Neopterin excretion in urine of patients with AIDS was measured by high pressure liquid chromatography. Urinary neopterin levels in patients with generalized lymphadenopathy, which is considered to be part of the spectrum of AIDS, as well as in severe AIDS cases were significantly elevated, compared to normal controls
The organization of sensory representations in the cortex of the anterior ectosylvian sulcus (AES) of the cat was investigated using single-unit recording techniques. Somatic, auditory, and visual cells were found in the AES but were partially segregated. Somatic cells were concentrated in the rostral two-thirds of th
The acquired immune deficiency syndrome (AIDS) is a recently described T-cell deficiency predisposing patients to a spectrum of opportunistic infections. Kaposi s sarcoma, and other neoplasms. It appears primarily among homosexual males and intravenous drug abusers, but is now being observed in other groups as well. T
A 25-year-old black male homosexual with AIDS presented with Kaposi s sarcoma of the tongue, palate and skin. The definition, epidemiology, diagnosis, treatment and prognosis of AIDS are discussed. The role of the otolaryngologist-head and neck surgeon in diagnosing this disease is outlined.
A 38-year-old male homosexual with the new Acquired Immunodeficiency Syndrome (AIDS) had biopsy proven Kaposi s sarcoma of the right palpebral conjunctiva, extraocular mucocutaneous areas, and lymph nodes. Histologically, the palpebral tumor was characterized by atypical spindle cell proliferation and multiple slit-li
Z Gesamte Inn Med. 1983 Aug 1;38(15):418-21. Unique Identifier : AIDSLINE MED/84047336
Mosonyi L
The immunodeficiency, at present an important complex of research, can be classified in 4 main groups. Primary forms can be separated from secondary ones, a third group of interactional type from a fourth one of compensatory character. We suggest a new classification based on a common point of view, which avoids terms
The acquired immunodeficiency syndrome (AIDS) appears to be expanding both in the population at risk and in its clinical form of presentation. Persistent generalized lymphadenopathy has been reported in homosexual men who have immunologic abnormalities associated with AIDS. We are reporting ten cases of unexplained pe
Cases of acquired immune deficiency syndrome (AIDS) continue to be reported at an alarming rate. As the numbers of cases increase, so too does the list of unusual manifestations associated with this syndrome. We report here a patient with AIDS who, during his clinical course, had a previously undescribed, histological
Coleman DL; Dodek PM; Luce JM; Golden JA; Gold WM; Murray JF
The records of 35 adult male patients with suspected Pneumocystis carinii pneumonia and the acquired immune deficiency syndrome were reviewed to determine the diagnostic utility of fiberoptic bronchoscopy. Twenty-two of the 24 patients (92%) shown to have Pneumocystis pneumonia were diagnosed by bronchoscopy; 20 patie
Ann Intern Med. 1983 Nov;99(5):621-4. Unique Identifier : AIDSLINE MED/84050575
Jett JR; Kuritsky JN; Katzmann JA; Homburger HA
A 53-year-old white man had fever, malaise, and dyspnea on exertion. His chest roentgenogram was normal, but pulmonary function tests showed impaired diffusion capacity and a gallium scan showed marked uptake in the lungs. Results of an open-lung biopsy documented Pneumocystis carinii pneumonia. Immunologic test resul
Weintrub PS; Koerper MA; Addiego JE Jr; Drew WL; Lennette ET; Miner R; Cowan MJ; Ammann AJ
To assess the immunologic status of healthy persons with hemophilia A, we performed studies of T cell immunity in 21 patients, 10 given only cryoprecipitate and 11 given factor VIII concentrate. Patients in the factor VIII group had significantly decreased helper/suppressor T cell ratios. Both groups had diminished mo
The pathogenesis of the acquired immune deficiency syndrome (AIDS) is still unknown. However, it appears to develop in the milieu of prolonged immunodeficiency. Recently, the disease has reached almost epidemic proportions among homosexuals. Patients with AIDS present primarily with disseminated Kaposi s sarcoma and/o
The complete amino acid sequence of human T-cell leukemia virus (HTLV) structural protein p15 has been determined. The intact protein and peptides generated by enzymatic digestion and acid cleavage were purified by reversed-phase liquid chromatography and subjected to semi-automated Edman degradation. HTLV p15 is a ba
Knapp AB; Horst DA; Eliopoulos G; Gramm HF; Gaber LW; Falchuk KR; Falchuk ZM; Trey C
