Acquired immune deficiency syndrome, or AIDS, is an unexplained severe disturbance of the cell-mediated immune system that renders victims susceptible to a group of otherwise-rare diseases and infections, chiefly Kaposi s sarcoma and Pneumocystis carinii pneumonia. AIDS has been the object of intensive research since
We report a patient with acquired immunodeficiency syndrome whose clinical presentation and histologic features resembled Whipple s disease. The unique feature of this case was the absence of Whipple s bacillus and the presence of Mycobacterium avium-intracellulare within macrophages infiltrating the small intestinal
Acid-fast stained necroscopic sections from a fatal case of acquired immunodeficiency syndrome (AIDS) and Kaposi s sarcoma (KS) occurring in a 48-year-old homosexual man, were studied for the presence of bacteria. Variably acid-fast coccoid forms suggestive of cell wall deficient bacteria, were observed within section
N Engl J Med. 1983 Oct 20;309(16):945-50. Unique Identifier : AIDSLINE MED/84013950
Pape JW; Liautaud B; Thomas F; Mathurin JR; St Amand MM; Boncy M; Pean V; Pamphile M; Laroche AC; Johnson WD Jr
To identify the characteristics of the acquired immunodeficiency syndrome (AIDS) as it occurs in Haiti , we studied 61 previously healthy Haitians who had diagnoses of either Kaposi s sarcoma (15), opportunistic infections (45), or both (1) established in Haiti between June 1979 and
Whelan MA; Kricheff II; Handler M; Ho V; Crystal K; Gopinathan G; Laubenstein L
CT examination of the central nervous system was performed in 19 patients with acquired immunodeficiency syndrome (AIDS). Eighteen patients were homosexuals, and five drug abusers. Parenchymal and meningeal inflammations were seen in patients with intracranial manifestations of the disease. The most common demonstrabl
Central nervous system complications depicted by CT in ten patients with acquired immunodeficiency syndrome are described. Three patients had multifocal intra-axial enhancing lesions representing atypical brain abscesses (two with toxoplasmosis, one with candidiasis). A fourth patient with multifocal ring lesions whos
Patients suffering from acquired immunodeficiency syndrome (AIDS) are being encountered more and more frequently. Because of their immunosuppressed state, they often present with opportunistic infections of the cerebrum. Herein, the case of a patient with AIDS who had cerebral toxoplasmosis is reported. Although the c
We studied two cases of cryptosporidiosis in patients with acquired immune deficiency syndrome. In one patient, the gallbladder was affected in addition to gastric and intestinal involvements. This is the first human case in which Cryptosporidium has been found in the biliary tract. It is important that pathologists b
Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a well-described clinicopathologic entity that tends to occur in older persons. A recently described syndrome, the acquired immunodeficiency syndrome (AIDS), occurring predominantly in young homosexual men, shows considerable clinical overlap with AILD.
In 1975-1982, autopsies of 201 patients dying with leukemias and other tumors of hemopoietic system revealed infectious complications in 68.6%, among them pneumonias in 46.8%, sepsis in 10.9%, and inflammatory-necrotic processes of the digestive tract in 19.4%. More frequent occurrence of infectious complications in a
Clinical disease states encountered in the acquired immunodeficiency syndrome (AIDS) have been reviewed with an emphasis on oral Kaposi s sarcoma. The disease is reaching epidemic proportions among homosexual males and is characterized by onset of fever, malaise, diarrhea, and lymphadenopathy. Subsequent to these init
The radiographic findings in 39 patients with acquired immunodeficiency syndrome (AIDS) were reviewed. Twenty five of the 39 patients had infections and 14 had Kaposi sarcoma and opportunistic infections. A prodromal phase, which is seen in many patients and is associated with lymphoid hyperplasia, lymphadenopathy, an
Two patients with common varied immunodeficiency both had increased immunoglobulin responses for a limited period of time on acquiring a bacterial infection. In one patient a relatively short-lived high-antibody response was produced on vaccination with tetanus toxoid. Although the patients varied in their course of i
