSLINE MED/84172229
Current WL; Haynes TB
Protozoan parasites of the genus Cryptosporidium cause a short-term, flu-like, gastrointestinal illness in immunocompetent persons and severe, persistent, life-threatening diarrhea in immunodeficient individuals. No effective therapy is available for the treatment of cryptosporidiosis in the immunodeficient host. Comp
South Med J. 1984 Apr;77(4):533-4. Unique Identifier : AIDSLINE MED/84172394
Schroeder HW Jr; Yarrish RL; Perkins TF; Lee C
A 27-year-old previously healthy male Haitian had sequential disseminated tuberculosis and toxoplasmosis during a three-month period. The former appeared to respond to antituberculous therapy; the latter proved fatal and was diagnosed only at autopsy. We suspect acquired immune deficiency syndrome (AIDS) as the underl
Am J Med Sci. 1984 Mar-Apr;287(2):47-8. Unique Identifier : AIDSLINE MED/84176080
Wittner M; Goldfarb J; Vogl S; Tanowitz HB
Fatal cryptosporidiosis in a bisexual immunosuppressed man with disseminated Kaposi s sarcoma and intractable diarrhea is described. Cryptosporidium sp. was isolated from the stool antemortem by Sheather s floation technique. This parasite should be considered in immunosuppressed hosts with chronic diarrhea when routi
Ann Intern Med. 1984 May;100(5):671-6. Unique Identifier : AIDSLINE MED/84176875
Groopman JE; Gottlieb MS; Goodman J; Mitsuyasu RT; Conant MA; Prince H; Fahey JL; Derezin M; Weinstein WM; Casavante C; et al
In a randomized prospective study we tested the toxicity and efficacy of recombinant alpha-2 interferon in the treatment of Kaposi s sarcoma associated with the acquired immunodeficiency syndrome. High doses (50 X 10(6) U/m2 body surface area, intravenously) or low doses (1 X 10(6) U/m2, subcutaneously) of recombinant
A 24-year-old heterosexual man had severe proctalgia associated with nonspecific proctitis. Within a few days, perineal and lower extremity paresthesias, intermittent urinary retention, inguinal lymphadenopathy, lower extremity arthralgias, and aseptic meningitis developed. Serologic studies demonstrated a fourfold ri
The X-linked lymphoproliferative syndrome may be the model of a EBV-induced immunodeficiency which may lead, in case of T-insufficiency, either to myeloid aplasia, or to a polyclonal proliferation of the malignant, infectious mononucleosis (MI) type or, if it becomes secondarily monoclonal, non-hodgkin lymphoma (LNH).
G Ital Med Lav. 1983 Mar;5(2):89-93. Unique Identifier : AIDSLINE MED/84159344
Maini M; Zelaschi F
The electrodiagnostic sensitive exam on patients suffering from a chronic pain treated which transcutaneous electroanalgesia stimulation. G. Ital Med Lav 1983; 5: 89 - 94. The AA carry out this exam before, during and after the sittings of electroanalgesia. The only parameter to vary in such research is the sensitive
Ann Pathol. 1984 Jan-Mar;4(1):3-17. Unique Identifier : AIDSLINE MED/84154116
Diebold J
In this second part, the dysimmunitary conditions which associate a polyclonal hypergammapathy and adenopathy are studied. The latter simulate a malignant lymphoma both clinically and histologically, hence the term sometimes used: pseudo-lymphoma. Above all, these dysimmunitary states should be considered as real pret
The acquired immune deficiency syndrome (AIDS) has been reported in more than 2800 persons in the United States (70 per cent of whom are homosexually active men). AIDS is manifested by impaired cell-mediated immunity that results in various opportunistic infections (especially pneumoni
Moskowitz LB; Hensley GT; Chan JC; Conley FK; Post MJ; Gonzalez-Arias SM
Seven brain biopsies from patients with the acquired immune deficiency syndrome (AIDS) were reviewed. Toxoplasmic encephalitis was diagnosed in five patients, neurotuberculosis in one patient, and no diagnosis was made in the seventh patient. Frozen sections and smears enabled a rapid diagnosis to be made in four pati
Recent changes in thinking about the host-parasite relationship are reviewed. New agents have been identified as respiratory and urinary tract pathogens. Agents previously considered benign, eg., Staphylococcus epidermidis, have become increasingly important causes of disease. Finally, studies on patients with the acq
Public Health Rep. 1984 Mar-Apr;99(2):200-5. Unique Identifier : AIDSLINE MED/84170865
Perry SW; Tross S
A retrospective review of the charts of 52 patients with acquired immune deficiency syndrome (AIDS) in the New York Hospital was conducted to determine the prevalence of recorded psychiatric complications and the use of psychiatric consultation. Neuropsychiatric complications were found to be pervasive clinical featur
Public Health Rep. 1984 Mar-Apr;99(2):206-12. Unique Identifier : AIDSLINE MED/84170866
Ginzburg HM
Acquired immune deficiency syndrome (AIDS), a new epidemic disease characterized by dysfunction of cellular immunity, is most common among homosexual and bisexual males with multiple sexual partners and users of intravenous drugs. AIDS appears to be spread by contact with blood products and body fluids. Not only is th
