Acquired immune deficiency syndrome (AIDS). Light microscopic, ultrastructural and immunocytochemical studies of one case. NLM AIDSLINE Important note: Information in this article was accurate in 1984. The state of the art may have changed since the publication date.

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Acquired immune deficiency syndrome (AIDS). Light microscopic, ultrastructural and immunocytochemical studies of one case.

J Submicrosc Cytol. 1984 Jul;16(3):561-8. Unique Identifier : AIDSLINE MED/84292402
Allegra SR; Chao T; Pella JA

Abstract: The lung and axillary lymph node biopsies of a 33-year-old male drug-abuser with clinical and immunologic evidences of AIDS were studied by light and electron microscopy. Encysted Pneumocystis carinii organisms with attached membranous expansions and virus-like particles were demonstrated in the alveolar spaces and, occasionally, in macrophages. The lymph node biopsy revealed areas of angioimmunoblastic proliferation associated with lymphocytic depletion of the interfollicular zones. Tubuloreticular structures (TRS) were prominent in lymphocytes and endothelial cells. Test-tube and ring-shaped forms (TRF) were less frequently seen and were present only in lymphocytes and immunoblasts. The combination of TRS and TRF appears to be an useful marker for AIDS. The possible significance of the angioimmunoblastic changes observed in the lymph nodes is also discussed.
Keywords: Acquired Immunodeficiency Syndrome/*PATHOLOGY Adult Biopsy Case Report Human Lung/PATHOLOGY/*ULTRASTRUCTURE Lymph Nodes/PATHOLOGY/*ULTRASTRUCTURE Male Microscopy, Electron Phagocytosis Pneumocystis carinii/ISOLATION & PURIF/ULTRASTRUCTURE Substance Abuse/COMPLICATIONS JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDpathologyadultbiopsycasereporthumanlung/pathology/KWDultrastructurelymphnodes/pathology/KWDultrastructuremalemicroscopy,electronphagocytosispneumocystiscarinii/isolation&purif/ultrastructuresubstanceabuse/complicationsjournalarticle
841230
M84C0066

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