A patient with Kaposi s sarcoma and the acquired immune deficiency syndrome became acutely febrile and dyspneic. Although chest roentgenograms and findings from arterial blood oxygenation studies were normal, bronchoscopy disclosed heavy Pneumocystis carinii infection. The patient was treated with trimethoprim-sulfame
An overview of the interferons is presented. A description of something of what is known about them is given, including: their genes; their protein structures and characteristics; their mechanisms of actions; and their varied biological effects emphasising particularly their immunomodulatory actions. Finally, a brief
In the present epidemic of opportunistic infections affecting homosexual men, systemic, persistent, unexplained lymphadenopathies have frequently accompanied and often preceded other manifestations of the acquired immunodeficiency syndrome (AIDS). Studies of the lymphadenopathies associated with AIDS have not yet been
The occurrence of the acquired immune deficiency syndrome (AIDS) in patients with hemophilia has suggested that an infectious agent transmitted through the frequent use of pooled blood products could be responsible. To determine if the amount or type of factor VIII preparation alters the risk of acquiring immune defec
Mann DL; Popovic M; Murray C; Neuland C; Strong DM; Sarin P; Gallo RC; Blattner WA
Human T cell lymphocyte lines, established from lymphoid tissues from patients with adult T cell malignancies infected with the human T cell lymphoma virus (HTLV), were used in co-culture experiments to infect newborn cord blood lymphocytes (CBL). The infected and non-infected CBL cell lines were typed for HLA alloant
Nature. 1983 Oct 6-12;305(5934):502-5. Unique Identifier : AIDSLINE MED/84014097
Chen IS; McLaughlin J; Gasson JC; Clark SC; Golde DW
A novel human retrovirus (HTLV-II) was previously found associated with a T-cell variant of hairy-cell leukaemia. Molecular cloning demonstrates that the complete provirus genome is 8.8 kilobase pairs in size and is transmissible to uninfected cells. Two types of infectious deleted provirus were also characterized. Th
Nature. 1983 Oct 13-19;305(5935):605-8. Unique Identifier : AIDSLINE MED/84014125
Robbins KC; Antoniades HN; Devare SG; Hunkapiller MW; Aaronson SA
The predicted amino acid sequence of the simian sarcoma virus (SSV) transforming gene product, p28sis, closely corresponds to that of human platelet-derived growth factor (PDGF). We demonstrate that p28sis rapidly undergoes a series of discrete processing steps including dimer formation and proteolytic digestion to yi
Human fibroblast cell lines established from skin biopsies of patients with Wiskott-Aldrich syndrome (WAS), a sex-linked immunodeficiency disorder, were found to have unusually high sensitivity to SV40 infection. When examined by immunofluorescence, two of the cell lines showed almost 100% positive staining for tumor
Retroviruses received widespread attention in the past not only because they caused tumors in animals and, perhaps, in man, but also because they served as useful tools to elucidate molecular mechanisms involved in the control of eukaryotic gene expression. In this brief overview, evidences are presented that retrovir
A short review of the data on retroviruses and human tumors from the past is given and discussed in comparison to some features of animal oncoviruses. The epidemiological association of a newly isolated retrovirus (HTLV/ATLV) with human adult T-cell lymphomas and the demonstration of onc-genes homologous to those of r
Lancet. 1983 Oct 15;2(8355):869-73. Unique Identifier : AIDSLINE MED/84012921
London WT; Sever JL; Madden DL; Henrickson RV; Gravell M; Maul DH; Dalakas MC; Osborn KG; Houff SA; Gardner MB
A disease that is similar to human AIDS may occur in monkeys. Simian AIDS (SAIDS) was experimentally transmitted from 2 rhesus monkeys dying of the disease to 4 cytomegalovirus ( CMV ) antibody-negative rhesus monkeys. The inoc
Lancet. 1983 Oct 15;2(8355):873-8. Unique Identifier : AIDSLINE MED/84012922
Malebranche R; Arnoux E; Guerin JM; Pierre GD; Laroche AC; Pean-Guichard C; Elie R; Morisset PH; Spira T; Mandeville R; et al
29 patients (19 males and 10 females) in Haiti were diagnosed as having acquired immunodeficiency syndrome. Their clinical presentation was characterised by unexplained chronic diarrhoea, prolonged fever, extreme weight loss, anorexia, and severe infections. The infectious agents in
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