Immunoperoxidase evaluation of cryostat sections from acquired immune deficiency syndrome (AIDS) or prodromal nodes indicated that the majority (75%) had T8 dominance as contrasted to reactive hyperplasia nodes of unknown origin which had 80% T4 dominance. The cells in the AIDS nodes in the interfollicular and medulla
Ann Intern Med. 1984 May;100(5):663-71. Unique Identifier : AIDSLINE MED/84176874
Kovacs JA; Hiemenz JW; Macher AM; Stover D; Murray HW; Shelhamer J; Lane HC; Urmacher C; Honig C; Longo DL; et al
Clinical features of 49 episodes of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome were compared with those of 39 episodes in patients with other immunosuppressive diseases. At presentation patients with the syndrome were found to have a longer median duration of symptoms (28 da
Ann Intern Med. 1984 May;100(5):693-6. Unique Identifier : AIDSLINE MED/84176880
Ho JL; Poldre PA; McEniry D; Howley PM; Snydman DR; Rudders RA; Worthington M
A 34-year-old man who used intravenous drugs developed the acquired immunodeficiency syndrome with lymphadenopathy, Mycobacterium tuberculosis pneumonia, and progressive multifocal leukoencephalopathy. Early biopsy specimens of the lymph node showed hyperplasia without evidence of lymphoma. Later, immunologic analysis
A patient with acquired immunodeficiency syndrome is described. Both retinae were severely affected. Vision was reduced to light perception with projection incerta in the right eye and finger counting at 1.5 m in the left eye. Eye involvement is common in this syndrome, appearing at an early stage of the disease. The
On exogenous stimulus immunocompetent leucocytes produce antigen-specific factors, which essentially determine the magnitude and duration of T-lymphocyte dependent immunoreactions. Interleukin 1 (IL-1, monokin) and interleukin 2 ( IL-2 , lymphokine) form a bimodal amplif
The human germ-line positions of the oncogenes ABL, SIS, and FES, the cellular counterparts of the v-onc genes of Abelson murine leukemia virus, simian sarcoma virus, and feline sarcoma virus, respectively, have been determined by in situ molecular hybridization of 3H-labeled v-onc gene probes to meiotic pachytene chr
An outbreak of unexplained immune deficiency associated with opportunistic infection and Kaposi s sarcoma is occurring in the USA and other parts of the world. Affected individuals with what had come to be known as the acquired immune deficiency syndrome (AIDS) have a high mortality. Epidemiological features suggest t
We present the pathological findings in a case of acquired immunodeficiency syndrome (AIDS) in a patient with no known risk factor. Postmortem examination showed klebsiella lung abscess, generalised cytomegalovirus infection, cerebral toxoplasmosis, and a primary cerebral lymphoma.
Tateno M; Kondo N; Itoh T; Chubachi T; Togashi T; Yoshiki T
Cocultivation of spleen cells, lymph node cells, and thymocytes of female Wistar-King-Aptekman rats with short-term cultured male adult T cell leukemia (ATL) cells in the presence of 5-bromo-2 -deoxyuridine (BrdUrd) resulted in the establishment of rat lymphoid cell lines, TARS-1, TARL-2, and TART-1. Cytogenetic analy
Palker TJ; Scearce RM; Miller SE; Popovic M; Bolognesi DP; Gallo RC; Haynes BF
Four monoclonal antibodies, human T cell leukemia-lymphoma virus (HTLV) 6, 7, 8, and 9, which react with the 24,000 dalton internal core protein of HTLVI, have been developed. These monoclonal antibodies reacted with only HTLV-infected cells and not with a broad spectrum of normal, neoplastic, mitogen-stimulated, or v
Nature. 1984 Mar 29-Apr 4;308(5958):464-7. Unique Identifier : AIDSLINE MED/84168146
Clarke MF; Westin E; Schmidt D; Josephs SF; Ratner L; Wong-Staal F; Gallo RC; Reitz MS Jr
The mechanism of leukaemogenic transformation by human T-cell leukaemia/lymphoma virus (HTLV), a retrovirus implicated in the aetiology of certain adult T-cell leukaemias and lymphomas, is unknown but is conceivably associated with the expression of the cellular analogues of retroviral oncogenes. The HUT-102 cell line
Rodrigues MM; Palestine A; Nussenblatt R; Masur H; Macher AM
A 42-year-old bisexual man with the acquired immunodeficiency syndrome, cryptococcal meningitis, disseminated Mycobacterium avium-intracellulare with mycobacteremia, and oropharyngeal candidiasis developed unilateral retinitis and bilateral cotton wool patches. Histopathologic examination revealed unilateral necrotizi
Screening of 70 asymptomatic homosexual men in Copenhagen revealed that 13 (19%) had T-helper to T-suppressor (H/S) ratios less than or equal to 1.0. Clinical and immunological follow-up examinations for 2-7 months (mean, 5.2 months) disclosed that none of the 13 men developed the acquired immunodeficiency syndrome (A
Science. 1984 May 4;224(4648):497-500. Unique Identifier : AIDSLINE MED/84172211
Popovic M; Sarngadharan MG; Read E; Gallo RC
A cell system was developed for the reproducible detection of human T-lymphotropic retroviruses (HTLV family) from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS). The cells are specific clones from a permissive human neoplastic T-cell line.