This case report documents extensive gastrointestinal cytomegalovirus infection in a patient with acquired immunodeficiency syndrome, presenting as diarrhea and involving stomach, duodenum, and colon. Endoscopic biopsy specimens and cultures were essential to make the diagnosis and
Gertler SL; Pressman J; Price P; Brozinsky S; Miyai K
A 44-yr-old white homosexual man with a history of Pneumocystis carinii pneumonia developed watery diarrhea and fever. Flexible sigmoidoscopy revealed yellow plaques in the sigmoid colon suggestive of pseudomembranous colitis. Stool examination for ova and parasites, Clostridium difficile toxin, and cultures for patho
Substantial corticotectal (and corticothalamic) projections from the cortex of the anterior ectosylvian sulcus (AES) were demonstrated in the cat using the axonal transport methods of autoradiography and horseradish peroxidase. The corticotectal projection arises nearly exclusively from medium-large pyramidal cells in
Nature. 1983 Oct 20-26;305(5936):733-6. Unique Identifier : AIDSLINE MED/84039776
Lando Z; Sarin P; Megson M; Greene WC; Waldman TA; Gallo RC; Broder S
Certain adult T-cell lymphoproliferative disorders are associated with human T-cell leukaemia virus (HTLV), a unique human type C retrovirus. (The strains of HTLV used in these studies belong to the subgroup HTLV-I.) HTLV is not an endogenous agent in man, but rather is an acquired virus with T-cell tropism. Neoplasti
Holland GN; Pepose JS; Pettit TH; Gottlieb MS; Yee RD; Foos RY
The acquired immune deficiency syndrome (AIDS) is a recently described disorder of cellular immunity in homosexuals, intravenous drug abusers, and Haitians. Manifestations include Kaposi s sarcoma, Pneumocystis carinii pneumonia, and other opportunistic infections. Ophthalmic and autopsy examinations of 30 patients at
Rosenberg PR; Uliss AE; Friedland GH; Harris CA; Small CB; Klein RS
Twenty-five ambulatory patients with acquired immunodeficiency syndrome (AIDS) were studied over a 6-month period. Fourteen (56%) of the patients were heterosexuals with a history of intravenous drug abuse. Ocular involvement was seen in 40% of patients, cotton-wool spots being the major manifestation. Findings consis
Thromb Haemost. 1983 Aug 30;50(2):552-6. Unique Identifier : AIDSLINE MED/84045560
Lechner K; Niessner H; Bettelheim P; Deutsch E; Fasching I; Fuhrmann M; Hinterberger W; Korninger C; Neumann E; Liszka K; et al
Various immunological parameters were determined in 46 patients with severe hemophilia A and in 9 patients with severe hemophilia B. All patients were treated over many years with commercial factor VIII or IX concentrates. Patients with severe classic hemophilia had a significantly reduced relative and absolute number
Possibility of rapid generation of highly transforming viruses from rabbit epithelial corneal cells (Sirc) on the basis of SSAV virus is discussed. The results of the study suggested a relationship between the phenomenon of phenotypic transformation with expression of cellular genes and a potential transforming activi
A 38-year-old black man died from acquired immunodeficiency syndrome (AIDS) after a 15-month course. The autopsy revealed a pancolitis and a pneumonia caused by cytomegalovirus ( CMV ). Exceptionally, there also was a periventr
Frank JA Jr; Warren RW; Tucker JA; Zeller J; Wilfert CM
An 8-month-old male infant with severe combined immunodeficiency syndrome was admitted to the hospital with pneumonitis and, subsequently, died at 21 months of age. During his lengthy hospitalization, parainfluenza virus type 3 (PIV-3) was isolated from respiratory secretions and unusual sites, such as pericardial flu
Fifty patients with acquired immune deficiency syndrome had complications affecting the central or peripheral nervous systems or both. The patients were either male homosexuals, intravenous drug abusers, or recently arrived Haitian refugees. They ranged in age from 25 to 56. Central nervous system complications were o
Analysis of the data from the literature and reports of epidemic outbreaks of Kaposi sarcoma in a number of countries suggest at present that this tumor is etiologically and pathogenetically associated with cell-mediated immunity deficiency and cytomegalovirus infection.
Lancet. 1983 Nov 12;2(8359):1109-11. Unique Identifier : AIDSLINE MED/84038536
Jaffe HS; Abrams DI; Ammann AJ; Lewis BJ; Golden JA
In 8 of 18 homosexual men with the acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii pneumonia (PCP) treated with intravenous co-trimoxazole (trimethoprim-sulphamethoxazole) apparent drug-related complications developed during the course of acute therapy. A symptom complex of fevers and increasing mal
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