Science. 1984 May 4;224(4648):500-3. Unique Identifier : AIDSLINE MED/84172212
Gallo RC; Salahuddin SZ; Popovic M; Shearer GM; Kaplan M; Haynes BF; Palker TJ; Redfield R; Oleske J; Safai B; et al
Peripheral blood lymphocytes from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS) were grown in vitro with added T-cell growth factor and assayed for the expression and release of human T-lymphotropic retroviruses (HTLV). Retroviruses belong
The two main subgroups of the family of human T-lymphotropic retroviruses (HTLV) that have previously been characterized are known as HTLV-I and HTLV-II. Both are associated with certain human leukemias and lymphomas. Cell surface antigens (p61 and p65) encoded by HTLV-I are frequently recognized, at low titers, by an
Science. 1984 May 4;224(4648):506-8. Unique Identifier : AIDSLINE MED/84172214
Sarngadharan MG; Popovic M; Bruch L; Schupbach J; Gallo RC
In cats, infection with T-lymphotropic retroviruses can cause T-cell proliferation and leukemia or T-cell depletion and immunosuppression. In humans, some highly T4 tropic retroviruses called HTLV-I can cause T-cell proliferation and leukemia. The subgroup HTLV-II also induces T-cell proliferation in vitro, but its ro
Science. 1984 May 11;224(4649):607-10. Unique Identifier : AIDSLINE MED/84172231
Schupbach J; Sarngadharan MG; Gallo RC
Cross-reactive antigens of molecular size of 61,000 to 68,000 daltons are found on the surface of human cells infected by human T-cell leukemia-lymphoma virus (HTLV). They are recognized by antibodies from patients with adult T-cell leukemias and lymphomas, from healthy carriers of HTLV, and from patients with the acq
Issues related to the development of cancer of the urogenital system in men and women and the possible role played by agents of sexually transmitted diseases are discussed. Research evidence supporting the role of specific viral agents in the etiology of cancer of the uterine cervix, penis, testis, prostate, and urina
An autologous antiserum against simian sarcoma virus-infected nonproducer cells (SSV-NP cells) recognized a SSV transformation-specific glycopeptide (SSV-TrSgp) [H.-J. Thiel, T.J. Matthews, E.M. Broughton, A.M. Butchko, and D.P. Bolognesi (1981) Virology 112, 642-650]. Gel filtration of this component on a Sephacryl S
Am J Med. 1984 Apr;76(4):734-6. Unique Identifier : AIDSLINE MED/84176062
Roberts CJ
Progressive pulmonary coccidioidomycosis has not been previously reported in the setting of acquired immune deficiency syndrome (AIDS). A patient with AIDS, progressive pulmonary coccidioidomycosis, Pneumocystis carinii pneumonia, and disseminated
Jaffe ES; Blattner WA; Blayney DW; Bunn PA Jr; Cossman J; Robert-Guroff M; Gallo RC
The human T-cell leukemia/lymphoma virus (HTLV) is a novel Type-C retrovirus isolated from patients with post-thymic T-cell malignancies. Thirteen patients diagnosed in the United States were identified as having antibodies to HTLV and a typical clinicopathologic syndrome characteristi
Tocci MJ; Livelli TJ; Perry HC; Crumpacker CS; Field AK
The nucleoside analog 2 -nor-2 -deoxyguanosine (2 NDG) effectively inhibits the replication of several laboratory and clinical isolates of human cytomegalovirus . These isolates included viruses obtained from congenitally infected infants and patients suffering from acquired immune
Lancet. 1984 Mar 31;1(8379):698-702. Unique Identifier : AIDSLINE MED/84166794
Lifson JD; Benike CJ; Mark DF; Koths K; Engleman EG
The lymphokine interleukin-2 is required for the development of various cell-mediated immune functions that are known to be deficient in patients with acquired immunodeficiency syndrome (AIDS). The effects of pure human recombinant interleukin-2 (rIL-2), produced by Escherichia coli containing the cloned human gene, o
A human T-lymphotropic retrovirus was isolated from cultured T lymphocytes from two siblings with haemophilia B. Patient 2 was healthy, but patient 1 had acquired immunodeficiency syndrome. The retrovirus differed from human T-cell leukaemia virus (HTLV) but it was similar to the lymphadenopathy-associated retrovirus
Anderson MG; Dixey J; Key P; Ellis DS; Tovey G; McCaul TF; Murray-Lyon IM; Gazzard B; Lawrence A; Evans B; et al
Ultrastructural changes (tubuloreticular structures and tube and ring shaped forms) previously described in patients with acquired immunodeficiency syndrome (AIDS) are described for the first time in the lymph nodes and circulating lymphocytes of patients with persistent lymphadenopathy. These observations support the
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